Navigation Links
Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics,Publication

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 18, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced today that a new report published in the medical journal, Nature Genetics (Tong et al. Nature Genetics 39:476-485, 2007), showed that Aeolus Pharmaceuticals' lead compound AEOL 10150 (MnTDEIP) can improve survival in fruit flies genetically lacking the neurofibromatosis-1 (NF1) gene. These mutant flies had reduced mitochondrial function and increased production of reactive oxygen species that was associated with a greatly shortened lifespan. Dr. Douglas Wallace's team at the University of California-Irvine concluded that the increased mitochondrial Reactive Oxygen Species (ROS) production resulting from NF1 mutations could be an important factor in the generation of neurofibromas. If so, then the suppression of mitochondrial ROS production through the treatment with catalytic antioxidants such as AEOL 10150 may provide a powerful new approach to treat NF1, as well as other cancers.

Many common neurodegenerative diseases including Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and Alzheimer's disease are often associated with mitochondrial dysfunction and the overproduction of reactive oxygen species. Neurofibromatosis is a common neurogenetic disorder that afflicts 1 in 3,000 people worldwide. Humans that harbor mutant neurofibromatous-1 genes are at increased risk of developing cancer and often have learning disabilities and developmental abnormalities.

AEOL 10150 has been shown to be safe and well-tolerated in both a single and a multi-dose phase 1 studies. In animal models, the compound has shown promise in ALS, protection of healthy cells from radiation therapy, Parkinson's disease, stroke and neurofibromatosis, among other indications. The Company is currently in the process of planning and securing the financial resources to support a phase 2 study to test the efficacy of AEOL 10150
'"/>




Page: 1 2 3

Related medicine technology :

1. Study Demonstrating Aeolus Compounds Neuroprotection in Parkinsons Disease Published in the Journal of Neuroscience
2. Aeolus Pharmaceuticals AEOL 10113 May Play an Important Role Regulating the Oxidative Damage Induced by Ionizing Radiation
3. Aeolus Pharmaceuticals AEOL 10113 Demonstrates Potential as a Protector of Healthy Normal Cells from Cancer Radiation Therapy
4. Aeolus Pharmaceuticals Announces Successful Completion of Multiple Dose Safety Study of AEOL 10150
5. Faust Pharmaceuticals Phase IIa Results for Parkinsons Disease Presented at International Congress of Parkinsons Disease and Movement Disorders
6. Data from Rexahn Pharmaceuticals Phase I Trial of RX-0201 (Archexin) to Be Presented at the 43rd American Society of Clinical Oncology Annual Meeting in Chicago
7. VGX Pharmaceuticals Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models
8. ACADIA Pharmaceuticals Schizophrenia Programs to Be Presented at the 2007 International Congress on Schizophrenia Research
9. Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology
10. Isotechnikas Lead Drug, ISA247, To Be Highlighted at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
11. Gentiums Defibrotide Highlighted in Poster Presentation at World Congress of Nephrology
Post Your Comments:
(Date:8/1/2014)... 1, 2014 Research and Markets ... "Global Medical Biosensors Market 2014-2018" report to ... Medical biosensors are used to ... detectors. These biosensors monitor health status, disease betterment, ... methods. They are cost-effective and user-friendly devices. Also, ...
(Date:8/1/2014)... 1, 2014  NxStage Medical, Inc. (Nasdaq: NXTM ... that Jeffrey H. Burbank , Chief Executive Officer, and ... the 34 th Annual Canaccord Genuity Growth Conference being ... , on Wednesday, August 13 th at 4:30 p.m. ... at http://ir.nxstage.com/ .  About NxStage Medical ...
(Date:8/1/2014)... 2014 Dyadic International, Inc. ("Dyadic") (OTCQX: DYAI), ... are used to develop, manufacture and sell enzymes and ... industrial enzyme industries, announced today that it will report ... 30, 2014 after market close on Thursday, August 14, ... at 5:00 p.m. Eastern Time to discuss those results. ...
Breaking Medicine Technology:Global Medical Biosensors Market 2014-2018: Key Vendors are Abbott, Bayer, LifeScan and F. Hoffmann-La Roche 2NxStage to Present at the 34th Annual Canaccord Genuity Growth Conference 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3
... Alere Inc. (NYSE: ALR ) ("Alere") announced ... totaling $2.1 billion.  Jefferies Finance LLC, GE Capital Markets, ... as joint lead arrangers for the credit facilities, and ... for the lenders under the credit facilities. ...
... Qmed.com , a UBM Canon publishing group brand ... directory and search engine, announced its supplier profiles are ... websites. This new search functionality allows medical device professionals ... paid listings) in search results when they conduct keyword ...
Cached Medicine Technology:Alere Inc. Announces $2.1 Billion Credit Facilities 2Qmed Profiles Searchable Across All Medical Device Websites 2Qmed Profiles Searchable Across All Medical Device Websites 3
(Date:8/1/2014)... Cannabis use among young people has spiked, ... 17 having used marijuana at least once and 17 percent ... ‘No’ to Drugs, Say ‘Yes to Life,’ volunteers from the ... this summer with factual information about drugs, to help reverse ... “Say ‘No’ to Drugs, Say ‘Yes’ to Life,” volunteers have ...
(Date:8/1/2014)... in regulating appetite and whole-body metabolism. A protein known ... food intake and body weight, but the identity of ... A new study in the Journal of ... type of neuron known as pro-opiomelanocortin (POMC) neurons is ... Sabrina Diano and colleagues at Yale University School of ...
(Date:8/1/2014)... 1, 2014 (HealthDay News) -- The U.S. Food and ... new drug, Jardiance, to help fight type 2 diabetes. ... added to existing treatment regimens to control blood sugar ... Rosebraugh, director of the Office of Drug Evaluation II ... said in an agency statement. The FDA also ...
(Date:8/1/2014)... Summer is here, and with it comes ... summer, and they can be a pain for dogs. Animal ... all their customers get rid of ticks and prevent them ... in the summer, which is why they are so active ... and woodland areas and carry a number of diseases, including ...
(Date:8/1/2014)... and the benefits of a cancer diagnosis may improve ... a study conducted by a researcher at the University ... an expressive writing intervention is the writing instruction. Otherwise, ... events. Writing a journal can be therapeutic, but oftentimes ... it,s effective or not," said Qian Lu, assistant professor ...
Breaking Medicine News(10 mins):Health News:Addressing a Serious Issue Affecting German Teens 2Health News:FDA Approves New Type 2 Diabetes Drug 2Health News:Tis the Season for Tick Prevention 2Health News:Expressive writing may help breast cancer survivors 2Health News:Expressive writing may help breast cancer survivors 3
... in rates between 2005 and 2007 , , THURSDAY, April 16 ... a hazard for U.S. workers, a new government report shows. ... employed adults declined overall between 1994 and 2007, there was ... to a report in the April 17 issue of ...
... cause and effect , , THURSDAY, April 16 (HealthDay News) ... A and C in their diet may be at increased ... of 40 studies conducted between 1980 and 2007 showed that ... vitamin A than those without the disease. The average intake ...
... Va., April 16 An African child dies every ... billion people become ill because of it. About 1 ... year from malaria -- a disease that is entirely ... Fund Senior Program Health Specialist David Shanklin stresses the ...
... Community Measurement issues second annual report on health care ... nationMINNEAPOLIS, April 16 Although the care provided to ... improved since the last report on eight of nine ... quality of care provided to patients on public health ...
... the infection, CDC warns, , , THURSDAY, April 16 (HealthDay ... that while rates of testing for sexually transmitted ... of young, sexually active U.S. women still do not ... Disease Control and Prevention combed through 2000-07 data reported ...
... has found that a painful pelvic affliction associated with ... prostatitis or chronic pelvic pain syndrome (CP/CPPS) is a ... genital pain. , This is the first study ... males, and to show the negative impact that pain, ...
Cached Medicine News:Health News:Lead Exposure in Workplace Still a Problem 2Health News:Low Vitamin A, C Intake Tied to Asthma Risk 2Health News:Every 30 Seconds an African Child Dies from Malaria; Education Key to Prevention 2Health News:Every 30 Seconds an African Child Dies from Malaria; Education Key to Prevention 3Health News:Several Minnesota Medical Groups Improve Care for Patients Served by Minnesota Health Care Programs, but Disparities Gap Remains 2Health News:Several Minnesota Medical Groups Improve Care for Patients Served by Minnesota Health Care Programs, but Disparities Gap Remains 3Health News:Less Than Half of Young Women Screened for Chlamydia 2Health News:Pelvic pain as prevalent in teens as older males, Queen's researchers discover 2
Femoral selective diagnostic catheter. The material used is nylon (VESTANTM). All selective shapes have thrulumen design. Guidewire campatibility is 0.038". Packaging 5/Box....
... a complete offering of cardiology catheters. Available ... catheters are designed with excellent torque, new ... better push-ability, and large inner lumens for ... 6 and 7 French sizes with pressure ...
The Compass Commander series is engineered to provide the discriminating neurosurgeon with the same capabilities offered within the commander plus+, all in a smaller, lower-cost package....
Used for access and catheterization procedures. Double flexible tipped design permits alternative use of both ends of wire guide depending upon procedural needs. Supplied sterile in peel-open package...
Medicine Products: