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Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics,Publication

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 18, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced today that a new report published in the medical journal, Nature Genetics (Tong et al. Nature Genetics 39:476-485, 2007), showed that Aeolus Pharmaceuticals' lead compound AEOL 10150 (MnTDEIP) can improve survival in fruit flies genetically lacking the neurofibromatosis-1 (NF1) gene. These mutant flies had reduced mitochondrial function and increased production of reactive oxygen species that was associated with a greatly shortened lifespan. Dr. Douglas Wallace's team at the University of California-Irvine concluded that the increased mitochondrial Reactive Oxygen Species (ROS) production resulting from NF1 mutations could be an important factor in the generation of neurofibromas. If so, then the suppression of mitochondrial ROS production through the treatment with catalytic antioxidants such as AEOL 10150 may provide a powerful new approach to treat NF1, as well as other cancers.

Many common neurodegenerative diseases including Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and Alzheimer's disease are often associated with mitochondrial dysfunction and the overproduction of reactive oxygen species. Neurofibromatosis is a common neurogenetic disorder that afflicts 1 in 3,000 people worldwide. Humans that harbor mutant neurofibromatous-1 genes are at increased risk of developing cancer and often have learning disabilities and developmental abnormalities.

AEOL 10150 has been shown to be safe and well-tolerated in both a single and a multi-dose phase 1 studies. In animal models, the compound has shown promise in ALS, protection of healthy cells from radiation therapy, Parkinson's disease, stroke and neurofibromatosis, among other indications. The Company is currently in the process of planning and securing the financial resources to support a phase 2 study to test the efficacy of AEOL 10150
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