Navigation Links
Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics,Publication

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 18, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced today that a new report published in the medical journal, Nature Genetics (Tong et al. Nature Genetics 39:476-485, 2007), showed that Aeolus Pharmaceuticals' lead compound AEOL 10150 (MnTDEIP) can improve survival in fruit flies genetically lacking the neurofibromatosis-1 (NF1) gene. These mutant flies had reduced mitochondrial function and increased production of reactive oxygen species that was associated with a greatly shortened lifespan. Dr. Douglas Wallace's team at the University of California-Irvine concluded that the increased mitochondrial Reactive Oxygen Species (ROS) production resulting from NF1 mutations could be an important factor in the generation of neurofibromas. If so, then the suppression of mitochondrial ROS production through the treatment with catalytic antioxidants such as AEOL 10150 may provide a powerful new approach to treat NF1, as well as other cancers.

Many common neurodegenerative diseases including Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and Alzheimer's disease are often associated with mitochondrial dysfunction and the overproduction of reactive oxygen species. Neurofibromatosis is a common neurogenetic disorder that afflicts 1 in 3,000 people worldwide. Humans that harbor mutant neurofibromatous-1 genes are at increased risk of developing cancer and often have learning disabilities and developmental abnormalities.

AEOL 10150 has been shown to be safe and well-tolerated in both a single and a multi-dose phase 1 studies. In animal models, the compound has shown promise in ALS, protection of healthy cells from radiation therapy, Parkinson's disease, stroke and neurofibromatosis, among other indications. The Company is currently in the process of planning and securing the financial resources to support a phase 2 study to test the efficacy of AEOL 10150
'"/>




Page: 1 2 3

Related medicine technology :

1. Study Demonstrating Aeolus Compounds Neuroprotection in Parkinsons Disease Published in the Journal of Neuroscience
2. Aeolus Pharmaceuticals AEOL 10113 May Play an Important Role Regulating the Oxidative Damage Induced by Ionizing Radiation
3. Aeolus Pharmaceuticals AEOL 10113 Demonstrates Potential as a Protector of Healthy Normal Cells from Cancer Radiation Therapy
4. Aeolus Pharmaceuticals Announces Successful Completion of Multiple Dose Safety Study of AEOL 10150
5. Faust Pharmaceuticals Phase IIa Results for Parkinsons Disease Presented at International Congress of Parkinsons Disease and Movement Disorders
6. Data from Rexahn Pharmaceuticals Phase I Trial of RX-0201 (Archexin) to Be Presented at the 43rd American Society of Clinical Oncology Annual Meeting in Chicago
7. VGX Pharmaceuticals Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models
8. ACADIA Pharmaceuticals Schizophrenia Programs to Be Presented at the 2007 International Congress on Schizophrenia Research
9. Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology
10. Isotechnikas Lead Drug, ISA247, To Be Highlighted at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
11. Gentiums Defibrotide Highlighted in Poster Presentation at World Congress of Nephrology
Post Your Comments:
(Date:4/21/2015)... -- A groundbreaking new, minimally invasive outpatient treatment option ... is now readily available to the estimated 1 million ... who suffer from this condition. ... leading practitioner of this safe, effective, Federal Drug Administration-approved ... new Los Angeles -area medical centers ...
(Date:4/21/2015)... 2015 Oxfordshire ... more than doubled its overseas sales in just 4 ... winning the Queen,s Award for Enterprise, for Outstanding Achievement ... first HealthScience Communications consultancy, helping its clients bring new ... Having more than doubled its exports in just 4 ...
(Date:4/21/2015)... Cardiologists at Henry Ford Hospital have implanted a ... an irregular heartbeat. With only handful of hospitals ... is able to add another option to its arsenal of ... heart,s ability to pump. "This is a ... Watchman implant at a non-clinical trial site," says cardiologist ...
Breaking Medicine Technology:New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 2New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 3New Minimally Invasive Treatment for Uterine Fibroids Offers Life-Changing Relief, Without a Hysterectomy, to 1 Million Southern California Women 4Queen's Award Crowns Achievements of Local Consultancy 2Queen's Award Crowns Achievements of Local Consultancy 3Queen's Award Crowns Achievements of Local Consultancy 4Queen's Award Crowns Achievements of Local Consultancy 5Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 2Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 3
(Date:4/21/2015)... 2015 My Patriot Supply is proud ... latest innovation in home water filtration: Alexapure Pro™ ... that makes existing gravity-fed filters obsolete. An unprecedented advancement ... industry standards for water filtration. With an optimized flow ... typical household. , The Alexapure Pro™ takes a unique, ...
(Date:4/21/2015)... Sinking Spring, PA (PRWEB) April 21, 2015 ... neighboring Berks County commercial printer, Offset Impressions. ... with its full line of printing capabilities and knowledgeable ... Grafika. “This acquisition allows us to offer an ... addition to the labeling, packaging, and specialty services we ...
(Date:4/21/2015)... The California Healthcare Institute (CHI), ... sciences organizations, released the following statement by CHI ... Assembly Bill (AB) 463: , “As innovators in ... of treatments and cures for patients with serious ... AB 463, the so-called Pharmaceutical Cost Transparency Act ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Information is the ... Kevin Ryan, MD, FACP, empowers patients and their families with ... is the Rumor and Cancer is the Answer" and ... and informative language to guide patients from diagnosis through treatment ... patients active participants in their treatment, at home and in ...
(Date:4/21/2015)... 2015 The report “Dermatitis ... analysis on the therapeutic development for Dermatitis. ... identifying new targets and MOAs to produce ... TOC is available @ http://www.rnrmarketresearch.com/dermatitis-pipeline-review-h1-2015-market-report.html ... players involved in the therapeutic development for ...
Breaking Medicine News(10 mins):Health News:Preparedness Leader My Patriot Supply Unveils the New Alexapure Pro™ Water Filter 2Health News:California Healthcare Institute Statement on AB 463 2Health News:California Healthcare Institute Statement on AB 463 3Health News:Authoritative guide and new accompanying therapeutic web portal bridge information gaps in cancer treatment 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 4
... Sept. 30 Heartland Information Services, a national provider ... Himes to President and Chief Executive Officer. Previously Chief ... the President and CEO position immediately. , Himes will ... who has accepted a new position with Reichert, Inc. ...
... NEW YORK (Sept. 30, 2009) -- New research by ... ways parents and peers influence teenagers to smoke, drink ... toward smoking influenced teenagers, use of multiple drugs (smoking, ... in boys and girls. For girls, friends were ...
... system made of billions of neurons and thousands of ... of the strongest emotions, fear. Most neurological fear studies ... Missouri researchers have started using computational models of the ... Guoshi Li, an electrical and computer engineering doctoral student, ...
... a third of U.S. victims were also infected with pneumococcus ... News) -- Bacterial co-infections are common among people who have ... probably contributed to their deaths, according to a new federal ... Control and Prevention analyzed lung tissue samples from 77 people ...
... U.S. Food and Drug Administration today announced the availability ... Evaluation and Mitigation Strategies or REMS, which are required ... http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ) , The Food and Drug ... the authority to require the submission and implementation of ...
... ARLINGTON, Va. and BOSTON, Sept. 30 On November 16, ... GO! and Boston creative group CloudKid, invite early elementary school ... and friends in FIZZY,S LUNCH LAB ( PBSKIDSGO.org/lunchlab ... good and bad food, and learn what happens once the ...
Cached Medicine News:Health News:Heartland Information Services Appoints New Chief Executive Officer 2Health News:Teen attitudes toward smoking linked to likelihood of drinking and using drugs 2Health News:Researchers use computational models to study fear 2Health News:CDC Links Infections With Swine Flu Deaths 2Health News:CDC Links Infections With Swine Flu Deaths 3Health News:FDA Issues Draft Guidance on Risk Evaluation and Mitigation Strategies 2Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 2Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 3Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 4Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 5Health News:Video: Laughter is the Key Ingredient in 'FIZZY'S LUNCH LAB,' a New Health-Themed Web-Only Property Launching November 16 on PBSKIDSGO.org 6
... has been approved for use as an ... seizures in adults and adolescents over 12 ... that are refractory to antiepileptic medications. This ... controlled, clinical trials. Efficacy, measured as median ...
... Electrodes share similar characteristics with ... difference is that all of ... to assist you intraoperatively. In ... for use with either our ...
State-of-the-art sleep recording and analysis...
... workstation is a medical device designed to ... video capability, and archiving demands of the ... A framework that helps organize workflow and ... A centralized database and powerful search capability ...
Medicine Products: