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Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics,Publication

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 18, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced today that a new report published in the medical journal, Nature Genetics (Tong et al. Nature Genetics 39:476-485, 2007), showed that Aeolus Pharmaceuticals' lead compound AEOL 10150 (MnTDEIP) can improve survival in fruit flies genetically lacking the neurofibromatosis-1 (NF1) gene. These mutant flies had reduced mitochondrial function and increased production of reactive oxygen species that was associated with a greatly shortened lifespan. Dr. Douglas Wallace's team at the University of California-Irvine concluded that the increased mitochondrial Reactive Oxygen Species (ROS) production resulting from NF1 mutations could be an important factor in the generation of neurofibromas. If so, then the suppression of mitochondrial ROS production through the treatment with catalytic antioxidants such as AEOL 10150 may provide a powerful new approach to treat NF1, as well as other cancers.

Many common neurodegenerative diseases including Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and Alzheimer's disease are often associated with mitochondrial dysfunction and the overproduction of reactive oxygen species. Neurofibromatosis is a common neurogenetic disorder that afflicts 1 in 3,000 people worldwide. Humans that harbor mutant neurofibromatous-1 genes are at increased risk of developing cancer and often have learning disabilities and developmental abnormalities.

AEOL 10150 has been shown to be safe and well-tolerated in both a single and a multi-dose phase 1 studies. In animal models, the compound has shown promise in ALS, protection of healthy cells from radiation therapy, Parkinson's disease, stroke and neurofibromatosis, among other indications. The Company is currently in the process of planning and securing the financial resources to support a phase 2 study to test the efficacy of AEOL 10150 in humans.

About Aeolus Pharmaceuticals

Aeolus is developing a variety of therapeutic agents based on its proprietary small molecule catalytic antioxidants, with AEOL 10150 being the first to enter human clinical evaluation. AEOL 10150 is a patented, small molecule catalytic antioxidant that has shown the ability to scavenge a broad range of reactive oxygen species, or free radicals. As a catalytic antioxidant, AEOL 10150 mimics and thereby amplifies the body's natural enzymatic systems for eliminating these damaging compounds. Because oxygen-derived free radicals are believed to have an important role in the pathogenesis of many diseases, Aeolus' catalytic antioxidants are believed to have a broad range of potential therapeutic uses.

The statements in this press release that are not purely statements of historical fact are forward-looking statements. Such statements include, but are not limited to, those relating to Aeolus' product candidates, as well as its proprietary technologies and research programs. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause Aeolus' actual results to be materially different from historical results or from any results expressed or implied by such forward-looking statements. Important factors that could cause results to differ include risks associated with uncertainties of progress and timing of clinical trials, scientific research and product development activities, difficulties or delays in development, testing, obtaining regulatory approval, the need to obtain funding for pre-clinical and clinical trials and operations, the scope and validity of intellectual property protection for Aeolus' product candidates, proprietary technologies and their uses, and competition from other biopharmaceutical companies. Certain of these factors and others are more fully described in Aeolus' filings with the Securities and Exchange Commission, including, but not limite d to, Aeolus' Quarterly Report on Form 10-Q for the quarter ended December 31, 2006. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof.


Aeolus Pharmaceuticals, Inc.
John L. McManus, President and Chief Executive Officer


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