Navigation Links
Aeolus Pharmaceuticals' AEOL 10113 May Play an Important Role,Regulating the Oxidative Damage Induced by Ionizing Radiation

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 23, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced the presentation of data by researchers at Loma Linda University Medical Center showing that one of the Company's metalloporphyrin antioxidants, AEOL 10113, may play an important role regulating the oxidative damage induced by ionizing radiation.

Radiation therapy is used alone or in combination with surgery and chemotherapy in the care and management of nearly all adult and approximately 75% of pediatric patients with central nervous system malignancies. Success in controlling a brain cancer by radiation therapy hinges on being able to inactivate the cancer cells while preserving normal tissue function.

This study evaluated retinal endothelial cell response to radiation in the presence of a metalloporphyrin antioxidant, AEOL 10113, using monkey choroid-retina endothelial cells. AEOL 10113 was added to the cells one hour prior to the administration of a single, 10 grey dose of radiation. Statistically significant (P less than 0.05), dose-dependent protection of normal retinal endothelial cells by AEOL 10113 was seen at 24 hours and 48 hours following irradiation. In addition, cell viability was significantly enhanced at 24 hours and 48 hours in non-irradiated endothelial cells cultured with AEOL 10113 at 10ug (P less than 0.05). Laser scanning cytometry showed AEOL 10113 altered cell cycle kinetics and led to significantly (p less than 0.05) increased G1 population 48 hours following irradiation.

The Potential for Metalloporphyrin Antioxidants in Radiotherapy for Cancer

Radiotherapy treatment in cancer has the positive effect of tumor destruction, but also has the negative effect of normal tissue damage. Optimal dosing in radiotherapy balances maximum tumor destruction with minimal toxicity and damage to normal tissue. The "ionizing radiation" used in cancer radiotherapy generates reac
'"/>




Page: 1 2 3

Related medicine technology :

1. Study Demonstrating Aeolus Compounds Neuroprotection in Parkinsons Disease Published in the Journal of Neuroscience
2. Aeolus Pharmaceuticals AEOL 10113 Demonstrates Potential as a Protector of Healthy Normal Cells from Cancer Radiation Therapy
3. Aeolus Pharmaceuticals AEOL 10150 Highlighted in Nature Genetics Publication
4. Aeolus Pharmaceuticals Announces Successful Completion of Multiple Dose Safety Study of AEOL 10150
5. Faust Pharmaceuticals Phase IIa Results for Parkinsons Disease Presented at International Congress of Parkinsons Disease and Movement Disorders
6. Data from Rexahn Pharmaceuticals Phase I Trial of RX-0201 (Archexin) to Be Presented at the 43rd American Society of Clinical Oncology Annual Meeting in Chicago
7. VGX Pharmaceuticals Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models
8. ACADIA Pharmaceuticals Schizophrenia Programs to Be Presented at the 2007 International Congress on Schizophrenia Research
9. New Report Looking at Chiral Technologies Analyzes the Global Market Growth Forecasts Driven By Two Very Important Components as Single Isomer Drugs and Single Enantiomer Pharmaceuticals
10. Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur
11. Landmark Study Published in the New England Journal of Medicine Shows Important Benefits of Eprodisate (KIACTA) Treatment for Patients with Amyloid A (AA) Amyloidosis
Post Your Comments:
(Date:1/22/2015)... Corporation (NASDAQ: TECH ) announced today that ... new Simple Plex platform through its Proteins Platform division ... of the previously acquired CyPlex instrument platform from CyVek. ... immunoassay technology which integrates an innovatively designed microfluidic cartridge ...
(Date:1/22/2015)... PARK, Calif. , Jan. 22, 2015 Increasing ... the continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research ... chose a single-source solution for their translation and localization ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Microbiology Testing/Clinical Microbiology Market ... Global Forecast to 2019" report to their ... wide array of techniques for the detection of ...
Breaking Medicine Technology:Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... Corporation (Nasdaq: DRRX ) today reported that King ... Inc. (Nasdaq: PTIE ) have announced that King ... the U.S. Food and Drug Administration (FDA) in response to ... 2008.  This is a Class 2 resubmission with a six ...
... During ICMS (International Cellular Medicine Society www.cellmedicinesociety.org ) ... Conference held on November 12, 2010 in Las Vegas, ... of diabetes gangrene recovered from foot ulcer through stem ... ) Patient, Sun Rae Cho (age 72 ...
Cached Medicine Technology:REMOXY® New Drug Application Resubmitted 2REMOXY® New Drug Application Resubmitted 3New Hope for Saving Diabetic Foot from Amputation 2
(Date:1/22/2015)... PA (PRWEB) January 22, 2015 Woodloch Pines, ... Mountains, has been selected by TripAdvisor as the number one ... the 6th best in the world for their annual Travelers’ ... online travel community . The website is home to millions ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... 22, 2015 Joan Lunden, award-winning American ... at the upcoming 32nd Annual Miami Breast Cancer ... Education Resource®, LLC (PER®) , shares that “a fast-growing, ... undetected if she had not followed up her clean ...
(Date:1/22/2015)... 2015 Four years since the release of their ... with the marriage of Avasa & Matthew Love – the duo ... scheduled for release through White Swan Records on February 24, 2015. ... a sacred path available to all of us to walk out ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... Feb. 21 AK Steel (NYSE:,AKS) said today that ... agreement between AK Steel and a group of retirees ... from the company,s,initiatives in 2006 to reduce its health ... settlement agreement, which established a Voluntary Employees,Beneficiary Association (VEBA) ...
... Feb. 21 The needs of,pregnant women, babies and toddlers ... Healthy Start of Southwest Florida has received a $6,000,grant from ... how we,can best help the 18,000 clients we serve each ... in the last five,years. The population has increased and the ...
... new electron microscope recently installed in Cornell,s Duffield Hall ... images that uniquely identify individual atoms in a crystal ... And in living color. , "The current generation of ... and white cameras where different atoms appear as different ...
... whose discoveries have led to fundamental advances in the ... two prestigious international prizes offered by the Kirk A. ... for Cancer Research (AACR). , The Kirk A. ... Landon-AACR Prize for Translational Cancer Research are among the ...
... Sons, Inc. (NYSE: JWa), (NYSE: JWb), today announced that it ... its worldwide operations that were formerly part of Blackwell Publishing, ... addition to offsetting the carbon footprint of 10 offices around ... that result from the global product shipments from this part ...
... of adverse side effects , , THURSDAY, Feb. ... one nonsteroidal anti-inflammatory drug (NSAID) may have poorer health-related ... which are available in both prescription and over-the-counter (OTC) ... drugs are widely available, and patients may take both ...
Cached Medicine News:Health News:U.S. Court Approves AK Steel's VEBA Health Care Settlement With Middletown Works Retirees 2Health News:Healthy Start of Southwest Florida Receives Grant From March of Dimes to Assess Needs of Pregnant Women and Babies 2Health News:By color-coding atoms, new Cornell electron microscope promises big advance in materials analysis 2Health News:By color-coding atoms, new Cornell electron microscope promises big advance in materials analysis 3Health News:AACR's Seventh Annual Landon Awards 2Health News:AACR's Seventh Annual Landon Awards 3Health News:AACR's Seventh Annual Landon Awards 4Health News:AACR's Seventh Annual Landon Awards 5Health News:Taking Multiple Pain Relievers May Cause Complications 2
Blunt cannula for injection or aspiration of fluid. Thinwall cannula allows high flow rate. Blunt tip is smooth all around for easy insertion. Luer lock hub for easy, secure connection to a backflus...
PLX30s, 30 Watt Sealed CO2 Laser System....
... Pulse sealed CO2 surgical lasers offer unmatched ... experience and support services of a company ... experience. All settings are available at the ... Super Pulse surgical lasers are compatible with ...
Ophthalmic Nd Yag Laser with excellent quality optics for clear image and good laser delivery. Compact and light-weight for portability....
Medicine Products: