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Aeolus Pharmaceuticals' AEOL 10113 Demonstrates Potential as a,Protector of Healthy Normal Cells from Cancer Radiation Therapy

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 19, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced the presentation of data by researchers at Loma Linda University Medical Center, National Jewish Medical and Research Center and Duke University showing that one of the Company's metalloporphyrin antioxidants, AEOL 10113, demonstrated protection of healthy normal cells in mice with prostate tumor cells treated with radiation therapy. The study also showed that the compound did not interfere with the tumor destruction effects of the radiation therapy.

Researchers reported a statistically significant decrease in tumor growth in animals that received radiation alone (p less than 0.05, days 9, 11-14); and in animals that received radiation plus drug (p less than 0.05, days 11-15). Survival was improved in the radiation plus drug group as 15% of the mice survived (with tumor volumes of less than 2,000 cubic mm) 7 and 9 days longer compared to radiation only and drug only groups, respectively. The researchers concluded that the results demonstrate that AEOL 10113 did not protect tumor response to radiation and there were no drug-related toxicities detected. The data support further investigation of metalloporphyrin antioxidants as a normal tissue protectant during radiotherapy.

The Potential for Metalloporphyrin Antioxidants in Radiotherapy for Cancer

Radiotherapy treatment in cancer has the positive effect of tumor destruction, but also has the negative effect of normal tissue damage. Optimal dosing in radiotherapy balances maximum tumor destruction with minimal toxicity and damage to normal tissue. The "ionizing radiation" used in cancer radiotherapy generates reactive oxygen species (ROS) and other free radicals. These free radicals cause DNA damage and cell death. Catalytic antioxidants, such as Aeolus' AEOL 10150 and AEOL 10113 have been shown to neutralize free radicals and can reduce radiati
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