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Advanced Life Sciences Announces Supplemental Efficacy Data from,First Pivotal Phase 3 Pneumonia Clinical Trial

dosing for Biaxin(R), both over a seven-day course of therapy. The clinical cure rates in the modified intent to treat population and the per protocol population observed in this trial with cethromycin were in line with cethromycin phase 2 results and with clinical cure rates observed with currently marketed antibiotics.

"We are pleased with the positive supplemental results achieved in our other endpoints in Trial CL-06," said Dr. Michael T. Flavin, chief executive officer. "This successful trial will be a key part of our NDA submission."

As reported in the Company's June 21 press release, cethromycin demonstrated an improved safety profile when compared with the results seen in its previous clinical trials. Additionally, the incidence of adverse events was not statistically different between cethromycin and Biaxin(R). The most common adverse events reported in patients receiving cethromycin were mild-to-moderate diarrhea (cethromycin 5.0%, Biaxin(R) 4.6%), headache (cethromycin 3.1%, Biaxin(R) 6.5%), nausea (cethromycin 2.7%, Biaxin(R) 3.8%), vomiting (cethromycin 2.7%, Biaxin(R) 1.5%), abdominal pain (cethromycin 1.5%, Biaxin(R) 3.1%) and taste disturbance (cethromycin 11.1%, Biaxin(R) 6.2%). No drug-related serious adverse events were observed in any study subject. Liver function tests and electrocardiogram monitoring demonstrated no significant differences between subjects receiving cethromycin and subjects receiving Biaxin(R), consistent with the hepatic and cardiac side effect profile reported in cethromycin's previous clinical trials.

Cethromycin is not approved as a treatment for CAP, and data from this analysis have not been reviewed by the FDA.

Update to Trial CL-05 Timeline

The Company also updated the projected timeline for the announcement of top-line data from the second pivotal Phase 3 CAP study, Trial CL-05. The Company expects to release top-line data from the second study, Trial CL-05, in September 2007. Due to s
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