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Advanced Cell Technology's Ability to Rescue Vision in Blind Rats,Noted in Scientific American

ALAMEDA, Calif.--(BUSINESS WIRE)--Mar 5, 2007 - Advanced Cell Technology, Inc.'s (OTCBB: ACTC) ability to rescue vision in blind rats was noted in Scientific American's March 2007 issue as the lead story of its News Scan section. The full text of the article, which notes Advanced Cell's ability to "coax embryonic stem cells to turn into transplantable retinal pigment epithelial (RPE) tissue," is timely as it comes shortly after the company announced its collaboration with the Casey Eye Institute at Oregon Health and Science University (OHSU).

The article is available at the following link: 99DF-3D2B8FC2C6B5D74C&colID=5 (Due to its length, this URL may need to be copied/pasted into your Internet browser's address field. Remove the extra space if one exists).

Mr. William M. Caldwell, IV, Chairman and CEO of Advanced Cell Technology commented, "We are pleased that Scientific American has taken note of Advanced Cell's progress. We are also excited about the many advantages offered by targeting the eye with RPE cells."

One of these advantages is the fact that the eye is immune-privileged, minimizing the use of immune suppressant drugs associated with other areas of the body that by definition reject foreign cells. The eye also requires only a small dosage of cells, reducing the amount necessary to be manufactured, which the company expects to be cost-effective in terms of trials. Another advantage is that the eye is a self-contained site, so the cells gravitate to the RPE layer. Since the site is contained, the cells are less likely to migrate beyond their target application, which could be the case if the site of application were in the blood stream. Additionally, the cells are easier to identify, because of their pigmentation, which is important for purity. Because the cells are easy to identify the risk of injecting forei gn, or non-RPE cells into the eye is greatly reduced. Further, age-related diseases of the eye can potentially affect every human being, and ACTC is hopeful that its efforts will help serve a large and growing market.

Mr. Caldwell continued, "Our collaborations at OHSU will be important as we initiate toxicology and pharmacology studies to be managed by our newly appointed Chief Development Officer, Dr. Pedro Huertas. These studies will be important milestones toward our anticipated filing of the company's first Investigational New Drug application (IND) with the FDA."

About Advanced Cell Technology, Inc.

Advanced Cell Technology, Inc. is a biotechnology company applying stem cell technology in the emerging field of regenerative medicine. The company operates facilities in Alameda, California and Worcester, Massachusetts. For more information about the company visit

Forward-Looking Statements

Statements in this news release regarding future financial and operating results, future growth in research and development programs, potential applications of our technology, opportunities for the and any other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not statements of historical fact (including statements containing the words "will," "believes," "plans," "anticipates," "expects," "estimates," and similar expressions) should also be considered to be forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by such forward-looking statements, including: limited operating history, need for future capital, risks inherent in the development and commercialization of potential products, protection of our intellectual property, and economic conditions generally. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in the company's periodic reports, including the report on Form 10-QSB for the quarter ended September 30, 2006.

Forward-looking statements are based on the beliefs, opinions, and expectations of the company's management at the time they are made, and the company does not assume any obligation to update its forward-looking statements if those beliefs, opinions, expectations, or other circumstances should change.


The Investor Relations Group
James Carbonara, 212-825-3210
Bill Douglass, 212-825-3210


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