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Adnexus Therapeutics Announces Presentation at the American,Association for Cancer Research (AACR) on Clinical Product,Candidate, CT-322

WALTHAM, Mass.--(BUSINESS WIRE)--Apr 17, 2007 - Adnexus(TM) Therapeutics, Inc. today announced the presentation of the abstract "CT-322: A specific VEGFR-2-blocking protein therapeutic agent with activity in preclinical tumor models comparable to pan-specific tyrosine kinase receptor inhibitors sunitinib and sorafenib" at the American Association for Cancer Research (AACR) 2007 annual meeting in Los Angeles, CA. The lead author is Irvith Carvajal, Ph.D., with Eric Furfine, Ph.D., senior vice president of research and preclinical development at Adnexus, presenting at the meeting.

CT-322 is a mono-specific blocker of the tyrosine kinase receptor, VEGFR-2, and blocks its activation by all known extracellular ligands; VEGF-A, VEGF-C, and VEGF-D. VEGFR-2 activation is the primary driver of tumor angiogenesis. In preclinical tumor models, CT-322 was compared to two approved pan-kinase inhibitors sunitinib and sorafenib. CT-322, sunitinib, and sorafenib each demonstrated comparable tumor growth suppression; however, CT-322 was better tolerated in the animal models.

"Our results suggest that 'pan-specific' kinase inhibitors may not offer improvement in anti-angiogenic induced tumor suppression over an extracellular, mono-specific blocker of VEGFR-2," commented Dr. Furfine. "CT-322's high affinity and selectivity for VEGFR-2 achieved comparable anti-tumor effect to molecules that inhibit a broad range of kinases."

"As cancer therapy evolves, the importance of efficacy, safety and tolerability of anti-angiogenic agents are becoming more pronounced due to the desire for combination therapy as well as longer duration of anti-angiogenic therapy," commented John Mendlein, Ph.D., chief executive officer of Adnexus. "We continue to extend our understanding of the VEGFR-2 pathway in tumor settings and its activation by VEGF-A, C and D. We are very encouraged by the emerging CT-322 Phase 1 data, and we look forward
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