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Addex Reports Positive Results in Phase IIa Clinical Trial With,ADX10059 in Migraine

ear, with an attack duration of between 4 and 72 hours. The prevalence of migraine is estimated at 12%, affecting approximately 30 million people in the United States. The disabling nature of migraine often results in a significant deterioration in quality of life for the sufferers and has a significant impact upon their work and family life. In the United States migraine is currently estimated to cost employers $13 billion annually in lost productivity. The total worldwide market for prescription migraine drugs was estimated at $2.4 billion in 2005, with the United States being the major market with sales of approximately $1.5 billion. The market is projected to increase to $2.7 billion by 2008. The mainstay of the prescription drug market for acute treatment of migraine in the last 10 years has been the triptan class of drugs, which are acute symptomatic treatments that have not been developed for use as migraine prevention agents. There is a significant unmet medical need for the latter, and an efficacious and well-tolerated medication with a neuronal rather than a vascular mechanism of action is currently considered by key opinion leaders to be the optimum drug profile for the prevention of migraine.

About Addex Pharmaceuticals

Addex Pharmaceuticals is an innovative company focused on the discovery and development of novel therapeutics that modulate the effect of natural activators on their specific targets, in particular G-Protein Coupled Receptors (GPCRs), in a non-competitive manner. The compounds are referred to as allosteric modulators and potentially offer advantages over conventional competitive agonist and antagonist compounds. This modulator principle is applicable to any GPCR, opening up a very wide variety of therapeutic opportunities. Addex is focusing its research and development on major indications with substantial unmet medical needs and significant commercial opportunities.

Addex has a portfolio of proprietary compounds in d
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