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Addex Achieves Statistically Significant Outcome in Phase IIa,Clinical Trial With ADX10059 in Gastro-Esophageal Reflux Disease

rect, as they suppress gastric acid production rather than prevent relaxation of the lower esophageal sphincter. Approximately 20% of patients with GERD either do not respond or are inadequately controlled by PPIs. Hence there remains a significant unmet need in the market for drugs with an alternative non-acid-suppressing mode of action. There are currently no licensed medications which act specifically to normalize the dysregulated function of the lower esophageal sphincter, and Addex believes that ADX10059 has the potential to become a first-in-class treatment for GERD.

About Addex Pharmaceuticals

Addex Pharmaceuticals is an innovative pharmaceutical company that discovers and develops novel therapeutics that modulate the effect of natural activators on their specific targets, in particular G-Protein Coupled Receptors (GPCRs), in a non-competitive manner. The compounds are referred to as allosteric modulators and potentially offer advantages over conventional competitive agonist and antagonist compounds. This modulator principle is applicable to any GPCR, opening up a very wide variety of therapeutic opportunities. Addex is focusing its research and development on major indications with substantial unmet medical needs and significant commercial opportunities.

Addex has a portfolio of proprietary compounds in discovery and development for GERD, migraine, anxiety, smoking cessation, depression, pain, cognitive impairment, schizophrenia, Parkinson's disease, contraception and diabetes type 2. Addex's competence in drug development and its expertise in allosteric modulation were recognised through the establishment of a partnership for co-development of mGluR2 positive allosteric modulators for anxiety and schizophrenia with Johnson & Johnson in 2004.

CONTACT: For further information, please contact: Christophe Lamps orJonathan Leighton, Rochat & Partners, Tel: +41-22-786-54-55. KatiaSpartalli, Addex Pharmaceuticals, Tel: +41-22-88
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