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Actelion Announces Positive Study with Bosentan (Tracleer) in,CTEPH

ficant improvements in hemodynamic parameters that suggest positive patient benefits, as demonstrated by the significant improvements in breathlessness during exercise. Accordingly, we will discuss these findings with healthcare authorities worldwide."

Professor Lewis J. Rubin, University of California, San Diego, La Jolla/USA and a member of the BENEFiT steering committee added: "This first randomized placebo-controlled study in this inoperable patient population gives us a clear understanding how to improve medical care for these patients that are otherwise left without any options. Significant improvements in PVR and shortness of breath at exercise are matched by a significant decrease in NT-proBNP, an indicator of disease severity.

This study, therefore, also helps us in further advancing our understanding of both the disease and the appropriate way to evaluate therapeutic agents in pulmonary hypertension." Professor Gérald Simonneau, from the Hôpital Antoine Béclère, Paris, and lead investigator of the study commented: "For the BENEFiT study, we have chosen the pulmonary vascular resistance as primary objective as we use this key hemodynamic parameter to guide us in our daily medical management of CTEPH patients. Bosentan has now demonstrated a significant impact on this important parameter. Accordingly, bosentan might offer a new therapeutic option in these patients who cannot undergo surgery." CTEPH and bosentan (Tracleer®) findings in BENEFiT CTEPH is caused by obstruction of the pulmonary arteries by organized persistent thrombi leading to increased pulmonary vascular resistance, progressive pulmonary hypertension and ultimately right-heart failure. Pulmonary endarterectomy (PEA) is the preferred treatment for CTEPH for suitable patients.

Nevertheless, up to half of all CTEPH patients cannot undergo surgery due to the nature of the disease and the location of the thrombi 1. Following surgery, 10-15% of pat
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