Navigation Links
Access Pharmaceuticals Announces Poster Presentations on ProLindac,at the American Association for Cancer Research 2007 Annual Meeting

nalog). This provides an early indication that ProLindac can effectively substitute for oxaliplatin in combination therapies. While this study shows that ProLindac and oxaliplatin have similar cytotoxicities on an equimolar basis, in vivo studies reported elsewhere demonstrate that much higher doses of ProLindac can be administered compared to oxaliplatin. Therefore, based on the data presented here, ProLindac has potential for superior efficacy in vivo. This work was conducted primarily at the Department of Medical Oncology, Hospital Beaujon, Clichy, France.

The second poster is entitled "Preclinical study of the transport and intracellular distribution of ProLindac, a novel diaminocyclohexane-platinum (DACH-Pt) tumor-targeting drug delivery system." This poster describes studies which examine the transportation and distribution of ProLindac in human cancer cell lines and the rate of formation of -platinum-DNA-adducts. It is the formation of such adducts which appears to be a major contributor to the anticancer activity of platinum drugs. High levels of these adducts are formed when tumor cells are exposed to ProLindac. Incubation of tumor cells with ProLindac resulted in an increase in G2/M phase and apoptosis in human cancer cell lines. Both of these effects are associated with antitumor activity. Intracellular concentrations of platinum in HCT-116 tumor cells were about 10-fold greater when the incubating medium pH was lowered from 7.0 to 5.4. Previously Access had shown a faster release of platinum as pH is lowered in a simple aqueous system. This study confirms that tumor cell uptake of platinum from ProLindac is enhanced as pH is lowered; lowered pH is typically seen in hypoxic tumors. This work was conducted primarily at the Rene Huguenin Cancer Center, Saint-Cloud, France.

About ProLindac(TM)

Access' lead compound, ProLindac(TM), is a novel DACH platinum prodrug which has been shown to be active in a wide variety of solid tumors in both
'"/>




Page: 1 2 3 4

Related medicine technology :

1. PromegaExpress Expands Easy Access to Products with New Cabinet
2. Access and Somanta Announce Data to be Presented on Angiolix at ASCO Oncology Conference
3. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
4. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
6. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
7. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
8. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
9. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
10. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
11. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
Post Your Comments:
(Date:9/30/2014)... -- Headquartered in Anaheim, California , ... of several specialized partners focused on leveraging the power ... of its team of professionals to improve the fundamental ... more than 10 professional diagnostic tests for hospitals, doctors, ... retail consumer tests is proud to announce an addition ...
(Date:9/30/2014)... WASHINGTON , Sept. 30, 2014  The ... nurse managers to call them at 866-714-6466 if ... admitting Medicare patients, who should have been sent ... The reward potential can be substantial, as the ... Photo - http://photos.prnewswire.com/prnh/20140929/149016 ...
(Date:9/30/2014)... Sept. 30, 2014  eHealth, electronic access of ... access of this information, has become a major ... that has not translated into user-friendly, effective products. ... - http://photos.prnewswire.com/prnh/20140929/149123 For ... years developing MWD® Health Manager iEHR, a multilingual ...
Breaking Medicine Technology:WholeHealth Products Announces The Discovery Of The "Autism And Fragile X" Microwell And Rapid Diagnostic Test 2Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 2Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 3Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 4MWD Challenges the Big eHealth Players With New Software for Your Smartphone 2
... Percutaneous Administration (CUPID) Data Highlight Safety Profile and ... 26 Celladon Corporation today announced that results ... advanced heart failure, including Phase 1/2 data of ... Zsebo, PhD, President and CEO, Celladon Corporation and ...
... 26 Senesco Technologies, Inc. ("Senesco" or the "Company") ... mouse influenza survival studies that were conducted in Dr. William Scheld,s ... Mice treated with an siRNA against Senesco,s Factor 5A gene ... rate for mice that received no treatment or a control siRNA.A ...
Cached Medicine Technology:Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy 2Senesco Announces H1N1 Influenza Survival Test Results in Mice 2Senesco Announces H1N1 Influenza Survival Test Results in Mice 3
(Date:9/30/2014)... Dennis Thompson HealthDay Reporter ... day, people receive medical implants -- artificial valves, hip ... have been rigorously tested before or after their approval by ... The studies -- conducted by prominent nonprofit groups and ... -- lay the blame for inadequate medical device testing on ...
(Date:9/30/2014)... 30, 2014 Houstonians seeking the latest ... to visit on the Internet. Paul Vitenas, JR. ... respected cosmetic surgeons, has launched a new website to ... of Botox Cosmetic services. The new website ... According to the new website, Botox Cosmetic is a ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Neuromuscular ... people throughout the United States and worldwide. It ... Disease are diagnosed each year, adding to the ... the disease. Approximately 400,000 people in the US ... worldwide. Add to these statistics the 2.4 percent ...
(Date:9/30/2014)... Gummy teeth treatment expert, ... for dark gums. Dark gums are usually considered a ... self-conscious about their smiles. Dr. Farnoosh has pioneered a ... one of the few dental professionals nationwide offering black ... business leaders, high-ranking officials and patients from all over ...
(Date:9/30/2014)... 30, 2014 (HealthDay News) -- Herceptin is the best ... HER2-positive and should remain the standard of care for ... a long-term clinical trial. HER2-positive breast cancers tend ... cancer, according to the Mayo Clinic. For the ... either Herceptin (trastuzumab) or Tykerb (lapatinib) in addition to ...
Breaking Medicine News(10 mins):Health News:Medical Implant Devices Skate Through Review Process, Studies Claim 2Health News:Medical Implant Devices Skate Through Review Process, Studies Claim 3Health News:Medical Implant Devices Skate Through Review Process, Studies Claim 4Health News:Dr. Paul Vitenas Launches New Website To Showcase The Benefits Of Botox Cosmetic 2Health News:Dr. Paul Vitenas Launches New Website To Showcase The Benefits Of Botox Cosmetic 3Health News:North American Seminars Introduces a New OT PT CME Course, Evidence Based Rehab Techniques for Parkinsons, Multiple Sclerosis and Peripheral Neuropathy 2Health News:North American Seminars Introduces a New OT PT CME Course, Evidence Based Rehab Techniques for Parkinsons, Multiple Sclerosis and Peripheral Neuropathy 3Health News:Gummy Smile Dentist, Dr. Alex Farnoosh, is Now Offering Gum Depigmentation for Dark Gums 2
... (CLP) at Thomas Jefferson University Hospital, recently received an ... scope of the normal duties of serving as ... American College of Surgeons Commission on Cancer (CoC). ... appointment and is among a national network of over ...
... ... Use Dashboard will provide a single location where an organization can see, at a ... ... 2010 -- Health Care DataWorks , a Technology Company created to commercialize the ...
... finds they are equal to artery-clearing surgery, but another ... -- Both stents and conventional surgery appear to be ... arteries are blocked, according to research presented Friday at ... , However, a second stents-versus-surgery trial, published Thursday in ...
... ... company, has signed a strategic partnership agreement with Medical Insight to complete the ... capability across the healthcare enterprise. , , ... Milwaukee (PRWEB) February 26, 2010 -- ...
... The natural-occurring biopolymer known as chitosan is being put ... the diet of ruminants, according to research carried out ... presence of these antibiotics as additives in the diet ... since 2006, given that their use is linked to ...
... ... ... ... ...
Cached Medicine News:Health News:Jefferson surgeon receives outstanding performance award from American College Of Surgeons 2Health News:HCD Announces Meaningful Use Dashboard for Health Systems 2Health News:Stents May Be Effective Weapon Against Stroke 2Health News:Stents May Be Effective Weapon Against Stroke 3Health News:Stents May Be Effective Weapon Against Stroke 4Health News:TeraMedica Inks Reseller Agreement With Medical Insight Enterprise Image Viewer Company 2Health News:TeraMedica Inks Reseller Agreement With Medical Insight Enterprise Image Viewer Company 3Health News:Chitosan as alternative to growth-promoting antibiotics for ruminants 2Health News:Chitosan as alternative to growth-promoting antibiotics for ruminants 3Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 2Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 3Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 4Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 5
Manufactured with large, shatter-resistant Clear Pb leaded acrylic panels which provide a wide field of vision for one or more users. Opaque lower panels are covered in your choice of decorative viny...
... Excellent for patient protection ... erect chest and cervical spine. ... 0.5mm shield. Height adjustable 36" ... sturdy star-leg aluminum base for ...
RayShield Frame Mounted Overhead Lead Acrylic Barriers are offered in a choice of three sizes: 60 cm x 80 cm ( 24" x 32") wide, 60 cm x 50 cm( 24" x 20") wide. Lead acrylic windows of 0.5 mm and 1.0 ...
Ball-and-socket center mount can rotate 360, allowing them to be turned hoirzontally, vertically, or at any angle. Very versatile! Available with or without torso placement contour cutout and in thre...
Medicine Products: