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Access Pharmaceuticals Announces Poster Presentations on ProLindac,at the American Association for Cancer Research 2007 Annual Meeting

nalog). This provides an early indication that ProLindac can effectively substitute for oxaliplatin in combination therapies. While this study shows that ProLindac and oxaliplatin have similar cytotoxicities on an equimolar basis, in vivo studies reported elsewhere demonstrate that much higher doses of ProLindac can be administered compared to oxaliplatin. Therefore, based on the data presented here, ProLindac has potential for superior efficacy in vivo. This work was conducted primarily at the Department of Medical Oncology, Hospital Beaujon, Clichy, France.

The second poster is entitled "Preclinical study of the transport and intracellular distribution of ProLindac, a novel diaminocyclohexane-platinum (DACH-Pt) tumor-targeting drug delivery system." This poster describes studies which examine the transportation and distribution of ProLindac in human cancer cell lines and the rate of formation of -platinum-DNA-adducts. It is the formation of such adducts which appears to be a major contributor to the anticancer activity of platinum drugs. High levels of these adducts are formed when tumor cells are exposed to ProLindac. Incubation of tumor cells with ProLindac resulted in an increase in G2/M phase and apoptosis in human cancer cell lines. Both of these effects are associated with antitumor activity. Intracellular concentrations of platinum in HCT-116 tumor cells were about 10-fold greater when the incubating medium pH was lowered from 7.0 to 5.4. Previously Access had shown a faster release of platinum as pH is lowered in a simple aqueous system. This study confirms that tumor cell uptake of platinum from ProLindac is enhanced as pH is lowered; lowered pH is typically seen in hypoxic tumors. This work was conducted primarily at the Rene Huguenin Cancer Center, Saint-Cloud, France.

About ProLindac(TM)

Access' lead compound, ProLindac(TM), is a novel DACH platinum prodrug which has been shown to be active in a wide variety of solid tumors in both
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