Navigation Links
Accelreon Pharma's ACE-031Shown to Increase Muscle Mass in,Preclinical Studies

LUCCA, ITALY, ­ May 14, 2007-Acceleron Pharma, Inc., a biopharmaceutical company developing therapeutics for the treatment of musculoskeletal, metabolic and cancer-related diseases, today announced results of a preclinical study with ACE-031 that demonstrated the ability of the compound to increase muscle mass and strength in normal mice and in murine models of muscular dystrophy. ACE-031 inhibits negative regulators of muscle to increase muscle mass and strength as a potential treatment for neuromuscular diseases and cancer-related muscle loss. The data was presented on Sunday, May 13 at the Gordon Research Conference on Myogenesis in Lucca, Italy. ³

Acceleron is encouraged by the significant outcomes and positive data generated by ACE-031 spanning numerous preclinical models of muscle loss², said Jas Seehra, Ph.D., Chief Scientific Officer of Acceleron. ³ACE-031 and related Acceleron compounds consistently demonstrate substantial increases in skeletal muscle mass and strength.² ACE-031, a protein therapeutic based on the activin receptor type IIB (ActRIIB), is the first of several compounds Acceleron is developing for the treatment of diseases involving the loss of muscle mass, strength and function. ActRIIB binds to myostatin (GDF-8) and other negative regulators of muscle mass and strength. Over-expression of myostatin has been shown to cause a loss in muscle mass and strength, and inhibition of myostatin results in the selective increase in skeletal muscle mass and strength. In preclinical models, ACE-031 increased skeletal muscle mass and strength in disease models of amyotrophic lateral sclerosis (ALS), muscular dystrophy, glucocorticoid-induced muscle loss and age-related muscle loss (sarcopenia).

ACE-031 offers the potential for an entirely new type of therapy for the treatment of various muscle wasting conditions. ³The clinical potential of ACE-031 to selectively increase skeletal muscle will offer
'"/>




Page: 1 2 3

Related medicine technology :

1. Acceleron Pharmas ACE-031 Increases Muscle Mass and Strength in Preclinical Studies
2. Integrated BioPharmas Proprietary Vaccine Technology Achieves Strong Positive Results
3. Rapid HIV Testing Increases Possibility of Treatment
4. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
5. ProtoKinetixs AAGP Dramatically Increases Recovery Rate of Cryopreserved Stem Cells
6. Blood Levels of Paliperidone Extended-Release Tablets are Not Increased by Common Antidepressant
7. Auxilium Announces New Data That Show Total Testosterone Blood Levels Increase Significantly Following Switch from AndroGel(R) to Testim(R)
8. New Data On the Probiotic Strain Bifantis Shows Anti-Inflammatory Properties and Increased Health Benefits
9. MabThera Significantly Increases Survival of Lymphoma Patients Regardless of Chemotherapy Regimen
10. Abraxis BioScience Presents Data from Pre-Clinical Study That Provide Evidence for Chemotherapy-Induced Angiogenesis and Rationale for Combining nab-Paclitaxel (Abraxane) with Anti-Angiogenic Agents to Increase Tumor Response
11. Data Published in Neurology Showed That Higher Dose of Copaxone Increased Efficacy in Relapsing-Remitting Multiple Sclerosis (RRMS)
Post Your Comments:
(Date:3/27/2015)... MARLBOROUGH, Mass. , March 27, 2015 ... ) and privately-held MirImmune LLC, today announced ... license agreement to RXi,s novel and proprietary ... cell-based cancer immunotherapies. The collaboration has the ... and patient friendly cancer treatments that could ...
(Date:3/27/2015)... RnRMarketResearch.com adds "Visceral Pain ... report of 52 pages with latest updates, data ... The report "Visceral Pain - Pipeline Review, H1 ... for Visceral Pain, complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ...
(Date:3/27/2015)... Concord Medical Services Holdings Limited ("Concord ... a leading specialty hospital management solution provider and ... diagnostic imaging centers in China ... agreement under which Concord Medical Services (International) Pte ... agreed to acquire the Fortis Surgical Hospital from ...
Breaking Medicine Technology:RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 2RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 3RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 5Visceral Pain Pipeline Review H1 2015 Market Research Report 2Visceral Pain Pipeline Review H1 2015 Market Research Report 3Visceral Pain Pipeline Review H1 2015 Market Research Report 4Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3
... 25, 2012 Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... quarter 2012 financial results after the Nasdaq market closes on ... conference call and webcast to discuss its financial results and ... 5:00 p.m. Eastern Time (2:00 p.m. Pacific Time). ...
... 25, 2012 STAAR Surgical Company (NASDAQ: STAA ) today ... ended March 30, 2012 on Wednesday, May 2, 2012 ... a conference call and webcast on Wednesday, May 2, 2012 ... to discuss the Company,s first quarter 2012 results and recent ...
Cached Medicine Technology:STAAR Surgical Announces First Quarter 2012 Results Release Date and Conference Call and Webcast 2
(Date:3/28/2015)... Delaying rotator cuff surgery on patients with ... presented today at the American Orthopaedic Society for Sports ... compared results for 170 patients who received rotator cuff ... capsule release procedure to relieve stiffness at the time ... from St. George Hospital in Sydney, Australia. “Both groups ...
(Date:3/28/2015)... NC (PRWEB) March 28, 2015 Genomic ... with peritoneal mesothelioma, revealing, for the first time, key ... Click here to read the newly posted story ... at the University of British Columbia, the British Columbia ... genome mapping to reveal underlying molecular alterations and mutations ...
(Date:3/28/2015)... Lately the student-athlete experience ... and proposals around the NCAA. In a March episode ... student-athletes across a spectrum of universities and sports shed ... The special panel consists of athletes who have competed ... football, track and field, baseball, and volleyball. They discuss ...
(Date:3/28/2015)... Mirada, CA (PRWEB) March 28, 2015 ... ear, nose and throat disorders, are now ... is a common issue which is characterized by the ... Affecting 1 in 5 people, tinnitus is a prevalent ... disorder and while it is non-fatal, tinnitus can impede ...
(Date:3/28/2015)... Designers and Professionals of FCPX plugins ... from Pixel Film Studios. , “Scratches 5K allows users ... Final Cut Pro X” Said Christina Austin, CEO of ... an effective tool for any FCPX editor.” , Scratch ... grunge overlays. Simply drag title layers into the FCPX ...
Breaking Medicine News(10 mins):Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:New Genomics Research May Help Doctors Tailor Mesothelioma Treatment, According to Surviving Mesothelioma 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 3Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2Health News:Pixel Film Studios Unveiled Scratches 5k for Final Cut Pro X Editors 2
... in the Sun Volunteers Mount Winning Effort to Fight Skin Cancer, ... ... Creamer Triumphs, HALF MOON BAY, Calif., Oct. 17 ... up at the recent LPGA,s Samsung,World Championship in Half Moon Bay, CA ...
... centuries civilizations have,flocked to warm bubbly waters to soothe ... high tech home spas of today that can cost,anywhere ... economic uncertainty,is a backyard water oasis simply a luxury ... science behind the soak?, To view the Multimedia ...
... identify those most at risk from hair loss is now available in ... ... 17, 2008 -- A groundbreaking genetic test to identify those most at ... men and women. , , ,Currently only available at Farjo Hair ...
... to Combat Blindness, LISBON, Portugal and NEW ... the largest global science foundations, invites all,institutions working ... for the,Antonio Champalimaud Vision Award. The Award is ... of blindness and,visual impairment. The prestigious Award, which ...
... Americans United for Life,(AUL) today filed an amicus ... of the deadly abortion drug, RU-486., AUL President ... of ruining and even ending women,s lives. We must ... drug. Ohio,s statute is a,step in the right direction, ...
... fixed incomes are particularly challenged by rising expenses, including housing, healthcare ... ... Belleville, Ill. (Vocus) October 16, 2008 -- For the more than ... awaiting a decision on their application for benefits, the 5.8 percent ...
Cached Medicine News:Health News:Sun Safety Champions Team Up With LPGA Tour Pro Paula Creamer 2Health News:Sun Safety Champions Team Up With LPGA Tour Pro Paula Creamer 3Health News:Sun Safety Champions Team Up With LPGA Tour Pro Paula Creamer 4Health News:Video: The Science Behind the Soak - a Coping Tool for Today's Changing World 2Health News:Breakthrough Baldness Genetic Test 2Health News:The Champalimaud Foundation Invites Nominations and Applications for Its 2009 Vision Award 2Health News:The Champalimaud Foundation Invites Nominations and Applications for Its 2009 Vision Award 3Health News:Ohio's Regulation of RU-486 Clear and Constitutional, Should Be Upheld Argues AUL in Brief Filed Before Ohio Supreme Court 2Health News:Social Security 2009 COLA Helps, But People with Disabilities Will Still Struggle, Says Allsup 2Health News:Social Security 2009 COLA Helps, But People with Disabilities Will Still Struggle, Says Allsup 3Health News:Social Security 2009 COLA Helps, But People with Disabilities Will Still Struggle, Says Allsup 4Health News:Social Security 2009 COLA Helps, But People with Disabilities Will Still Struggle, Says Allsup 5Health News:Social Security 2009 COLA Helps, But People with Disabilities Will Still Struggle, Says Allsup 6Health News:Social Security 2009 COLA Helps, But People with Disabilities Will Still Struggle, Says Allsup 7
... Reposable system components for creating each access port are ... is packaged sterile together with either a 5 mm ... needle is packaged non-sterile; 5 mm, 7/8 mm, ... 5 mm, 7/8 mm, 10 mm and 12 ...
VERSAPORT™ Plus RT Single Use Obturators for use with VERSAPORT™ RT Reusable Cannulae....
The SURGINEEDLE™ is a veress type needle that is used to insufflate the abdomen to create pneumoperitoneum....
... complete line of Surgical Access ...unlike any ... OnePort™ trocar system is actually four systems ... operationally flexible and clinically adaptive to all ... in disposability and bladed or dilating tip ...
Medicine Products: