Navigation Links
Acceleron Pharma's ACE-031 Increases Muscle Mass and Strength in,Preclinical Studies

LUCCA, Italy--(BUSINESS WIRE)--May 14, 2007 - Acceleron Pharma, Inc., a biopharmaceutical company developing therapeutics for the treatment of musculoskeletal, metabolic and cancer-related diseases, today announced results of a preclinical study with ACE-031 that demonstrated the ability of the compound to increase muscle mass and strength in normal mice and in murine models of muscular dystrophy. ACE-031 inhibits negative regulators of muscle to increase muscle mass and strength as a potential treatment for neuromuscular diseases and cancer-related muscle loss. The data was presented on Sunday, May 13 at the Gordon Research Conference on Myogenesis in Lucca, Italy.

"Acceleron is encouraged by the significant outcomes and positive data generated by ACE-031 spanning numerous preclinical models of muscle loss", said Jas Seehra, Ph.D., Chief Scientific Officer of Acceleron. "ACE-031 and related Acceleron compounds consistently demonstrate substantial increases in skeletal muscle mass and strength."

ACE-031, a protein therapeutic based on the activin receptor type IIB (ActRIIB), is the first of several compounds Acceleron is developing for the treatment of diseases involving the loss of muscle mass, strength and function. ActRIIB binds to myostatin (GDF-8) and other negative regulators of muscle mass and strength. Over-expression of myostatin has been shown to cause a loss in muscle mass and strength, and inhibition of myostatin results in the selective increase in skeletal muscle mass and strength. In preclinical models, ACE-031 increased skeletal muscle mass and strength in disease models of amyotrophic lateral sclerosis (ALS), muscular dystrophy, glucocorticoid-induced muscle loss and age-related muscle loss (sarcopenia). ACE-031 offers the potential for an entirely new type of therapy for the treatment of various muscle wasting conditions.

"The clinical potential of ACE-031 to selectively increase
'"/>




Page: 1 2 3

Related medicine technology :

1. Accelreon Pharmas ACE-031Shown to Increase Muscle Mass in Preclinical Studies
2. Integrated BioPharmas Proprietary Vaccine Technology Achieves Strong Positive Results
3. Rapid HIV Testing Increases Possibility of Treatment
4. ProtoKinetixs AAGP Dramatically Increases Recovery Rate of Cryopreserved Stem Cells
5. MabThera Significantly Increases Survival of Lymphoma Patients Regardless of Chemotherapy Regimen
6. Researchers Discover a Common Variation in a Gene Segment that Increases the Risk for Prostate Cancer
7. New Data on Market-Leading Velcade (Bortezomib) for Injection Further Strengthen Role in Previously Treated Multiple Myeloma
8. SPIRIT Clinical Data Reaffirm Strength of Taxus and Promus Drug-Eluting Coronary Stent Systems
9. EntreMeds Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models
10. Data Presented at AACR Meeting Shows Peregrines Immunocytokine Fusion Proteins Reduce Growth of B-Cell Lymphoma Tumors by 85% in Preclinical Studies
11. Data Presented at AACR Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Growth of Both Hormone-Dependent and Hormone-Independent Prostate Cancer by Up to 94 Percent in Preclinical Studies
Post Your Comments:
(Date:12/17/2014)... LOS ANGELES , Dec. 17, 2014 /PRNewswire/ ... that the US Patent and Trademark Office (USPTO) ... candidate ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting ... glioblastoma. The claims of US Patent No. 8,871,211, ... treating neural cancer by administering a dendritic cell ...
(Date:12/17/2014)...  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... and commercializing innovative therapies addressing major unmet medical ... in its first Phase 2a study, RXI-109-1301.  The ... 1-month findings that were reported in September of ... http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , , , ...
(Date:12/17/2014)... PCCA received the Autism Hope Alliance,s ... program seal for best practices in meeting needs ... practices, materials and goods that meet strict criteria ... affected by autism often have unique physical or ... found in food and medicine – for instance ...
Breaking Medicine Technology:ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3
... Watt Poultry USA states that acidic treatments benefit poultry ... ... Antimicrobial Solution,which is used to reduce pathogens during poultry processing, was ... solve the,"yield/pathogen reduction dilemma." Citing recent studies in large-scale processing ...
... In,recognition of her research and development of ... South-African and,Latino youth and adults, the Honor Society ... of Loretta Sweet Jemmott, PhD, RN,FAAN, to receive ... Jemmott was presented with the $15,000 award at ...
Cached Medicine Technology:FreshFx Recognized for use in the Scalder as a Solution to the 'Yield/Pathogen Reduction Dilemma' 2Honor Society of Nursing Recognizes Researcher of HIV Risk Prevention for Poor and Underserved 2Honor Society of Nursing Recognizes Researcher of HIV Risk Prevention for Poor and Underserved 3
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... to the H1N1 flu, most employees at U.S. businesses say ... as encouraging sick employees to stay home, according to a ... Research Program at Harvard School of Public Health (HSPH). Smaller, ... other actions such as creating back-up systems for employees to ...
... good place to offer education on kids, nutrition, researcher says ... consumption of sugary drinks appear to be linked to rising ... has found. , Researchers looked at 65 children, aged 2 ... and found that nearly 28 percent of those kids had ...
... ... small-to-medium businesses in the Greater Houston area better prepare and protect themselves in the event ... ... disaster recovery planning, launched two new online tools to help small-to-medium businesses (SMB,s) in the ...
... tooth decay may be more likely to be overweight or ... more likely to consume too many calories, a new study ... Society,s 92nd Annual Meeting in San Diego. "Poor eating ... obesity in preschoolers," the study,s lead author, Kathleen Bethin, MD, ...
... Migrant children are at increased risk of obesity, but a ... to predominantly migrant preschoolers and their parents helps the children ... presented Monday at The Endocrine Society,s 92nd Annual Meeting in ... curb the global obesity epidemic, the study,s lead author Jardena ...
... ... new office in North Hollywood. Many California residents are now able to benefit from the competent ... ... Angeles dentist , is proud to announce the opening of his new office location in North ...
Cached Medicine News:Health News:Employers took many measures to protect employees and avoid business impact of H1N1 flu outbreak 2Health News:Employers took many measures to protect employees and avoid business impact of H1N1 flu outbreak 3Health News:Employers took many measures to protect employees and avoid business impact of H1N1 flu outbreak 4Health News:Cavities in Baby Teeth May Come From Poor Food Choices 2Health News:X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses 2Health News:Study shows a possible link between preschoolers' cavities and excess body fat 2Health News:Lifestyle intervention reduces preschoolers' body fat, improves fitness 2Health News:Trusted Los Angeles Dentist, Dr. Bijan Afar, is Now Practicing in Hollywood Area 2Health News:Trusted Los Angeles Dentist, Dr. Bijan Afar, is Now Practicing in Hollywood Area 3
Medpor Sphere Inserter. The Inserter is provided as a value added item to Medpor Orbital Implants....
Reusable cannula with .90 mm (20 g) shaft, tapering to .60 mm (23 g) 3 mm from the tip. Overall length is 29 mm....
Blunt cannula for injection or aspiration of fluid. Thinwall cannula allows high flow rate. Blunt tip is smooth all around for easy insertion. Luer lock hub for easy, secure connection to a backflus...
PLX30s, 30 Watt Sealed CO2 Laser System....
Medicine Products: