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Abraxis BioScience Presents Data from Pre-Clinical Study That,Provide Evidence for Chemotherapy-Induced Angiogenesis and,Rationale for Combining nab-Paclitaxel (Abraxane) with,Anti-Angiogenic Agents to Increase Tumor Response

LOS ANGELES--(BUSINESS WIRE)--Apr 19, 2007 - Abraxis BioScience, Inc. (NASDAQ:ABBI), an integrated, global biopharmaceutical company, discussed results from two pre-clinical studies that provide evidence for chemotherapy induced angiogenesis and rationale for combining nab-paclitaxel (ABRAXANE(R) for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound)) with VEGF inhibitor drugs like bevacizumab (Avastin(R)) at the 98th American Association for Cancer Research (AACR) Annual Meeting held April 14-18, 2007 in Los Angeles.

The first of two pre-clinical studies investigating mechanistic aspects of chemotherapy induced angiogenesis showed for the first time that nab-paclitaxel, as well as standard chemotherapies like solvent-based paclitaxel (Taxol(R)) and doxorubicin, can trigger reactionary angiogenesis with concomitant increased secretion from tumors of angiogenic factors, such as VEGF. This 'reactionary angiogenesis' provides a strong mechanistic rationale for combination of nab-paclitaxel therapy with the VEGF inhibitor drugs, such as bevacizumab, to enhance the antitumor response. (Abstract #4636; Investigation of Chemotherapy-induced Tumor Angiogenesis: Rationale for Combination of nab-paclitaxel with Anti-VEGF Therapy).

The second pre-clinical study, which investigated tumor regression and metastasis, found that the combination of nab-paclitaxel with bevacizumab in breast cancer tumor models showed significantly enhanced anti-tumor response with a significantly reduced frequency of metastasis to the lymph nodes and lungs as compared to single agent therapy. (Abstract #2201; The Role of VEGF in Chemoprotection and Tumor Metastasis: Rationale for Combination of nab-paclitaxel and bevacizumab). Both studies demonstrate the potential of nab-paclitaxel in combination with bevacizumab as an effective antitumor agent.

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