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Abbott's Xience V Everolimus Eluting Coronary Stent Superior to,Taxus Stent in Spirit III U.S. Pivotal Clinical Trial

- XIENCE V Demonstrates Superiority in Primary Endpoint of In-Segment Late Loss, Non-Inferiority in Major Secondary Endpoint of Target Vessel Failure and Superiority in Major Adverse Cardiac Events (MACE) in the SPIRIT III U.S. Trial -

ABBOTT PARK, Ill., March 24, 2007 /PRNewswire-FirstCall/ -- Data presented today from Abbott's SPIRIT III U.S. pivotal clinical trial at the of Cardiology's 56th Annual Scientific Session in New Orleans demonstrated the following key results:

    --  The randomized SPIRIT III trial of 1,002 patients comparing Abbott's

        next-generation XIENCE(TM) V Everolimus Eluting Coronary Stent System

        with the TAXUS(R) paclitaxel-eluting coronary stent system met both

        its primary endpoint and major secondary endpoint.

    --  In its primary endpoint of in-segment late loss at eight months,

        XIENCE V demonstrated superiority to TAXUS with a statistically

        significant 50 percent reduction in late loss compared to TAXUS (0.14

        +/- 0.41 mm XIENCE V, 0.28 +/- 0.48 mm TAXUS, p superior =0.004).

        In-segment late loss is a measure of vessel renarrowing.

    --  In its major secondary endpoint of Target Vessel Failure at nine

        months, XIENCE V demonstrated non-inferiority to TAXUS with an

        observed 21 percent reduction in Target Vessel Failure for XIENCE V

        compared to TAXUS (7.2 percent XIENCE V, 9.0 percent TAXUS, p non-

        inferior <0.0001).  Target Vessel Failure is a measure of re-treatment

        anywhere within the target vessel and includes cardiac death or heart

        attack.

    --  Subsequent to SPIRIT III meeting its primary and major secondary

        endpoints, an analysis of nine-month Major Adverse Cardiac Events

        (MACE), such as cardiac death, heart attack or target lesion

        revascularization (artery re-treatment due to lack of blood supply),

        was undertaken in which XIENCE V demonstrated superiority to TAXUS

'"/>




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