( reduction in poly(ADP-ribose) po...)Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer,Health

reduction in poly(ADP-ribose) polymer by ELISA" [Oral presentation, Tuesday, April 17, 2:40 p.m., Room 404 A-B] -- "ABT-888, a potent PARP inhibitor, enhances the antitumor activities by a variety of chemotherapeutic agents in vivo" [Poster session, Abstract #1457, Sunday, April 15, 1 p.m. - 5 p.m., Poster section 28, Poster 14, Exhibit Hall]

"Cancer accounts for nearly 25 percent of all deaths in the United States, second only to heart disease," said Stephen Fesik, Ph.D., divisional vice president, Cancer Research, Abbott. "Abbott's Oncology Discovery team is dedicated to finding the next generation of small molecule and biologic therapies that will have an impact on this horrible disease."

"There is particular excitement from the scientific community surrounding Abbott's Bcl-2 family protein inhibitors which block the action of a class of proteins that regulate apoptosis," said Fesik. "This ground-breaking program may prove to be extremely valuable in the fight against cancer. In fact, dozens of researchers from around the world are studying Abbott's Bcl-2 family protein inhibitors and will reveal some of their results at this meeting."

Background on Abbott's Oncology Pipeline

Bcl-2 Family Protein Inhibitors (ABT-263)

Researchers have been interested in the Bcl-2 family of proteins since their role in preventing apoptosis -- the natural process by which damaged or unwanted cells die and are cleared from the body -- was proven more than a decade ago. Discovered by Abbott scientists, ABT-263 restores programmed cell death, a natural mechanism for the elimination of cancerous cells, by inhibiting the function of Bcl-2 proteins.

Bcl-2 proteins play a central role in regulating apoptosis, as well as tumor formation, tumor growth and resistance to treatment. Pioneering work in structural biology at Abbott established how
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