Navigation Links
Abbott Researchers Focus on New Cutting-Edge Approaches in the,Fight Against Cancer

Scientists to Present Data on Innovative Oncology Compounds at the American Association for Cancer Research Annual Meeting

ABBOTT PARK, Ill., April 13, 2007 /PRNewswire-FirstCall/ -- For decades, scientists have looked for new therapies that target cancer. Researchers now know that cancer cells have several unique characteristics -- they require new blood vessels to deliver oxygen and nutrients (angiogenesis), they grow uncontrollably (proliferation), they travel throughout the body (metastasis), and they escape programmed cell death, a natural process by which the body rids itself of damaged or unwanted cells (apoptosis). Robust preclinical data shows that several compounds in Abbott's oncology pipeline interfere with these vital processes. Data on two of these compounds will be presented at the American Association for Cancer Research (AACR) Annual Meeting being held April 14-18 in Los Angeles.

During the meeting, scientists from independent academic institutions and Abbott will present data on Abbott's Bcl-2 family protein inhibitor (ABT-263). This compound, currently in early clinical development, corrects defects in cancer cells that allow them to escape programmed cell death. They will also present data on an investigational PARP inhibitor (ABT-888) that enhances the effectiveness of common cancer therapies that damage DNA in cancer cells.

    Presentation highlights include:


    --  "ABT-263:  An orally bioavailable Bcl-2 family protein inhibitor"

        [Oral presentation, Sunday, April 15, 1 p.m., Hall A]

    --  "Pediatric preclinical testing program (PPTP) evaluation of the Bcl-2

         inhibitor ABT-263"

        [Oral presentation, Tuesday, April 17, 3:55 p.m., Room 404 A-B]


    --  "The poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888 potentiates

         the antitumor activity of temozolomide in the B16F10 syngeneic

         melanoma model: Correlation with pharmacokinetic levels and a

       reduction in poly(ADP-ribose) polymer by ELISA"

        [Oral presentation, Tuesday, April 17, 2:40 p.m., Room 404 A-B]

    --  "ABT-888, a potent PARP inhibitor, enhances the antitumor activities

         by a variety of chemotherapeutic agents in vivo"

        [Poster session, Abstract #1457, Sunday, April 15, 1 p.m. - 5 p.m.,

         Poster section 28, Poster 14, Exhibit Hall]

"Cancer accounts for nearly 25 percent of all deaths in the United States, second only to heart disease," said Stephen Fesik, Ph.D., divisional vice president, Cancer Research, Abbott. "Abbott's Oncology Discovery team is dedicated to finding the next generation of small molecule and biologic therapies that will have an impact on this horrible disease."

"There is particular excitement from the scientific community surrounding Abbott's Bcl-2 family protein inhibitors which block the action of a class of proteins that regulate apoptosis," said Fesik. "This ground-breaking program may prove to be extremely valuable in the fight against cancer. In fact, dozens of researchers from around the world are studying Abbott's Bcl-2 family protein inhibitors and will reveal some of their results at this meeting."

Background on Abbott's Oncology Pipeline

Bcl-2 Family Protein Inhibitors (ABT-263)

Researchers have been interested in the Bcl-2 family of proteins since their role in preventing apoptosis -- the natural process by which damaged or unwanted cells die and are cleared from the body -- was proven more than a decade ago. Discovered by Abbott scientists, ABT-263 restores programmed cell death, a natural mechanism for the elimination of cancerous cells, by inhibiting the function of Bcl-2 proteins.

Bcl-2 proteins play a central role in regulating apoptosis, as well as tumor formation, tumor growth and resistance to treatment. Pioneering work in structural biology at Abbott established how the Bcl-2 family of proteins interact with one another, leading researchers to develop a novel compound that causes cancer cells to self-destruct.

ABT-263 recently entered Phase I clinical trials for lymphomas and solid tumors, including small cell lung cancer. Preclinical data has shown that Abbott's Bcl-2 family protein inhibitors bind to Bcl-2 proteins, restoring cell death to cancerous cells. Additionally, the compounds were found to enhance the effects of chemotherapy and radiation used to treat other types of cancer, such as non-small cell lung cancer.

PARP Inhibitors (ABT-888)

DNA damaging agents remain some of the most successful treatments for cancer. The enzyme Poly(ADP-ribose)polymerase (abbreviated PARP) can help repair DNA damage caused by these agents used to treat cancer and render them ineffective. As PARP activity is often increased in cancer cells, it provides these cells with a survival mechanism.

ABT-888 is an oral PARP-inhibitor developed by Abbott researchers to prevent DNA repair in cancer cells and increase the effectiveness of common cancer therapies such as radiation and alkylating agents.

ABT-888 has entered a Phase 0 trial for patients with refractory solid tumors and lymphoid malignancies, and will enter Phase I trials for melanoma this year. Preclinical data indicates ABT-888 has improved the effectiveness of radiation and many types of chemotherapy in animal models of cancer.

Kinase Inhibitors (ABT-869)

Many oncology researchers are currently developing agents that target kinases, a class of enzymes that are often overly activated in cancer cells. Inhibition of the appropriate kinases can suppress tumor growth by cutting off its blood supply.

Discovered by Abbott scientists, ABT-869 is a multitargeted kinase inhibitor that is in Phase I clinical trials for solid tumors and selected hematologic malignancies such as leukemia. Phase II trials for several tumor types will also begin t his year. Data presented at previous AACR meetings highlighted the antitumor effects of ABT-869 across a broad range of tumor models.

Other Compounds

Abbott scientists remain dedicated to exploring a variety of cutting-edge treatments in the fight against cancer. In addition to Bcl-2 family protein inhibitors, PARP inhibitors and kinase inhibitors, other compounds moving through the development pipeline include ABT-751, an oral, once-daily antimitotic (a class of drugs that inhibit cell division) in ongoing studies for non-small cell lung cancer, and ABT-828, a biologic compound that blocks angiogenesis of cancer cells.

About Abbott Oncology

Abbott Oncology is committed to the discovery and development of innovative cancer treatments that enable patients to live longer and healthier lives. Abbott's oncology research is focused on developing more targeted, less toxic therapies than are currently available to improve the quality of life for some patients living with cancer.

About Abbott

Abbott is a global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals and medical products, including nutritionals, devices and diagnostics. The company employs 65,000 people and markets its products in more than 130 countries.

Abbott's news releases and other information are available on the company's Web site at

CONTACT: media, Catherine Bryan, +1-847-936-6722, financial, Tina Ventura,+1-847-935-9390, both of Abbott

Web site:

Ticker Symbol: (NYSE:ABT)

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


Related medicine technology :

1. Three Studies Suggest Abbotts Humira (adalimumab) May Improve Work Productivity in Patients with Rheumatoid Arthritis
2. Abbott Announces Positive Nine-Month Results From the Worlds First Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent
3. Abbott Announces Continued Positive Results with Xience V Everolimus Eluting Coronary Stent in Spirit Clinical Trials
4. New Analysis of Data Shows Treatment With Abbotts Humira (Adalimumab) Significantly Reduced Disease-Related Hospitalization for Patients with Crohns Disease
5. Abbotts Investigational Treatment ABT-874 Shows Positive Results in Phase II Psoriasis Study
6. Two Abbott Studies Reaffirm Carotid Artery Stenting as a Safe and Effective Treatment to Reduce Risk of Stroke
7. Abbott Announces Positive Six-Month Results From the Worlds First Clinical Trial of a Fully Bioabsorbable Drug-Eluting Coronary Stent
8. Abbotts Xience V Everolimus Eluting Coronary Stent Superior to Taxus Stent in Spirit III U.S. Pivotal Clinical Trial
9. Abbott to Present New Data Across its Vascular Portfolio at the American College of Cardiologys 56th Annual Scientific Session
10. NIEHS Researchers Identify Enzyme Critical in DNA Replication
11. Stanford Researchers Find Brain Pathway of Depression in Rats
Post Your Comments:
(Date:11/30/2015)... FRANCISCO , Nov. 30, 2015 Next ... Designers of Things (DoT ) co-located events covering ... and the Internet of Things, will draw more than ... Jose Convention Center. The events, combined show ... latest technologies. --> ...
(Date:11/30/2015)... Nov. 30, 2015   Royal Philips (NYSE: ... the industry,s first MRI guided user interface and automatic ... patients with MR Conditional implants, such as knee and ... 2015 Radiological Society of North America Annual Meeting (RSNA) ... supports diagnostic confidence of this growing patient population. ScanWise ...
(Date:11/30/2015)... 30, 2015 North America ... to grow at a CAGR of 7.6% from 2015 to 2020. ... USD 135.6 million in 2014, and is expected to grow at ... According to the new Market Research Report "North America Cardiac Output ... User (Hospitals, ambulatory care, others) - Analysis And Forecast To 2020", ...
Breaking Medicine Technology:
(Date:11/30/2015)... City, NY (PRWEB) , ... December 01, 2015 ... ... honors Dale Jones as a 2015-2016 inductee into its VIP ... leadership in education. NAPW is the nation’s leading networking organization exclusively for professional ...
(Date:11/30/2015)... Md. (PRWEB) , ... November 30, 2015 , ... ... rewarding, but also extremely stressful. At the VA Maryland Health Care System, ... care for veterans patients. “Caregivers have a difficult job. Seventy-four percent report ...
(Date:11/30/2015)... ... November 30, 2015 , ... Stress, anxiety, illness, infection or even a ... possible tumors? , Heather Spader, MD, a new pediatric neurosurgeon at Joe DiMaggio Children’s ... might point to tumors. , “Bad headaches that don’t go away, that ...
(Date:11/30/2015)... ... November 30, 2015 , ... An extensive ... is specialized and only includes chiropractic clinics in the US. , The team ... alternative health practitioner when back pain sets in. When people are experiencing back ...
(Date:11/30/2015)... Los Angeles, CA (PRWEB) , ... November 30, 2015 , ... ... such as grafts, strip harvesting and follicular unit extraction. These techniques and procedures have ... of helping patients suffering from hair loss. While Dr. Parsa Mohebi, M.D. has utilized ...
Breaking Medicine News(10 mins):