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Abbott Announces Continued Positive Results with Xience V,Everolimus Eluting Coronary Stent in Spirit Clinical Trials

adverse cardiac events in patients (4.0 percent XIENCE V treated patients, 8.0 percent TAXUS treated patients, P-superior = 0.004). -- Reducing the number of retreatments in patients due to ischemia, or lack of blood supply (ischemic target lesion revascularization, TLR), (2.4 percent XIENCE V, 5.1 percent TAXUS, P-superior = 0.01). -- Reducing the amount of renarrowing in the vessel within the length of the stent (in-stent binary restenosis), (1.9 percent XIENCE V, 4.9 percent TAXUS, P-superior = 0.02). -- Reducing the amount of renarrowing in the vessel within the length of the stent plus 5 mm beyond the ends of the stent (in-segment restenosis), (4.1 percent XIENCE V, 7.8 percent TAXUS, P-superior = 0.04).

"The combination of long-term safety data from SPIRIT FIRST and superior efficacy data from SPIRIT II and SPIRIT III add to the growing body of evidence supporting the XIENCE V system as an important next-generation technology," said John M. Capek, Ph.D., senior vice president, Abbott Vascular. "We look forward to continuing to expand patient and physician access to the XIENCE V system around the world."

About XIENCE V

XIENCE V was launched in Europe and Asia Pacific in 2006. XIENCE V is currently an investigational device in the United States and Japan. Results from the SPIRIT III trial are intended to support U.S. Food and Drug Administration (FDA) approval of the XIENCE V Stent System and Ministry of Health, Labour and Welfare approval in Japan.

Abbott expects to complete Pre-Market Approval (PMA) submission of the XIENCE V system to the U.S. FDA in the second quarter of 2007.

The XIENCE V system utilizes everolimus, which has been shown to reduce tissue proliferation in coronary vessels following stent implantation, and one of the world's most popular metallic platforms -- the MULTI-LINK VISION Coronary Stent System.

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