( PORTLAND Ore.--(BUSINESS WIRE)--May 1...)AVI BioPharma Reports Positive Pre-Clinical Influenza Data,Health

PORTLAND, Ore.--(BUSINESS WIRE)--May 1, 2007 - AVI BioPharma, Inc. (Nasdaq:AVII) and collaborators presented pre-clinical data demonstrating effectiveness of NEUGENE(R) antisense compounds against seasonal influenza A virus in mice. Thomas G. Voss, Ph.D., assistant professor, Department of Microbiology and Immunology, Tulane University School of Medicine, presented the data in poster form at the 20th International Conference on Antiviral Research on April 30, 2007.

In experiments sponsored by AVI and conducted at Tulane University School of Medicine and the United States Army Medical Research Institute for Infectious Diseases (USAMRIID), mice were pre-treated with antisense phosphorodiamidate morpholino oligomers (PMOs), and then infected with two different strains of influenza A (H3N2 and H1N1). Treated mice showed significantly reduced clinical signs (weight loss) and increased survival compared to control treated and untreated mice. In addition, PMO-treated mice showed significantly reduced viral titer (to below limit of detection) in comparison to untreated mice. Histological examination of the lungs showed that treated mice had reduced pathology when examined for infiltrating cells or alveolar damage.

"These data, in combination with other pre-clinical research, reinforce our belief that NEUGENE antisense compounds are potentially well-suited to treating seasonal influenza A infections," said Patrick L. Iversen, Ph.D., senior vice president of research and development at AVI. "Now that we have demonstrated efficacy against multiple strains of seasonal flu in this model, we intend to evaluate our compounds in additional animal models to test their potential efficacy against the H5N1 subtype of avian flu."

AVI's NEUGENE antisense drug development program against the influenza A virus targets genetic regions of the virus that are highly conserved across six viral subtypes that cause human diseas
'"/>

Page: 1 2 3
Related medicine technology :

1. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
2. Array BioPharma to Present at the C.E Unterbeg, Towbin Emerging Growth Conference
3. DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC
4. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
5. Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory Drugs
6. PDL BioPharma Announces Long-Term Nuvion Data Presented at 2007 Digestive Disease Week
7. Helix BioPharma Corp. Announces Positive Phase II Clinical Results with its Topical Interferon Alpha-2b
8. CeNeRx BioPharma Announces Positive Phase I Results in First Human Trial of Third Generation RIMA Antidepressant
9. Integrated BioPharmas Proprietary Vaccine Technology Achieves Strong Positive Results
10. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
11. Cobalis Reports Phase III Trial Results for PreHistin in Seasonal Allergic Rhinitis