Navigation Links
AM-Pharma Announces Positive Results of a Phase IIa Clinical Trial,with Alkaline Phosphatase in Acute Renal Failure

Results expand potential application of key product in AM-Pharma's pipeline

BUNNIK, The Netherlands, 14 March, 2007. AM-Pharma B.V., the biopharmaceutical company developing novel therapeutics to treat infectious and inflammatory diseases, today announced positive results in patients with Acute Renal Failure. The patients involved were a subgroup of a Phase IIa trial with Alkaline Phosphatase to treat Sepsis.

Plasma creatinine clearance, a marker for renal function, improved by 45% (median) in patients with Acute Renal Failure treated with Alkaline Phosphatase and deteriorated by 25% (median) in patients with Acute Renal Failure treated with placebo, with p values of < 0.05.


In addition, the level of glutathione-S-transferase-A1, a marker for kidney damage, decreased by 70% (median) in AP treated patients, compared to a 200% (median) increase in placebo treated patients, with p values again of < 0.05.


Fifteen patients (10 active, 5 placebo) with Acute Renal Failure were treated for 24 hours as part of a double-blind, randomized, placebo-controlled Phase IIa study in 36 Sepsis patients. The study took place in the Department of Intensive Care Medicine at the Radboud University Medical Centre, Nijmegen, The Netherlands.


Bart Wuurman, CEO of AM-Pharma commented on the positive results, saying: "We are very excited by the results in this Acute Renal Failure subgroup. It shows statistically significant and clinically relevant improvements in a condition that is very difficult to treat, has a high mortality rate and is associated with high costs through long term dialysis treatment. We now plan to explore the use of Alkaline Phosphatase in Acute Renal Failure in a separate study."


- ENDS -

Notes to editors:

About AM-Pharma www.am-pharma.com <http://www.am-pharma.com/> AM-Pharma is a biopharmaceutical company focused on the preclinical and clinical development of novel compounds in the field of severe infectious diseases and inflammatory diseases.

AM-Pharma is currently conducting Phase II clinical trials on two products:

* Alkaline Phosphatase for Sepsis, Acute Renal Failure and Ulcerative Colitis. * Anti-microbial Peptide hLF1-11,for the prevention of infections in Hemopoietic Stem Cell Transplant patients.

AM Pharma is based in Bunnik, The Netherlands with a staff of 20. The company is financed by, amongst others, Forbion Capital Partners and Inventages Venture Capital. Once product safety and efficacy have been established, AM-Pharma will look for world-wide development and marketing partners for its products.

About Acute Renal Failure Hospital-acquired Acute Renal Failure occurs in as many as 4% of hospital admissions and 20% of critical care admissions. The growing incidence of hospital-acquired Acute Renal Failure is due to an increasingly aging population, an increased probability of exposure to nephrotoxic drugs in hospitals and an increasing number of surgical interventions. Depending on the severity of renal failure, mortality rates can range from 7% to as high as 80%. Of patients that do survive, between 20% and 60 % require ongoing dialysis treatment.

*** Should you be interested in downloading a white paper on AM Pharma's Alkaline Phosphatase Phase IIa trial and its application in the treatment of Acute Renal Failure, please click here - www.am-pharma.com <http://www.am-pharma.com/> or contact Justine Lamond on +44 (0)20 7268 3242 or j.lamond@northbankcommunications.com


For further information, please contact

Northbank Communica tions

Justine Lamond

Tel: +44 (0)20 7268 3242

j.lamond@northbankcommunications.com


AM Pharma

CEO Bart Wuurman

Tel: +31 (0)30 2289222

www.am-pharma.com

Justine Lamond Account Manager ---------------------------------------------

Direct line: +44 (0)20 7268 3242 Mobile: +44 (0)7919 828314 Main tel: +44 (0)20 7268 3002 Fax: +44 (0)20 7268 3102

www.northbankcommunications.com

Please note our new address details are:

85 Tottenham Court Road,

London, W1T 4DU UK




'"/>




Related medicine technology :

1. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
2. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
3. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
6. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... DUBLIN , Dec 2, 2016 Research ... Pipeline Database" newsletter to their offering. ... , , ... La Merie Publishing,s proprietary R&D Drug Pipeline Database provides 24/7 online ... therapeutic drugs on the market and on investigational drug candidates in ...
(Date:12/2/2016)... the largest share in the ECG Cables And ECG Leadwires ... remote monitoring ECG devices. On the other hand, the ... the highest growth rate during the forecast period. ... Company (U.S.), Medtronic plc ( Ireland ), Koninklijke ... Medical International Limited ( China ), held major ...
(Date:12/2/2016)... Quantum Radiology,s Mobile Breast Center (QR MBC) brings cutting-edge ... at the workplace, thereby maximizing convenience and compliance.  QR ... and SunTrust Bank, and community health groups to provide ... "I think it,s a great service for ... a mammogram without taking a large amount of time ...
Breaking Medicine Technology:
(Date:12/2/2016)... Dothan, AL (PRWEB) , ... December 02, 2016 ... ... leaders from across the Dothan-Wiregrass Area in Alabama are expected to attend the ... Mike Schmitz, will help provide scholarship funds for area students and operating support ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... The annual ... Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare beneficiaries who ... C) or prescription drug plan (Part D) need to make changes during this period ...
(Date:12/2/2016)... Hills, CA (PRWEB) , ... December 02, 2016 ... ... reconstructive surgeon in Beverly Hills, California, will be included in the 2016 “Guide ... given to exceptional professionals based on the amalgamation of their education, experience, and ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... the Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, offering local frontline ... field of pain management. , The demand for supplemental training related to ...
(Date:12/2/2016)... Texas (PRWEB) , ... December 02, 2016 , ... Yisrayl ... that delves into how this current generation fits into Bible Prophecy. Yisrayl says this ... various facts pointing to this conclusion, showing how the details line up exactly with ...
Breaking Medicine News(10 mins):