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AM-Pharma Announces Positive Results of Phase IIa Clinical Trial,with Alkaline Phosphatase For Ulcerative Colitis

that this first AP study for ulcerative colitis revealed our treatment to be clinically active, despite the short seven day treatment period and the severity of the patients' disease. These results are very promising for the future development of AP for ulcerative colitis, where we plan to administer AP treatment for longer periods. Also importantly, results from this trial revealed that the treatment is very well tolerated. This is potentially good news for ulcerative colitis sufferers, who are looking for safe and effective treatment options."

AM-Pharma will continue to study the oral use of AP for ulcerative colitis in a further Phase II clinical study. Once safety and efficacy have been confirmed in a larger group of patients, AM-Pharma intends to license the product to a partner who will take on the late-stage development and worldwide commercialisation of AP.

Notes to editors:

About AM-Pharma www.am-pharma.com AM-Pharma is a biopharmaceutical company focused on the preclinical and clinical development of novel compounds in the field of severe infectious diseases and inflammatory diseases. All its products are based on endogenous molecules which have been optimised to combat disease.

AM-Pharma is currently conducting Phase II clinical trials for two products; Alkaline Phosphatase for sepsis, acute renal failure and ulcerative colitis; and Anti-microbial Peptide hLF1-11 for the prevention of infections in hemopoietic stem cell transplant patients.

AM-Pharma is based in Bunnik, The Netherlands with a staff of 20. The company is financed by, amongst others, Forbion Capital Partners, Inventages Venture Capital and Theratase plc. Once product safety and efficacy have been established, AM-Pharma will look for world-wide development and marketing partners for its products.

About Alkaline Phosphatase (AP)

The endogenous enzyme Alkaline Phosphatase is expr
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