Navigation Links
AGI Dermatics Presents Comparative Data That Indicates OCTN-1 Skin,Cells Have the Ability to Recognize, Transport and Utilize,L-ergothioneine (EGT) As A Protector Against Oxidative Damage

Clinical Poster Presented at Society for Investigative Dermatology

FREEPORT, N.Y., May 16, 2007 /PRNewswire/ -- AGI Dermatics recently announced new comparative clinical data that indicates that OCTN-1 skin cells have the ability to recognize, transport and utilize L-ergothioneine (EGT) as a protector against oxidative damage, and importantly, that (EGT) acts as a more powerful and efficient antioxidant than idebenone, scavenging reactive oxygen species and reducing UV-induced hydrogen peroxide (H2O2). The data was presented at the 68th Annual Meeting of the Society for Investigative Dermatology, May 9 - 12, in Los Angeles, CA.

"We are very excited that this clinical work demonstrates that OCTN-1 plays a vital role in the active accumulation and utilization of EGT for the treatment of photodamaged skin," said Daniel Yarosh, PhD, President, AGI Dermatics. "This data confirms that L-ergothioneine is a natural part of the skin's antioxidant system."

EGT is an exclusive and maximized natural amino acid that has been used in topical applications. The cellular receptor and transporter for EGT, OCTN-1 has recently been identified and is responsible for the intracellular accumulation of this naturally occurring antioxidant. However, there have been questions of the role of EGT and its receptor/transport, OCTN-1.

To examine this, the mRNA expression in cultured normal human epidermal keratinocytes (NHEK) and normal human dermal fibroblasts (NHDF) was analyzed. Results indicate OCTN-1 mRNA was detectable equally in both NHEK and NHDF with quantitative measurements by real-time PCR. To further investigate any differences in production of OCTN-1 and to assure production of OCTN-1 in both NHEK and NHDF, the study also looked at the transcription of the OCTN-1 mRNA into OCTN-1 protein. Results indicate OCTN-1 protein isoforms were more abundant in NHDF than NHEK, though still detectable in NHEK, as shown by western, blot analysis.

The study also examined whether this new patented form of EGT further exhibited properties of a super-antioxidant, and therefore EGT's beneficial role in the treatment of photodamaged skin. Study results show that NHDF treated with EGT had significant lower levels of hydroxyl radicals over a one-hour period than those treated with idebenone, a synthesized form of CoQ10 which has also been thought to exhibit exceptional antioxidant properties.

AGI Dermatics is the developer of Remergent(R), a doctor-dispensed skincare line based on the science of DNA repair. AGI manufactures Remergent(R) Clarifying Concentrate, a formula designed to treat hyperpigmentation, which contains EGT as a key ingredient. EGT has also been shown to be clinically effective in enhancing skin brightness.

About AGI Dermatics

AGI Dermatics is the bio-pharmaceutical laboratory that has led the research of DNA repair of the skin for more than 20 years. Founded by Daniel B. Yarosh, PhD, AGI Dermatics specializes in skin photobiology, dedicating research and development to DNA repair, solar impact on the immune system, and cell-signaling in skin. The company's application of groundbreaking active ingredients and meticulously engineered liposome delivery systems is validated in controlled clinical studies and published in dozens of peer-reviewed scientific and medical journals.

CONTACT: Courtney McGeever for AGI Dermatics, +1-212-317-1462

Web site:

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


Related medicine technology :

1. AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1 and TNF-alpha in UV Irradiated Skin Cells
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
(Date:12/1/2015)... and TELTOW, Germany , ... Instruments (SMI) , a leading global manufacturer of eye ... LLC has included SMI remote eye trackers as ... help healthcare providers assess concussions, eye sight, and medical ... RED -oem technology is part of SMI,s mass-market-ready eye ...
(Date:12/1/2015)... , December 1, 2015 ... Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), among ... has acquired Elekta,s Leksell Gamma Knife® Icon™, the ... brain. --> --> ... or traditional frame-based treatments, Leksell Gamma Knife Icon ...
(Date:12/1/2015)... 01, 2015 ... "Drug Delivery Technology Market 2015 - Forecast to ... ) has announced the addition of ... Forecast to 2020" report to their offering. ... ) has announced the addition of the ...
Breaking Medicine Technology:
(Date:12/1/2015)... TX (PRWEB) , ... December 01, 2015 , ... Dr. ... of Vitenas Cosmetic Surgery, has been named by MedEsthetics magazine as the Best Single ... of the best among the many elite aesthetic physicians honored by the industry publication. ...
(Date:12/1/2015)... ... 2015 , ... December 1, 2015 -- InstantLabs is adding ... product line of food safety and seafood fraud prevention tools. , The new ... InstantLabs to offer fast, reliable species identification for the four most popular salmon. ...
(Date:12/1/2015)... ... 2015 , ... It’s official: Tattoo taboo is a thing of the past. ... Millennials (a whopping one in three aged 18 to 25 is inked). As tattoos ... their ink. In fact, RealSelf , the world’s largest community for learning and ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... of adjunctive imaging is the focus of numerous abstracts accepted for presentation here, ... 4, 2015. Nine abstracts highlight the use of Volpara Solutions’ quantitative breast ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... , Visage Imaging Inc. (“Visage”), a wholly owned subsidiary of Pro Medicus Ltd. ... results enhancements at the Radiological Society of North America (RSNA) 2015 annual meeting ...
Breaking Medicine News(10 mins):