Navigation Links
AGI Dermatics Presents Comparative Data That Indicates OCTN-1 Skin,Cells Have the Ability to Recognize, Transport and Utilize,L-ergothioneine (EGT) As A Protector Against Oxidative Damage

Clinical Poster Presented at Society for Investigative Dermatology

FREEPORT, N.Y., May 16, 2007 /PRNewswire/ -- AGI Dermatics recently announced new comparative clinical data that indicates that OCTN-1 skin cells have the ability to recognize, transport and utilize L-ergothioneine (EGT) as a protector against oxidative damage, and importantly, that (EGT) acts as a more powerful and efficient antioxidant than idebenone, scavenging reactive oxygen species and reducing UV-induced hydrogen peroxide (H2O2). The data was presented at the 68th Annual Meeting of the Society for Investigative Dermatology, May 9 - 12, in Los Angeles, CA.

"We are very excited that this clinical work demonstrates that OCTN-1 plays a vital role in the active accumulation and utilization of EGT for the treatment of photodamaged skin," said Daniel Yarosh, PhD, President, AGI Dermatics. "This data confirms that L-ergothioneine is a natural part of the skin's antioxidant system."

EGT is an exclusive and maximized natural amino acid that has been used in topical applications. The cellular receptor and transporter for EGT, OCTN-1 has recently been identified and is responsible for the intracellular accumulation of this naturally occurring antioxidant. However, there have been questions of the role of EGT and its receptor/transport, OCTN-1.

To examine this, the mRNA expression in cultured normal human epidermal keratinocytes (NHEK) and normal human dermal fibroblasts (NHDF) was analyzed. Results indicate OCTN-1 mRNA was detectable equally in both NHEK and NHDF with quantitative measurements by real-time PCR. To further investigate any differences in production of OCTN-1 and to assure production of OCTN-1 in both NHEK and NHDF, the study also looked at the transcription of the OCTN-1 mRNA into OCTN-1 protein. Results indicate OCTN-1 protein isoforms were more abundant in NHDF than NHEK, though still detectable in NHEK, as shown
'"/>




Page: 1 2

Related medicine technology :

1. AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1 and TNF-alpha in UV Irradiated Skin Cells
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
(Date:7/11/2014)... 11, 2014 Research and Markets ... Chinese Medical X-ray Film Industry Report 2014" report ... Global And Chinese Medical X-Ray Film ... on the current state of the Global medical X-ray ... The report provides a basic overview of the ...
(Date:7/11/2014)...  Kindred Hospital Houston Northwest, with Wound Care ... its new outpatient wound healing center.  The wound ... chronic, hard to heal wounds. Chronic wounds include ... lower leg wounds related to blood flow issues, ... injury wounds which are complex and demonstrate delayed ...
(Date:7/11/2014)... , July 11, 2014 According ... Research "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, and ... Trends and Forecast, 2013-2019" the global endoscopy devices market ... is expected to grow at a CAGR of 6.8% ... of USD 36.9 billion in 2019. Browse ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
(Date:7/13/2014)... WA (PRWEB) July 13, 2014 According to ... this is a step by step guide on what to ... easily and quickly. Vkool writes in its review that ... foods to eat to revitalize their kidney health. Vkool also ... can help people reverse their damaged kidney functions naturally. The ...
(Date:7/13/2014)... A Xarelto lawsuit webpage has been launched ... with the most current information regarding serious internal bleeding ... as well as the growing number of Xarelto ... The law firm is now offering free legal evaluations ... bleeding and related complications while using Xarelto, including:, ...
(Date:7/13/2014)... ECS is being founded by ... of a special needs child, I have become keenly ... for contemporary special education resources and evidence-based instruction. Emerald ... and families in the Seattle metro area that are ... education. We welcome the opportunity to serve our community ...
(Date:7/13/2014)... Ann Arbor, MI (PRWEB) July 13, 2014 ... online learning program he has just launched at http://www.HealthYourself101.com ... management of visceral obesity. , Power has set out ... and its ill effects that’s actually – dare we say ... , “The program,” says Power, “aims to engage the remote ...
(Date:7/13/2014)... Wa (PRWEB) July 13, 2014 According ... by Vkool.com, this is a comprehensive guide that features ... deal with KP (keratosis pilaris). This guide ... 1: What Is Keratosis Pilaris? ,     Chapter 2: ... I Know If I Have KP? ,     Chapter ...
Breaking Medicine News(10 mins):Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 2Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 4Health News:New Private School, Emerald City School, Founded in Downtown Seattle Now Accepting 1st to 6th Grade Students Who Learn Differently 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 3
... (Nasdaq: MLAB ) today reported record sales and net income ... -- Annual revenue increases 13% to a new record -- ... Annual net income increases 16% to a new record -- ... Fourth quarter operating income increases 7% to a new record, ...
... Expertise for Partners ... the Google Health Platform, PORTLAND, Ore., May 19 ... company, announced,collaboration today with Google as a development and consulting ... public at an,event at Google,s headquarters today; the product allows ...
... can now not only feel the spicy kick of a ... thanks to researchers at Baylor College of Medicine in Houston. ... Theodore G. Wensel, professor of biochemistry and molecular biology at ... that allows you to sense the heat of a hot ...
... Only half of patients had their therapy changed as ... -- Diabetics with high blood pressure have only a ... as needed or offer other treatment, a new study ... diabetes is very important, because elevated pressure can lead ...
... the antidepressant citalopram before beginning treatment for head and ... to results of a pilot study published in the ... one of the JAMA/Archives journals. , Treatment for head ... authors write as background information in the article. Psychiatric ...
... Case Medical Center (UHCMC) finds that elderly patients ... are not treated as aggressively as patients between 65 ... that if patients over 75 years old are treated ... better survival rates. The findings appear in the April ...
Cached Medicine News:Health News:Mesa Labs Reports Record Year End Sales and Earnings 2Health News:Mesa Labs Reports Record Year End Sales and Earnings 3Health News:Mesa Labs Reports Record Year End Sales and Earnings 4Health News:Mesa Labs Reports Record Year End Sales and Earnings 5Health News:Mesa Labs Reports Record Year End Sales and Earnings 6Health News:Mount Tabor Collaborates with Google Health 2Health News:Some like it hot! Structure of receptor for hot chili pepper and pain revealed 2Health News:Many Diabetics Don't Get Necessary Blood Pressure Treatment 2Health News:Many Diabetics Don't Get Necessary Blood Pressure Treatment 3Health News:Medication may prevent depression in patients with head and neck cancer 2Health News:Study: Patients 75 years and older with brain tumors may benefit from more aggressive treatment 2
... The Genesis II* Total Knee System ... Now, far more is possible with less ... options, while fully addressing both clinical and ... components meet these design goals, giving surgeons ...
Cruciate retaining, posterior stabilized and constrained components....
... The TC-PLUS Solution tricompartmental total knee prosthesis ... knee arthroplasty. State-of-the-art design and manufacturing technologies ... optimum biomechanical function as well as a ... tibial insert to keep wear to a ...
...
Medicine Products: