Navigation Links
AGI Dermatics Presents Comparative Data That Indicates OCTN-1 Skin,Cells Have the Ability to Recognize, Transport and Utilize,L-ergothioneine (EGT) As A Protector Against Oxidative Damage

Clinical Poster Presented at Society for Investigative Dermatology

FREEPORT, N.Y., May 16, 2007 /PRNewswire/ -- AGI Dermatics recently announced new comparative clinical data that indicates that OCTN-1 skin cells have the ability to recognize, transport and utilize L-ergothioneine (EGT) as a protector against oxidative damage, and importantly, that (EGT) acts as a more powerful and efficient antioxidant than idebenone, scavenging reactive oxygen species and reducing UV-induced hydrogen peroxide (H2O2). The data was presented at the 68th Annual Meeting of the Society for Investigative Dermatology, May 9 - 12, in Los Angeles, CA.

"We are very excited that this clinical work demonstrates that OCTN-1 plays a vital role in the active accumulation and utilization of EGT for the treatment of photodamaged skin," said Daniel Yarosh, PhD, President, AGI Dermatics. "This data confirms that L-ergothioneine is a natural part of the skin's antioxidant system."

EGT is an exclusive and maximized natural amino acid that has been used in topical applications. The cellular receptor and transporter for EGT, OCTN-1 has recently been identified and is responsible for the intracellular accumulation of this naturally occurring antioxidant. However, there have been questions of the role of EGT and its receptor/transport, OCTN-1.

To examine this, the mRNA expression in cultured normal human epidermal keratinocytes (NHEK) and normal human dermal fibroblasts (NHDF) was analyzed. Results indicate OCTN-1 mRNA was detectable equally in both NHEK and NHDF with quantitative measurements by real-time PCR. To further investigate any differences in production of OCTN-1 and to assure production of OCTN-1 in both NHEK and NHDF, the study also looked at the transcription of the OCTN-1 mRNA into OCTN-1 protein. Results indicate OCTN-1 protein isoforms were more abundant in NHDF than NHEK, though still detectable in NHEK, as shown
'"/>




Page: 1 2

Related medicine technology :

1. AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1 and TNF-alpha in UV Irradiated Skin Cells
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
(Date:1/23/2015)... More than a third of reproductive-aged women enrolled in Medicaid, ... filled a prescription for an opioid pain medication each year ... and Mortality Weekly Report (MMWR). Opioids are ... severe pain.  They are also found in some prescription cough ...
(Date:1/23/2015)... all-time hits leader, is the new spokesperson for the topical ... announced. "Pete,s a Hall of Famer in our ... with Myoflex," said Ducere Pharma Chief Executive Officer Chris ... across all generations. The passion and intensity that Pete brought ...
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has ... increase market share and grab a foothold in the hydroponic, ... production capabilities and a presence in the sector, and recently ... the growth of hemp and medical marijuana, iMD is committing ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Pete Rose bets on Myoflex to relieve aches and pains 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue ... means to “Live Fearless.” , The “Faces of ... stories about how they or someone they know has faced ... in the moment. By telling these types of stories through ...
(Date:1/22/2015)... A new white paper by The Beryl ... the long-term care environment as well as provides recommendations ... paper, “The Power of Person-Centeredness in Long-Term Care: A ... the patient, resident and family experience in long-term care ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... 23, 2015 Recently, Weddingshe.com has added many ... has announced its highest annual revenues in the past three ... popular glamorous wedding dresses. , According to the sales manager ... dress promotions for them in 2015. This point can be ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... have opened up a whole new approach to the ... thanks to a completely new and unexpected finding. ... Santos, have published their research this week in leading ... of how transcriptional repression complexes work. Their work, which ...
... published in the January issue of Health Affairs ... prevent the costly chronic disease that affects nearly 26 ... Public Health (RSPH) systematically reviewed the published literature and ... Prevention Program (DPP) trial in real-world settings. Published in ...
... The January/February issue of Annals takes an up-close ... in a single individual, a phenomenon that is growing at ... It is estimated by the year 2020, 25 percent of ... and costs for managing these conditions will reach $1.07 trillion. ...
... may prove to be a better way for hospital emergency ... to waiting for outdated government flu case reports. A report ... departments, studied by a team of researchers at Johns Hopkins ... 9 issue of Clinical Infectious Diseases . The ...
... Salamon HealthDay Reporter , MONDAY, Jan. 9 (HealthDay ... patients as three types of traditional acupuncture, a new study ... groups at nine Chinese hospitals -- one sham acupuncture group ... researchers, including Dr. Fan-rong Liang at Chengdu University in China, ...
... , MONDAY, Jan. 9 (HealthDay News) -- High ... in the number of people with private health insurance limited ... 3.9 percent in 2010, according to a new study. ... care or seek less expensive treatment, said researchers at the ...
Cached Medicine News:Health News:Unexpected discovery opens up new opportunities for targeting cancer 2Health News:Diabetes study shines spotlight on lifestyle interventions 2Health News:Diabetes study shines spotlight on lifestyle interventions 3Health News:January/February 2012 Annals of Family Medicine 2Health News:January/February 2012 Annals of Family Medicine 3Health News:January/February 2012 Annals of Family Medicine 4Health News:January/February 2012 Annals of Family Medicine 5Health News:January/February 2012 Annals of Family Medicine 6Health News:January/February 2012 Annals of Family Medicine 7Health News:January/February 2012 Annals of Family Medicine 8Health News:January/February 2012 Annals of Family Medicine 9Health News:Hopkins researchers find 'Google Flu Trends' a powerful early warning system for emergency departments 2Health News:Power of Acupuncture to Ease Migraines Questioned in Study 2Health News:Power of Acupuncture to Ease Migraines Questioned in Study 3Health News:Growth in U.S. Health Spending Stayed Slow in 2010 2Health News:Growth in U.S. Health Spending Stayed Slow in 2010 3
... A breakthrough in non-invasive cardiac diagnosis, ... is the first and only stress test ... microvolt level. The pre-test lead check provides ... the WAVESTAR ECG filter that dynamically filters ...
... w/ Remote/Controller. Includes Full Range of ... Multiple 20/20 slides. Polarized and ... you to customize your slide choices. ... Long Life. Variety of mounting options. ...
... System II which includes both the Octopus4 ... The Starfish2 heart positioner provides excellent access ... The new Octopus System II (Octopus4 ... of use and performance that make it ...
... Introducing Guidant's fourth generation access device ... to lift the heart. The XPOSE 4 ... heart during off-pump bypass surgery and to ... maintaining hemodynamics. Designed for both apical and ...
Medicine Products: