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AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1,Encapsulated in Liposomes, Reduces MMP-1 and TNF-alpha in UV,Irradiated Skin Cells

diation, cells were treated with 1ug/mL OGG1 liposomes for up to 48 hours. The study then looked at the results of "repair by damaging" the DNA. The treatment of ssUV stimulated NHEK results in an increased TNF-alpha mRNA expression after 24 hours and TNF secretion after 48 hours. Both ssUV-induced TNF- mRNA and secreted protein were reduced by 50% following OGG1 liposome treatment.

In conclusion, these results indicate that treatment of dermal fibroblasts and epidermal keratinocytes with OGG1 liposomes enhance DNA repair, leads to a reduction in the expression and/or secretion of stress responses proteins such as ssUV-induced MMP-1 and ssUV-induced TNF-a mRNA.

AGI Dermatics is the developer of Remergent, a doctor-dispensed skincare line based on the science of DNA repair. Remergent DNA Repair Formula and Antioxidant Refoliator both contain Roxomes, liposomes encapsulating OGG1, which protect the cells genetic material from ROS.

About AGI Dermatics

AGI Dermatics is the bio-pharmaceutical laboratory that has led research of DNA repair of the skin for more than 20 years. Founded by Daniel B. Yarosh, PhD, AGI Dermatics specializes in skin photobiology, dedicating research and development to DNA repair, solar impact on the immune system, and cell- signaling in skin. The company's application of groundbreaking active ingredients and meticulously engineered liposome delivery systems is validated in controlled clinical studies and published in dozens of peer-reviewed scientific and medical journals. www.agiderm.com

CONTACT: Courtney McGeever, +1-212-317-1462, for AGI Dermatics

Web site: http://www.agiderm.com/

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