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AEterna Zentaris Reports Positive Results with Cetrorelix in BPH,for Japanese Phase 2a Trial

than 50% of men 60 years and over, with approximately 56 million cases in the U.S., Europe and Japan. In 2004, BPH treatment represented a market size of over US$4 billion. Contrary to most of the present treatments for BPH, cetrorelix is not associated with side-effects such as erectile dysfunction, loss of libido and chemical castration. According to Decision Resource, cetrorelix is currently the most advanced LHRH antagonist in development for the treatment of BPH.

About Cetrorelix

Cetrorelix is part of AEterna Zentaris' LHRH antagonist therapeutic approach. This peptide-based active substance was developed by the Company in cooperation with Nobel-Prize winner Professor Andrew Schally of the U.S. Veterans Administration in Miami and the University of Miami.

Cetrorelix is marketed under the brand name Cetrotide(R), the first LHRH antagonist approved for therapeutic use as part of in vitro fertilization programs (controlled ovulation stimulation/assisted reproductive technologies) in Europe, the USA and Japan. It was launched on the market through Merck Serono in the USA, Europe and in several other countries, as well as in Japan through Shionogi.

AEterna Zentaris is currently conducting a large Phase 3 program with cetrorelix in BPH while the Company's partner, Solvay is sponsoring a pivotal clinical program for endometriosis with this same compound.

About AEterna Zentaris Inc.

AEterna Zentaris Inc. is a late-stage global biopharmaceutical company focused on endocrine therapy and oncology, with proven expertise in drug discovery, development and commercialization.

News releases and additional information are available at www.aeternazentaris.com.

Forward-Looking Statements

This press release contains forward-looking statements made pursuant to the safe harbor provisions of the U.S. Securities Litigation Reform Act of 1995. Forward-looking s
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