Navigation Links
AEterna Zentaris Reports Positive Results with Cetrorelix in BPH,for Japanese Phase 2a Trial

p>

The completed Phase 2a trial with cetrorelix in BPH was designed to evaluate primarily pharmacokinetics and safety (systemic and local tolerability) in Japanese subjects, whereas evaluation of efficacy was only exploratory.

In this multicenter, placebo-controlled and randomized trial, the sustained release formulation cetrorelix pamoate was administered intramuscularly as single or multiple dosing schedules. A total of 50 patients were included in 5 dosing groups corresponding to single administration of 30 mg, 60 mg or 90 mg cetrorelix and multiple administration of 60 mg and 90 mg, 3 times 8 weeks apart. The observation period was up to 32 weeks in the multiple administration dosing groups.

Results

The pharmacokinetic data generated with Japanese patients showed that the bioavailability of cetrorelix after intramuscular cetrorelix pamoate injection is similar to that observed in non-Japanese patients. Similarly, the Japanese patients responded to cetrorelix with a transient reduction of testosterone concentration in blood, which did not reach or remain at the castration level.

Intramuscular injection of cetrorelix pamoate was safe and well tolerated at all dosages tested, both locally and systemically. None of the dosage regimens tested caused a suppression of PSA levels which is important considering that a treatment-related suppression would prevent the use of this marker for the routine monitoring of BPH patients for the potential development of prostate cancer.

The sizes per dosage group were too small to evaluate efficacy trends for statistical significance.

About Benign Prostatic Hyperplasia

BPH is characterized by an abnormal benign growth of the prostatic tissues caused by testosterone. Symptoms linked to BPH include pain while urinating and frequent urges to urinate during the night and sometimes, kidney problems. In some cases, if left untreated, BPH may develop into prostate cancer. BPH affects more
'"/>




Page: 1 2 3 4

Related medicine technology :

1. AEterna Zentaris Partner Keryx Presents Phase 1 and Phase 2 Results for Anti-Cancer Compound Perifosine at ASCO Meeting
2. AEterna Zentaris Partner, Spectrum, Discloses Detailed Phase 2 Data for Ozarelix, in BPH at Annual AUA Meeting
3. AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist JMR-132 at the AACR Annual Meeting in Los Angeles
4. AEterna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
5. AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles
6. terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
7. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
8. Cobalis Reports Phase III Trial Results for PreHistin in Seasonal Allergic Rhinitis
9. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
10. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
11. Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
Post Your Comments:
(Date:5/17/2013)... May 17, 2013   Shareholder rights attorneys  at ... Pharmaceutical, Inc. (NASDAQGS: AVEO) securities has filed a complaint ... Massachusetts .  The complaint alleges that ... Exchange Act of 1934 (the "Exchange Act") between January ... (Logo: http://photos.prnewswire.com/prnh/20130103/MM36754LOGO ) ...
(Date:5/17/2013)... BOSTON , May 17, 2013  TechAtlas ... update for their competitive landscape map for the ... highlights over 90 international companies with drugs and ... addressing CKD and its sequelae. ... include: , hypertension - renal denervation ...
(Date:5/17/2013)... Conn. , May 17, 2013  Boehringer ... in respiratory disease at the American Thoracic Society ... PA , May 17 – 22. ... product approved for the treatment of chronic obstructive ... powder)], as well as investigational compounds for asthma, ...
Breaking Medicine Technology:Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 3Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 4Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 5Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 6Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 7Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 8
... According to the American Diabetes Association, total costs of ... estimated at $174 billion.  Millions of Americans have been ... unaware that they are at risk or in fact ... use pills to manage their diabetes and these medications ...
... LOUISVILLE, Colo., Nov. 1, 2010 Inovonics ( http://www.inovonics.com ... networks for commercial and life safety applications, today ... a wireless sensor solution designed specifically to meet ... on trusted motion-sensing technology, the EN1240 offers a ...
Cached Medicine Technology:Stater Bros. Super Rx Pharmacy Offers FREE Diabetic Medications 2Inovonics Delivers Passive Wireless Sensor for Monitoring Senior Care Resident Activity 2Inovonics Delivers Passive Wireless Sensor for Monitoring Senior Care Resident Activity 3Inovonics Delivers Passive Wireless Sensor for Monitoring Senior Care Resident Activity 4
(Date:5/19/2013)... Argentina: Yoga classes ( clases de Yoga ) will ... Sivananda Yoga Vedanta Center. The center is located ... are 90 minutes and are offered all week long. ... environment, allowing visitors to enjoy the benefits of Yoga, ... , The Yoga classes follow the following principles: , ...
(Date:5/19/2013)... 2013 The Da Vinci robot lawyers ... in the nation’s first trial involving a Da Vinci ... State Superior Court, was filed by the widow of ... complications in a robot-assisted prostate removal, according to a ... robotic surgery lawsuit alleges those complication’s hastened his ...
(Date:5/18/2013)... FL (May 19, 2013) Each year, the ... their outstanding contributions and achievements in gastroenterology through ... of many distinguished and talented individuals who work ... gastroenterology. Today, we are pleased to announce the ... by their colleagues for their tremendous contributions to ...
(Date:5/18/2013)... Thompson HealthDay Reporter , , FRIDAY, May 17 ... the latest edition of what is considered the "bible" ... many changes continues. "This is unprecedented, the amount ... Lieberman, president-elect of the American Psychiatric Association (APA). "It,s ... it is. You have to evaluate it and then ...
(Date:5/18/2013)... (May 18, 2013) There are significant cost ... used to diagnose or treat gastrointestinal problems, according ... , A study by New York Presbyterian ... objective testing may substantially reduce the cost and ... GERD is believed to affect nearly 25 percent ...
Breaking Medicine News(10 mins):Health News:Clases de Yoga in Buenos Aires, Argentina (Yoga Classes) Now Offered by Sivananda Yoga Vedanta Center 2Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 2Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 3Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 4Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 2Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 3Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 4Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 5Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 2Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 3Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 4Health News:New research identifies practice changes to improve value and quality of GI procedures 2
... The US is entering a healthcare crisis, many activists are ... the developed world,// it has been assessed. Around 46 million ... they cannot afford it. ,Drug prices, health insurance, ... people to afford, while insurance and drug company profits continue ...
... personnel will guard the Lok Nayak Jai Prakash (LNGP) ... by relatives of patients.// ,"The existing private ... removed with immediate effect. Some 70 home guards along ... now on," Delhi Health Secretary D.S. Negi told IANS. ...
... number of male babies born in the U.S. is dropping. And ... changing demographic pattern//, says a new study. ,Researchers have ... the last three decades. The decline is equivalent to 135,000 fewer ... the decline is confined to whites only. ,In ...
... - just 798 girls per 1,000 males in the 0-6 ... the Art of Living Foundation//, to tackle the practice of ... Sneh Sanjivni Yatra - by the Foundation in collaboration with ... NGOs Thursday concluded a statewide campaign to make people aware ...
... of couples of childbearing age struggle with the heartache of ... Cornell// researchers' identification of a mutation in a gene that ... time that a dominant mutation that leads specifically to infertility ... can now look for similar mutations in the DNA of ...
... do a good job of aggressively treating the early ... confirm// the diagnosis. The study involved 467 hospitals spread ... a concern that patients may be treated less aggressively ... tests are able to confirm the diagnosis,” said Chadwick ...
Cached Medicine News:Health News:US Confronted by a Major Healthcare Crisis, Say Critics 2Health News:Male Child Birth Dropping in US and Japan 2Health News:Discovery in Male Mice Gives Hope in Providing Clues to Find Infertility in Men 2Health News:Discovery in Male Mice Gives Hope in Providing Clues to Find Infertility in Men 3Health News:Doctors Treat Early Heart Attacks Before Labs Could Confirmation It 2Health News:Doctors Treat Early Heart Attacks Before Labs Could Confirmation It 3
... A necessary addition to ... the Reichert Trial Frame ... and smooth controls for ... robust design, high-quality materials, ...
... Master is designed and constructed ... service and give the professional ... procedures. It embodies the characteristics ... most, including accuracy, speed, ease, ...
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... is provided by a cool-running, energy efficient ... what you need to see without affecting ... all they are maintenance free so you'll ... Every Phoroptor comes with a limited lifetime ...
Medicine Products: