Navigation Links
AEterna Zentaris Partner Keryx Presents Phase 1 and Phase 2 Results,for Anti-Cancer Compound Perifosine at ASCO Meeting

--------------------- Weekly 900 mg or less Weekly 1200 mg or 1500 mg ------------------------------------------------------------------------- Loading Dose 900 mg or less Loading Dose 1200 mg or more ------------------------------------------------------------------------- Daily Dose 100 mg or less Daily Dose 150 mg or more -------------------------------------------------------------------------

The dose schedules in the Phase 1 trials were weekly 100-800 mg or loading dose (LD) 300-1800 mg on Day 1 followed by 50-150 mg daily for Days 2-21 every 28 days or LD 400-900 mg & daily 50-100 mg continuously.

In the Phase 2 trials, doses were LD 900 mg Day 1 & 150 mg daily for days 2-21 every 28 days; LD 900 mg and 100 mg daily continuously; 50 mg daily continuously without a LD; and 900-1500 mg weekly. LD was reduced for cycle 2+ of the 28 day regimens.

Results

145 patients with sarcoma were entered on studies prior to December 31, 2006 and were assessed for CBR. Partial responses were seen, in one patient each, with chondrosarcoma, extra-skeletal myxoid chondrosarcoma, leiomyosarcoma and a desmoid tumor.

At lower doses with 52 patients fully evaluable for CBR, the CBR was 52% with 4 partial responses and 23 stable disease at >= 4 months.

At higher doses with 30 patients fully evaluable for CBR, the CBR was 53% with 16 stable disease at >= 4 months.

Toxicities were mainly gastrointestinal and/or fatigue. The percentage of patients with grade 0 nausea (N), vomiting (V), diarrhea (D) and fatigue (F) for lower dose perifosine (76 patients) was 46, 49, 38 and 55% respectively compared to 26, 32, 20 and 58 percent for higher dose perifosine (69 patients). The proportion of patients with grade 2+ N, V, D and F was 20, 13, 15 and 21% for lower dose perifosine and 49, 35, 42 and 25% for higher dose perifosine.

    Conclusions


    - Perifosin
'"/>




Page: 1 2 3 4

Related medicine technology :

1. AEterna Zentaris Partner, Spectrum, Discloses Detailed Phase 2 Data for Ozarelix, in BPH at Annual AUA Meeting
2. AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist JMR-132 at the AACR Annual Meeting in Los Angeles
3. AEterna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
4. AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles
5. AEterna Zentaris Reports Positive Results with Cetrorelix in BPH for Japanese Phase 2a Trial
6. terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
7. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
8. GenoLogics Announces Bioinformatics Partnership with Illumina
9. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
10. Inovio Biomedicals Partners to Present New Data from Two Cancer Immunotherapy Clinical Trials
11. Catalyst Pharmaceutical Partners, Inc. Announces Top-Line Results of Its Bioequivalence Study of CPP-109 (Vigabatrin), the Companys Investigational Drug to Treat Cocaine and Methamphetamine Addiction
Post Your Comments:
(Date:2/26/2015)... 26, 2015  Spring Bank Pharmaceuticals, Inc., a ... treatment of virus infections, today announced that ... Vice President of Finance, a newly created role. ... administrative activities, including financial planning and reporting, accounting ... J. Jensen , President and CEO. ...
(Date:2/26/2015)... 26, 2015  Lyric Pharmaceuticals Inc. today announced the ... $20.4 million. The financing, co-led by RiverVest Venture Partners, ... Aperture Venture Partners. Lyric is a ... Wurtman , M.D., M.B.A., President & Chief Executive Officer ... Officer.  In 2014, Lyric closed a seed financing round ...
(Date:2/26/2015)... Ore. , Feb. 26, 2015 ... will have the opportunity to participate in research ... when the first independent U.S. psoriasis registry begins ... a joint collaboration with the National Psoriasis Foundation ... safety reporting for secukinumab, a new biologic medication ...
Breaking Medicine Technology:Jonathan P. Freve, CPA, Joins Spring Bank Pharmaceuticals as Vice President of Finance 2First independent U.S. psoriasis registry will track drug safety and effectiveness 2First independent U.S. psoriasis registry will track drug safety and effectiveness 3
... Aug. 11, 2011 Lexicon Pharmaceuticals, Inc. ... on discovering breakthrough treatments for human disease, announced today ... president and chief executive officer, will present at the ... August 16, 2011 at 1:15 p.m. Eastern Time in ...
... Minn., Aug. 11, 2011 The City of St. Louis ... to help provide residents with some relief from the high ... the National League of Cities (NLC) – the City is ... discount cards offer city residents an average of 23 percent ...
Cached Medicine Technology:Lexicon Pharmaceuticals to Present at the Wedbush 2011 Life Sciences Management Access Conference 2St. Louis Park and the National League of Cities Bring Free Prescription Discount Card Program to Residents 2
(Date:2/27/2015)... 2015 The report “Polycystic Ovarian ... information on the therapeutic development for polycystic ovarian ... which a woman's hormones are out of balance. ... teenage girls and young women. The cause of ... R&D pipelines by identifying new targets and MOAs ...
(Date:2/27/2015)... 2015 If there is one thing that ... a head lice outbreak at their child’s school. While head ... parasite is nothing short of a nightmare for many parents ... their children, or within their child’s classroom. Just when they ... starts scratching again. , Local lice removal company, Lice ...
(Date:2/27/2015)... February 27, 2015 Qualis Health, ... organizations, has been named a finalist in the ... recognition of outstanding commitment toward continuous improvement in ... in reducing hospital readmission rates through its Communities ... are honored to receive this national recognition, which ...
(Date:2/27/2015)... 27, 2015 A fireplace can cause the ... its heat through the chimney’s flue when the fireplace is ... Tamarack Technologies has solved with the introduction of a new ... PVC pillow measuring 18" in diameter when inflated. It is ... just below the damper. This size unit fits into round ...
(Date:2/27/2015)... 27, 2015 The Connecticut Community for ... along with Alcohol and Drug Recovery Centers (ADRC), for ... these organizations were honored with the 2014 Commissioner’s Recognition ... Addiction Services. Last year, ROES achieved the ... people who are recovering from alcoholism and other drug ...
Breaking Medicine News(10 mins):Health News:Polycystic Ovarian Syndrome Therapeutics Pipeline Market H1 2015 Review Report Now Available at RnRMarketResearch.com 2Health News:Polycystic Ovarian Syndrome Therapeutics Pipeline Market H1 2015 Review Report Now Available at RnRMarketResearch.com 3Health News:Polycystic Ovarian Syndrome Therapeutics Pipeline Market H1 2015 Review Report Now Available at RnRMarketResearch.com 4Health News:Anxiety over head lice among Miami parents as surge in head lice cases reported by local lice removal company Lice Troopers 2Health News:Qualis Health Named Award Finalist for Care Transitions Work 2Health News:New DraftStopper from Tamarack Technologies Stops Heat Loss When Fireplace Not in Use 2
... risk of bacterial disease in valves at bay , , MONDAY, ... and gums may be crucial in preventing heart valve infection, ... activities such as brushing were as likely as major dental ... a dangerous infection of the lining of the heart or ...
... 9 MINRAD,International, Inc. (Amex: BUF ) ... Food and Drug Administration Center for Veterinary Medicine,to ... initiated their US product launch to the veterinary ... Inc. is an interventional pain management company,with real-time ...
... Medical Credit Crisis, YONKERS, N.Y., June 9 ... including GE Money, Citigroup, and,Chase, are pushing risky credit ... Consumer Reports, which describes the new lending,practices as akin ... covering medical costs: at about $45 billion today, it ...
... Repair, Inc.,(ICR), headquartered in Warren, Michigan, received the ... delivery of MRO Asset Management and,industrial repair services. ... solutions and selling refurbished,industrial equipment to customers around ... the annual Honda of America Manufacturing,MRO Supplier Conference ...
... findings don,t account for overall health factors and intelligence ... are more prone to memory problems than their non-smoking ... is a recognized health hazard, there has been some ... said. , "Dementia is rare among middle-aged people, but ...
... of,Labor & Industry invites the public to learn more about ... Safety Day from 10 a.m. to 2,p.m. on Wednesday, June ... event will feature an array of interactive services promoting,health and ... can,receive - free of charge - relaxing massages; a cool ...
Cached Medicine News:Health News:Good Oral Hygiene May Protect Against Heart Infections 2Health News:MINRAD International, Inc. Announces FDA Approval of Petrem(TM) Sevoflurane 2Health News:Consumer Reports: Patients 'Overdose' on Debt As Lenders, Doctors, and Hospitals Push Risky Credit to Pay for Medical Care 2Health News:Consumer Reports: Patients 'Overdose' on Debt As Lenders, Doctors, and Hospitals Push Risky Credit to Pay for Medical Care 3Health News:Consumer Reports: Patients 'Overdose' on Debt As Lenders, Doctors, and Hospitals Push Risky Credit to Pay for Medical Care 4Health News:Industrial Control Repair Named Honda of America Manufacturing's '2007 Supplier of the Year' 2Health News:Smoking Tied to Memory Loss in Middle Age 2Health News:Smoking Tied to Memory Loss in Middle Age 3
... A physician only, ... to be chirally corrext ... minimal downtime. A revolutionary ... croton oil to facilitate ...
... rapid exfoliator. Lactic Acid is is recommended for ... agents in skin care products, as well as ... long period and want to improve results. ,Lactic ... combined with the chemical free style of Peel ...
Catalyst for skin rejuvenation. Rapidly exfoliates superficial skin problems....
... a simple, effective, non-surgical treatment that works ... thereby reducing and smoothing away frown-lines and ... decade of clinical experience. Dysport was developed ... 1990s to successfully treat a number of ...
Medicine Products: