Navigation Links
AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist,JMR-132 at the AACR Annual Meeting in Los Angeles

JMR-132 could provide a new therapeutic approach for the treatment of early and metastatic breast cancer

QUEBEC CITY, April 17, 2007 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. , a global, pure play biopharmaceutical company focused on endocrine therapy and oncology, today presented an abstract outlining in vivo data for its growth hormone-releasing hormone (GHRH) antagonist JMR-132 in breast cancer, at the American Association for Cancer Research (AACR) Annual Meeting being held this week at the Los Angeles Convention Center in Los Angeles, California.


The poster #3568 "GHRH-Antagonist in Combination with Docetaxel Chemotherapy induces regression of MX-1 human experimental breast cancers," reviewed preclinical results in breast cancer for JMR-132, the Company's GHRH antagonist which binds to splice variants of the GHRH receptors found on various cancerous tumors. More specifically, the authors reported on the antitumor activity of JMR-132 in MX-1 human experimental, doxorubicin-resistant breast cancers, as well as on the anti-proliferative effect of JMR-132 in combination with docetaxel, which is frequently used for the treatment of early and metastatic breast cancer.

Binding sites were found for GHRH in the MX-1 human breast cancer cell line. The treatment of nude mice bearing MX-1 xenografts with JMR-132 at the dose of 10 (micro)g/day s.c. significantly (p<0.05) inhibited tumor growth, as shown by a 62.9% decrease in tumor volume and 47.8% reduction in tumor weight. Docetaxel at a single dose of 20 mg/kg i.p. significantly reduced tumor volume and weight by 74.1% and 58.6 %, respectively. Combination treatment with JMR-132 and docetaxel led to growth arrest of most MX-1 tumors, evidenced by an inhibition of tumor volume and weight by 97.7 %and 95.6 % respectively (p<0.001).


    - JMR-132 inhibits doxorubicin resistant in MX-1 human breast cancers

   - JMR-132 induces growth arrest or total regression when combined with

      docetaxel chemotherapy

    - JMR-132 could provide a new therapeutic approach to the treatment of

      early and metastatic breast cancer

"We are very pleased and encouraged with these results we have seen to date with JMR-132 which lend further credibility to our very promising oncology platform. By targeting patients suffering from breast cancer with confirmed GHRH receptor status, we believe we may increase our chances of success in future development programs with JMR-132 in this indication. This targeted approach is an additional example of personalized therapy which is becoming more and more the way of the future," said Dr. Jurgen Engel, Executive Vice President, Global R&D and COO of AEterna Zentaris.

About AEterna Zentaris Inc.

AEterna Zentaris Inc. is a global, pure play biopharmaceutical company focused on endocrine therapy and oncology with proven expertise in drug discovery, development and commercialization.

News releases and additional information are available at

Forward-Looking Statements

This press release contains forward-looking statements made pursuant to the safe harbor provisions of the U.S. Securities Litigation Reform Act of 1995. Statements that are not historical facts, including statements preceded by, followed by, or that include the words "believes", "anticipates", "intends", "plans", "expects", "estimates", "will," "may", "should", "approximately", and the negative or other variations of those terms or comparable terminology, are forward-looking statements. Such statements reflect management's current views, intentions, strategies and plans and are based on certain assumptions.

Forward-looking statements involve known and unknown risks and uncertainties, which could cause the Company's actual results to differ ma terially from those in the forward-looking statements. Such risks and uncertainties include, among others, the ability of AEterna Zentaris to implement its business strategies, the availability of funds and resources to pursue R&D projects, the successful and timely completion of clinical studies, the ability of AEterna Zentaris to take advantage of business opportunities in the pharmaceutical industry, uncertainties related to the regulatory process and general changes in economic conditions. Investors should consult the Company's quarterly and annual filings with the Canadian and U.S. securities commissions for additional information on risks and uncertainties relating to the forward-looking statements. Investors are cautioned not to rely on these forward-looking statements. The Company does not undertake to update these forward-looking statements.

CONTACT: Jenene Thomas, Senior Director, Investor Relations & CorporateCommunications, (418) 655-6420, ; PaulBurroughs, Media Relations (418) 652-8525 ext. 406,

Ticker Symbol: (Toronto:AEZ.),(NASDAQ-NMS:AEZS)

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


Related medicine technology :

1. AEterna Zentaris Partner Keryx Presents Phase 1 and Phase 2 Results for Anti-Cancer Compound Perifosine at ASCO Meeting
2. AEterna Zentaris Partner, Spectrum, Discloses Detailed Phase 2 Data for Ozarelix, in BPH at Annual AUA Meeting
3. AEterna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
4. AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles
5. AEterna Zentaris Reports Positive Results with Cetrorelix in BPH for Japanese Phase 2a Trial
6. terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
7. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
8. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
9. Generex Biotechnology to Make Presentations At 46th Annual Meeting of the European Society of Pediatric Endocrinology
10. Micromet, Inc. to Present at the 3rd Annual C.E. Unterberg, Towbin Emerging Growth Conference
11. Neurologix to Present at the Third Annual C.E. Unterberg Towbin Emerging Growth Conference
Post Your Comments:
(Date:10/8/2015)... Oct. 9, 2015 Johnson & Johnson (NYSE: ... immunogenicity clinical trial in Sierra Leone ... Janssen Pharmaceutical Companies. Trial recruitment is underway, and the first ... first study conducted of Janssen,s Ebola prime-boost vaccine regimen in ... Sierra Leone,s Kambia district, where ...
(Date:10/8/2015)...  Ardelyx, Inc. (NASDAQ: ARDX ), a ... diseases, today announced that clinical data for the ... at the 2015 American College of Gastroenterology (ACG) ... sustained response in IBS-C patients enrolled in the ... trial. The meeting will be held in ...
(Date:10/8/2015)... SAN DIEGO , Oct. 8, 2015 /PRNewswire/ ... cell-free molecular diagnostics, today announced the presentation of ... use of its Precision Cancer Monitoring SM ... can be critical for physicians to determine appropriate ... chief scientific officer of Trovagene is delivering the ...
Breaking Medicine Technology:
... February is American Heart Month and a time when ... on their family history of heart disease and recommit ... teaming up with the makers of Bayer® Aspirin and ... to raise $100,000 for the fight against heart disease. ...
... 2012 Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ... the Leerink Swann 2012 Global Healthcare Conference to be ... New York City.  Mr. Adrian Adams, Chief Executive Officer ... the Company and its product pipeline at 10:30 a.m. ...
Cached Medicine Technology:
(Date:10/10/2015)... ... October 10, 2015 , ... Well-known Eastern ... to be recognized by The National Law Journal for inclusion in their second ... firms across the United States who obtained the largest awards for their personal ...
(Date:10/9/2015)... California (PRWEB) , ... October 09, 2015 , ... ... Osteopathic Medicine of the Pacific Associate Dean for Graduate Medical Education J. Michael ... of the Year Award. Finley was selected for his impact on graduate medical ...
(Date:10/9/2015)... ... October 09, 2015 , ... With the FCPX LUT Vibrance pack from ... A LUT is a Lookup Table that contains a mathematical formula for modifying an ... table. This pack comes with 60 vibrant CUBE LUT files. , Inspired ...
(Date:10/9/2015)... ... October 09, 2015 , ... Smoke alarms can save lives. In fact, ... risk of dying in reported home fires in half. As part of Fire Prevention ... are property installed and maintained. , Half of home fire deaths result from fires ...
(Date:10/9/2015)... ... , ... Head Over Heels Athletic Arts gymnast, Madelyn Williams, will attend the ... in Huntsville, Texas on October 17-21. , "It's very exciting to be invited ... executive director, said. “It's a stepping stone into the U.S. elite system where Maddie ...
Breaking Medicine News(10 mins):
... Neuroscientists at MIT,s Picower Institute of Learning and Memory have ... inexplicably linked to long-term memories. The work is slated to ... "Our finding explains, at least partially, why seemingly irrelevant ... person is remembered as vividly as more significant information such ...
... HealthDay Reporter , THURSDAY, Jan. 13 (HealthDay News) -- This winter ... instead is turning out to be a more typical flu season, ... to get a flu shot, advice that seniors in particular should ... their age group the hardest, the experts added. The H1N1 flu ...
... for Injury Biomechanics ( ) has been awarded ... Research and Materiel Command for phase 2 of an ... military personnel. Specifically, blast induced brain trauma will be ... helmet design and body armor and the resulting reductions ...
... Liverpool-led consortium has received $1.5million from the Bill & ... serious disease and epidemics in sub-Saharan Africa. Streptococcus ... in sub-Sahara Africa. The funding will enable scientists ... associated with invasive pneumococcal disease, why it spreads so ...
... HealthDay Reporter , THURSDAY, Jan. 13 (HealthDay ... by patients and health professionals alike to save money ... and potentially dangerous, a new study suggests. Belgian ... deviated from recommended dosages by 15 percent or more. ...
... HealthDay Reporter , WEDNESDAY, Jan. 12 (HealthDay News) -- ... said Tuesday, breathing on her own and moving both arms ... "She has a 101 percent chance of surviving," Dr. ... told the Associated Press . "She will not die." ...
Cached Medicine News:
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: