Navigation Links
AEterna Zentaris Discloses First In Vitro Data for its PI3K,Inhibitors at the AACR Annual Meeting in Los Angeles

Second generation pyridopyrazine-urea derivative compound series show highly selective PI3K-inhibition which could be valuable for cancer treatment

QUEBEC, April 16, 2007 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. , a global, pure play biopharmaceutical company focused on endocrine therapy and oncology, today presented an abstract outlining first in vitro data on its pyridopyrazine derivatives with high selectivity for PI3K inhibition, at the American Association for Cancer Research (AACR) Annual Meeting being held this week at the Los Angeles Convention Center in Los Angeles, California.

Results

The poster #2379 entitled, "New Generation of Anilino-Substituted Pyridopyrazine-Urea Derivatives Show Highly Selective PI3K-Inhibition", reviewed for the first time, results for a preclinical development program on a new generation of pyridopyrazine derivatives which clearly indicate that these drug candidates selectively inhibit PI3K.

Furthermore, an optimization process of our already known aryl-pyridopyrazine series led to the identification of a new lead compound in this series. A medicinal chemistry program was then initiated which resulted in the synthesis of new anilino-substituted pyridopyrazines. Out of this second generation series, several derivatives also with highly-selective PI3K inhibition as well as improved cellular efficacy and better drug-like properties, were identified.

    Conclusions


         - Novel low molecular weight kinase inhibitor

         - Excellent in vitro activity against PI3K

         - High selectivity against a panel of more than 50 kinases

         - Anti-proliferative efficacy in diverse tumor cell-lines

         - Promising bioavailability observed for lead compound

         - PI3K signalling network covers enormous therapeutic potential

"We are pleased with these results which exemplify our capability of developing novel the
'"/>




Page: 1 2 3

Related medicine technology :

1. AEterna Zentaris Partner Keryx Presents Phase 1 and Phase 2 Results for Anti-Cancer Compound Perifosine at ASCO Meeting
2. AEterna Zentaris Partner, Spectrum, Discloses Detailed Phase 2 Data for Ozarelix, in BPH at Annual AUA Meeting
3. AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist JMR-132 at the AACR Annual Meeting in Los Angeles
4. AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles
5. AEterna Zentaris Reports Positive Results with Cetrorelix in BPH for Japanese Phase 2a Trial
6. terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
7. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
8. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
9. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
10. Ablynx Announces Interim Results of First Nanobody Phase I Study of ALX-0081 (ANTI-VWF)
11. Advanced Life Sciences Announces Supplemental Efficacy Data from First Pivotal Phase 3 Pneumonia Clinical Trial
Post Your Comments:
(Date:7/31/2015)... 2015  Physicians and payers alone do not ... Patients are better informed and getting increasingly involved ... This shift in power is reshaping the healthcare ... marketing. As part of this evolving ... important to educate, communicate and engage patients throughout ...
(Date:7/31/2015)... 31, 2015  In today,s ever-changing marketplace, call centers ... mobile, increasingly connected, and increasingly impatient with slow service. ... interaction channels and tools is driving call centers to ... According to research by benchmarking firm, Best ... segment in a call center study realize the impact ...
(Date:7/31/2015)... July 31, 2015  Seeger Weiss LLP is reporting that ... a warning letter to C.R. Bard, the manufacturer of ... strides to correct violations the agency found at two of ... after the FDA cited them during Inspectional Observations that occurred ... Tempe, AZ , location and on October ...
Breaking Medicine Technology:Consumers Forcing Pharmaceutical Industry to Shift its Marketing Focus from Products to Patients 2Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 3
(Date:8/1/2015)... ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director ... Appalachian Trail by stepping off Springer Mountain and heading north. Since that day, ... Phil reached Connecticut and was greeted by friends and family. He visited CCAR and ...
(Date:7/31/2015)... ... 2015 , ... When the weather turned hot and warm-season turfgrasses, such as ... called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. Incidentally, both names ... new type of sod, Super-Sod is giving away red Adirondack chairs with the Leisure ...
(Date:7/31/2015)... ... 2015 , ... Ticket Down is a reliable source for authentic tickets for ... Park. The festival will end on Sunday, August 2nd. , Music ... Lollapalooza. This unique and unbelievably popular festival attracts the best in entertainment from ...
(Date:7/31/2015)... Alexandria, VA (PRWEB) , ... July 31, 2015 ... ... Foundation) introduced its new store run by GoodThreads. The store can be accessed ... products and designs, many of which are customizable. The best part: whenever a ...
(Date:7/31/2015)... ... 2015 , ... There’s no better way to enjoy the summer weather than ... the next meal, making July the most appropriate to be National Hot Dog Month. ... , Make the next cookout different than the ones in the past. Celebrate National ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... at Buffalo School of Dental Medicine ,they say that ... an accurate early-warning system of risk of dying from ... in a population with a high incidence of diabetes. ... use of panoramic dental radiographs as a screening tool ...
... temperature by just a few degrees minimises brain damage resulting ... arrest - there's a great danger that the brain will ... run the risk of permanent brain damage. It's been suggested ... for oxygen and this may protect it after a cardiac ...
... an oral habit characterized by rhythmic activity of the jawbone ... sleep. It has been linked to headaches, joint discomfort// and ... both the person with bruxism as well as his or ... European countries, aimed to collect information on the prevalence of ...
... diet high in cholesterol and animal protein is linked to ... and esophagus that has been increasing rapidly.// The researchers also ... folic acid, vitamin C and vitamin B6 were associated with ... rate of a specific type of esophageal and stomach cancer, ...
... that causes a rare bone disease in which the body ... treatments for osteoporosis. According to Dr. Michael Levyn, director of ... finding will help bone researchers understand why the body loses ... ,Later, Levine explained the researchers studied DNA from ...
... new study shows there is some truth in the 'use ... brain active. It is long been believed that mental stimulation ... Rush Alzheimer's Disease Centre in the US now reveal new ... Religious Orders Study, involving the cognitive health of older Catholic ...
Cached Medicine News:Health News:Mutation connected to Osteoporosis 2
#2 TigerWire, a white suture with black spiral markings, was created specifically for arthroscopic surgeons that require superior suture visibility, easier arthroscopic orientation and motion determi...
TigerStick is a white #2 FiberStick with black stripes and a stiffened, 12 inch, waxed end. It is especially useful when motion determination and alternating colored sutures are required in the arthr...
... an easy one step approach to creating ... the Bio-Tenodesis Driver. Instead of using a ... retrograde through the tip of the Bio-Tenodesis ... as a suture shuttle for passage of ...
... is an ultra-high strength 2 ... long chain polyethylene structure of ... footprint of the FiberTape is ... cuff tissue where tissue pull-through ...
Medicine Products: