Navigation Links
ACE-011 Improves Multiple Myeloma Bone Disease in a Preclinical,Model

are for a phase 2 clinical trial in multiple myeloma later this year".

Acceleron is developing therapeutics that addresses the clinical consequences of cancer, such as bone loss and/or muscle loss, as well as treatments that directly target the underlying tumor. Given the improving therapeutic outcomes leading to more cancer patients living longer with their disease, the frequency of secondary consequences of cancer is increasing.

About ACE-011

ACE-011, a novel bone anabolic agent currently in a phase 1 clinical trial, is a protein therapeutic based on the activin receptor IIA. In numerous preclinical models of bone loss, ACE-011 has demonstrated beneficial effects on both trabecular and cortical bone. ACE-011 increased bone mineral density, improved bone architecture, increased the mineral apposition and bone formation rates and improved bone mechanical strength. These effects have been demonstrated in therapeutic models of bone loss in which ACE-011 has stimulated bone formation - a significant unmet medical need that is underserved by current treatments for bone loss.

About Multiple Myeloma

Multiple myeloma is a malignancy of plasma cells in the bone marrow that disrupts normal bone marrow function. Myeloma cells invade and destroy the bone surrounding the marrow cavity leading to rapid and widespread osteoporosis and osteolytic bone lesions, resulting in fractures, vertebral compressions and bone pain. Intravenous bisphosphonates are the current standard of care, but significant unmet medical need remains since most patients will still have serious bone complications despite treatment. According to the International Myeloma Foundation, there are an estimated 750,000 people worldwide multiple myeloma. In the US and EU, there are approximately 80,000 myeloma patients whose disease has affected their bones.

About Acceleron Pharma

Acceleron is a privately held biopharmaceutical company committed to discover, develop,
'"/>




Page: 1 2 3

Related medicine technology :

1. Mayo Clinic News Release: Mayo Clinic-led Study Improves Breast Cancer Risk Prediction in Women with Atypia
2. Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen
3. Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid Arthritis Compared to a Current Standard of Care
4. Data Presented at SLEEP 2007 Shows VEC-162 Improves Sleep Onset and Maintenance vs. Placebo
5. Ivivis PEMF Technology Significantly Improves Neuron Survival in Parkinsons Disease Model, Study Finds
6. Study Shows Velcade Plus Doxil Improves Survival in Previously Treated Patients With Multiple Myeloma
7. Adding Thalidomide to Standard Therapy Improves Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
8. First-of-Its-Kind Study Shows Botox (Botulinum Toxin Type A) Significantly Improves Idiopathic Detrusor Overactivity (IDO) in Patients With Symptoms of Overactive Bladder
9. Newly Published Study Reveals Femara Improves Chances for Harder to Treat Early Breast Cancer Relapse in Postmenopausal Women
10. Once Daily, Extended-Release Ropinirole Improves Parkinsons Symptoms in Patients not Optimally Controlled With Levodopa
11. Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple Myeloma and Waldenstroms Macroglobulinemia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: ACE Improves Multiple Myeloma Bone Disease Preclinical Model
(Date:10/22/2014)... SANTA CLARA, Calif. , Oct. 22, 2014 /PRNewswire/ ... today announced the introduction of the cQUB™-1 (cQuest Ultrasound ... cQUB white-label ultrasound systems designed and manufactured by Cephasonics ... brand name and model number. Cephasonics will be showcasing ... 2014 being held this week in Chongqing, ...
(Date:10/22/2014)... , Oct. 22, 2014  Quest Diagnostics (NYSE: ... information services, today announced that its Board of Directors ... a director, effective December 1, 2014. Including Dr. Leiden, ... is the Chairman, President and CEO of Vertex Pharmaceuticals. ... scientific and commercial experience in the pharmaceutical and biotechnology ...
(Date:10/22/2014)... Calif. , Oct 22, 2014 Antigen ... Irvine, California , announced the receipt of ... Business Innovation Research award (SBIR) from the National Institute of Dental ... fund the development of a Pan-HIV Protein Microarray Chip, ... HIV-1 and HIV-2 subtypes and aid in the development ...
Breaking Medicine Technology:Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 3Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2
... Oct. 13 The Care Continuum Alliance ... Award for the "Greatest Impact on Health" at ...  The ALL/PHASE protocol, which utilizes low-cost and generic medications ... successfully implemented in Kaiser Permanente communities, including those served ...
... Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna -- OOSTERHOUT, Netherlands, Oct. 13 ... ... (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
Cached Medicine Technology:Kaiser Permanente's ALL/PHASE Initiative Wins 2010 Care Continuum Alliance Quality Impact Award for Greatest Impact on Health 2Kaiser Permanente's ALL/PHASE Initiative Wins 2010 Care Continuum Alliance Quality Impact Award for Greatest Impact on Health 3Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 2Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 3Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 4Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 5Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 6Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 7Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 8Luminex Corporation Hosts Eighth Annual Planet xMAP Europe in Vienna 9
(Date:10/25/2014)... Background: , In 1998 Bob Savage founded the ... in the field of establishing recovery community organizations. Bob ... when he retired, he set out to answer a couple ... , 1. Where are the people in recovery ... 2. Can the recovery community be organized to advocate for ...
(Date:10/25/2014)... The Wehrman Collaborative, LLC ... for disabled users by disabled users, has granted ... Mackin Educational Resources of Burnsville, Minnesota, for their ... to the Minnesota Alliance for Patient Safety of ... website. Both organizations have met WeCo’s ...
(Date:10/25/2014)... QueenBeeTickets.com has a variety of tickets for ... prices. Bob Seger & The Silver Bullet Band tickets ... are going on sale October 25 and are expected ... browse the selection of tickets for Bob Seger & ... singer is touring North America beginning next month, and ...
(Date:10/25/2014)... York (PRWEB) October 25, 2014 ... lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) filed against Boston ... in U.S. District Court, Southern District of West ... Judgment on Punitive Damages in a group of ... a ruling issued on October 21st, U.S. District ...
(Date:10/25/2014)... Limbkeepers® announced today that they will be featured ... Jr, airing 1st QTR 2015 via Discovery Channel. Dates ... will focus on Limbkeepers® non compression knit sleeves, a ... arms, hands, and legs from abrasion, skin tears and ... help reduce injuries, allow for continued daily activities, and ...
Breaking Medicine News(10 mins):Health News:CCAR Accepting Nominations for the Bob Savage Recovery Advocate of the Year Award 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 3Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2
... It was a "common sense" decision to start the ... of the stroke belt. , "We wanted to give better ... of the Department of Neurology at the Medical College of ... 2000 and Hess and his colleagues were frustrated that nearly ...
... Researchers at UT Southwestern Medical Center have developed what ... new imaging technique to diagnose brain tumors. The unique test ... are located in areas of the brain too dangerous to ... a definitive diagnosis of cancer based on imaging of a ...
... , THURSDAY, Jan. 26 (HealthDay News) -- Popular cholesterol-lowering statins may ... a new study shows. Hepatitis B, an inflammation of the liver ... causes of liver cancer. This is not the first ... Other studies have hinted that these drugs may play a role ...
... (HealthDay News) -- Positive reinforcement, such as receiving small, ... seems to help patients with high blood pressure take ... of black Americans. The findings are significant because ... and death, the researchers from the Center for Healthful ...
... lung clearance index (LCI) is a sensitive non-invasive marker of ... according to a new study from Australian researchers. "We ... especially in the presence of airway inflammation and Pseudomonas aeruginosa," ... the Sydney Children,s Hospital. "LCI may not only be a ...
... Reporter , THURSDAY, Jan. 26 (HealthDay News) -- The rate ... dramatic upturn since 2004, reversing a trend of decline throughout ... place outside of the traditional hospital setting increased 29 percent ... to 0.72 percent -- almost 30,000 births -- according to ...
Cached Medicine News:Health News:Georgia Bio honors biotech company that enables stroke care 2Health News:Georgia Bio honors biotech company that enables stroke care 3Health News:Diagnostic brain tumor test could revolutionize care of patients 2Health News:Statins May Stave Off Liver Cancer in People With Hepatitis B 2Health News:Positive Reinforcement May Help Patients Take Their Meds 2Health News:Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index 2Health News:More U.S. Babies Born at Home: Report 2Health News:More U.S. Babies Born at Home: Report 3
... The Stryker Universal ACL Instrumentation ... utilized with a variety of anterior ... the Stryker Universal ACL Instrumentation system ... possible to obtain more reproducible anatomical ...
... Waived Drug Tests are easy to use; ... demonstrate excellent correlation with laboratory GC/MS testing ... in minutes instead of days. These tests ... in clinics, physician offices and rehabilitation centers., ...
... Test is an in vitro immunoassay ... of bladder tumor antigen in urine ... cancer. This test is indicated for ... management of bladder cancer patients ...
... Drug Screen Tests are available in 14 ... (Ecstasy). Designed using Microgenics Antibody Technology, the ... point of care immunoassay targeted to detect ... MDA and MDEA but no cross-reactivity to ...
Medicine Products: