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ACE-011 Improves Multiple Myeloma Bone Disease in a Preclinical,Model

are for a phase 2 clinical trial in multiple myeloma later this year".

Acceleron is developing therapeutics that addresses the clinical consequences of cancer, such as bone loss and/or muscle loss, as well as treatments that directly target the underlying tumor. Given the improving therapeutic outcomes leading to more cancer patients living longer with their disease, the frequency of secondary consequences of cancer is increasing.

About ACE-011

ACE-011, a novel bone anabolic agent currently in a phase 1 clinical trial, is a protein therapeutic based on the activin receptor IIA. In numerous preclinical models of bone loss, ACE-011 has demonstrated beneficial effects on both trabecular and cortical bone. ACE-011 increased bone mineral density, improved bone architecture, increased the mineral apposition and bone formation rates and improved bone mechanical strength. These effects have been demonstrated in therapeutic models of bone loss in which ACE-011 has stimulated bone formation - a significant unmet medical need that is underserved by current treatments for bone loss.

About Multiple Myeloma

Multiple myeloma is a malignancy of plasma cells in the bone marrow that disrupts normal bone marrow function. Myeloma cells invade and destroy the bone surrounding the marrow cavity leading to rapid and widespread osteoporosis and osteolytic bone lesions, resulting in fractures, vertebral compressions and bone pain. Intravenous bisphosphonates are the current standard of care, but significant unmet medical need remains since most patients will still have serious bone complications despite treatment. According to the International Myeloma Foundation, there are an estimated 750,000 people worldwide multiple myeloma. In the US and EU, there are approximately 80,000 myeloma patients whose disease has affected their bones.

About Acceleron Pharma

Acceleron is a privately held biopharmaceutical company committed to discover, develop,
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