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ACC Presentation Indicates Interleukin-1 Gene Variants Determine,Increased Risk for Coronary Artery Disease from Oxidized,Phospholipids

WALTHAM, Mass.--(BUSINESS WIRE)--Mar 27, 2007 - Interleukin Genetics, Inc. (AMEX:ILI) and collaborators at the University of California San Diego today reported at the American College of Cardiology annual meeting that associations between coronary artery disease (CAD) and both oxidized phospholipids (OxPL) and Lp(a) levels appear to be dependent on pro-inflammatory variants of the interleukin-1 (IL-1) genes.

In a presentation titled "The Influence of Oxidized Phospholipids and Lp(a) Lipoprotein on Coronary Artery Disease Is Conditional Upon Genotype at the Interleukin-1 Region," the investigators reported that in patients with the pro-inflammatory IL-1 genotypes, higher levels of OxPL or Lp(a) were associated with significantly increased risk for CAD (P less than 0.01). This effect was strongly accentuated in patients less than 60 years old (P=0.0001). In contrast, patients who did not express, the pro-inflammatory IL-1 genotypes demonstrated no association between OxPL levels and CAD. These findings were found to be independent of other standard risk factors, including C-reactive protein.

"Oxidized phospholipids play a critical role in the initiation and progression of cardiovascular disease. These new data suggest a novel and clinically relevant biological link between pro-inflammatory IL-1 genotypes, oxidation of phospholipids and predisposition to CAD in younger individuals," said Sotirios Tsimikas, M.D., Associate Professor of Clinical Medicine and Director of Vascular Medicine, University of California San Diego.

The study was conducted under the direction of Drs. Joseph Witztum and Sotirios Tsimikas from the Divisions of Endocrinology and Metabolism and Cardiovascular Diseases, University of California San Diego and involved collaborators from Interleukin Genetics, the University of Sheffield, England and the Geisinger Center for Health Research.

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