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12-Month Study Demonstrated Tolerability and Efficacy of DAYTRANA,(methylphenidate transdermal system)

luding, but not limited to the impact of those on Shire's Attention Deficit and Hyperactivity Disorder ("ADHD") franchise; patents, including but not limited to, legal challenges relating to Shire's ADHD franchise; government regulation and approval, including but not limited to the expected product approval dates of SPD503 (guanfacine extended release) (ADHD) and SPD465 (extended release triple-bead mixed amphetamine salts) (ADHD); Shire's ability to secure new products for commercialization and/or development; Shire's ability to benefit from its acquisition of New River Pharmaceuticals Inc.; and other risks and uncertainties detailed from time to time in Shire plc's filings with the Securities and Exchange Commission, particularly Shire plc's Annual Report on Form 10-K for the year ended December 31, 2006.

Daytrana(TM) is a trademark of Shire Pharmaceuticals Ireland Limited.

CONTACT: Marion E. Glick, +1-212-601-8273, +1-917-301-4206, on site atAPA, , or Jennifer Anello, +1-212-601-8132,+1- 203-470-0836, on site at APA, marion.glick@porternovelli.com jennifer.anello@porternovelli.com

Web site: http://www.shire.com/http://www.DAYTRANA.com/

Ticker Symbol: (NASDAQ-NMS:SHPGY),(Toronto:SHQ.)

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