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UCSF, Sanofi Collaborate to Find New Diabetes Cures
Date:1/10/2012

ending beyond simpler, funded-research agreements to create a two-way partnership in which scientists on both sides contribute technology and expertise to identify drug targets and test their potential.

"Sanofi is pleased to collaborate with the Diabetes Center at UCSF to combine expertise in employing new technologies for the development of innovative diabetes therapies," said Pierre Chancel, Senior Vice President, Diabetes Division, Sanofi. "The potential resulting drug discovery projects will supplement our integrated solutions model for diabetes management and help Sanofi continue to deliver best-in-class solutions to people living with diabetes."

Together, the team will assess and validate potential drug targets from a UCSF library of roughly 100,000 small interference RNAs (siRNA) – molecules that play a crucial role in turning on and off genes, including the gene that produces insulin. They also will identify Sanofi compounds that might be effective in regulating those molecules, study the impact those compounds have on UCSF laboratory models of diabetes and assess their therapeutic potential.

In the United States alone, 46 percent of adults had diabetes or pre-diabetes in 2010, according to the Centers for Disease Control & Prevention (CDC), which projects a full third of Americans will have the disease in 2050. It is the leading cause of blindness and kidney failure, a major cause of heart disease and stroke, and the seventh-highest cause of death. Diabetes care costs $116 billion each year in the United States alone, according to the CDC, with an additional $58 billion toll in lost productivity and early mortality.

The initial project, intended as a pilot for broader joint research into diabetes, will operate under the oversight of an expert panel from UCSF and Sanofi, and focus on beta cells, drawing on the expertise of three renowned UCSF Diabetes Center researchers and their laboratories:

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SOURCE Sanofi and University of California, San Francisco
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