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Tengion Reviews Pipeline Progress at First Analyst and Investor Meeting; Strategic & Clinical Updates Provided for Regenerative Medicine Programs
Date:10/27/2010

unmet medical need.  Tengion has now published or presented consistently positive data on the effect of its approach on kidney function in four different animal models of chronic kidney disease. Two of the models have been conducted for a sufficiently long period of time to demonstrate durability at six months and one year, long enough to impact survival.

  • In October 2010, Tengion presented new research data in a podium presentation at the American Society for Transplantation's Annual Scientific Exchange in Orlando, FL.  The presentation highlighted early data from a canine model of chronic kidney disease demonstrating promising improvements in kidney function with a regenerative autologous cellular therapy approach to increase kidney mass and improve kidney function.  Specifically, the presented data showed improvements in kidney filtration, protein balance, and weight gain in treated animals compared to a control group.  Effects in a pilot study have persisted through the first three months after treatment.  A follow-up study has demonstrated efficacy as early as seven weeks after implantation.  The studies are designed to monitor progression over a six-month period and both studies are ongoing.  Tengion expects to announce further results from this study later in the fourth quarter of 2010.
  • In September 2010, Tengion presented one-year follow-up data from the Neo-Kidney Augment program in a podium presentation at the 2nd Annual Symposium on Stem Cell Translation of the International Society for Cellular Therapy in San Francisco.  The presentation highlighted new results demonstrating success with the Company's targeted autologous cellular therapy approach to kidney regeneration in a widely accepted rodent model of obesity, diabetes and hypertension.  At one year of age, the treated animals were reported to have demonstrated improved kidney function, delayed disease progr
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