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Takeda Completes Settlements With All Defendants in U.S. Patent Litigation Involving ACTOS® (pioglitazone HCI), ACTOplus met® (pioglitazone HCl and metformin HCl) and duetact® (pioglitazone HCl and glimepiride)
Date:12/21/2010

e taking ACTOplus met or ACTOplus met XR.

ACTOS, ACTOplus met, ACTOplus met XR, and duetact are not for patients with type 1 "juvenile" diabetes or diabetic ketoacidosis.

Warning Specific to duetact: The chance of death from serious heart or blood vessel problems may be higher when using a sulfonylurea, an ingredient in duetact.

Precautions

ACTOS may cause low blood sugar when taken in combination with insulin or sulfonylureas. Lightheadedness, shakiness, dizziness, or hunger may mean that a patient's blood sugar is too low. Patients should talk to their doctor if low blood sugar is a problem for them.

Some people taking ACTOS, ACTOplus met, ACTOplus met XR, or duetact may experience mild-to-moderate swelling of legs and ankles, anemia, and weight gain.

If a patient is of childbearing age, they should talk to their doctor before taking ACTOS, ACTOplus met, ACTOplus met XR, or duetact, as this could increase their chance of becoming pregnant. Patients should talk to their doctor if they are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

Patients should not take ACTOS, ACTOplus met, ACTOplus met XR, or duetact if they have active liver disease. A doctor should perform a blood test to check for liver problems before a patient starts therapy and periodically thereafter. Patients should talk to their doctor immediately if they experience nausea, vomiting, stomach pain, unusual tiredness, loss of appetite, dark urine, or yellowing of the skin or eyes.

Some patients have experienced visual changes while taking ACTOS, ACTOplus met, ACTOplus met XR, or duetact. If a patient experiences vision problems, they should consult their doctor immediately.

Some people, particularly women, are at higher risk of having bone
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SOURCE Takeda Pharmaceuticals North America, Inc.
Copyright©2010 PR Newswire.
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