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Spherix Announces Post-Hoc Analysis of Phase 3 Trial With D-Tagatose in Diabetes
Date:12/2/2010

humans to clarify the mechanism of action of D-tagatose in modulating triglycerides and glucose in the metabolic syndrome.Table 1. Correlations Between Clinical MeasuresHbA1cBMITGHbA1c1

0.722

0.801BMI0.722

1

0.718TG0.801

0.718

1Values are Pearson product-moment correlation coefficients, p less than or equal to 0.10Table 2. Differences Between CountriesUSAIndiameanmeanpBMI28.3

25.8

<0.00001TG189

171

0.43Units: HbA1c %, BMI kg/m2 , TG mg/dlReferencesBloomgarden ZT, Dodis R, Viscoli CM, Holmboe ES, Inzucchi SE. Lower baseline glycemia reduces apparent oral agent glucose-lowering efficacy: a meta-regression analysis. Diabetes Care. 2006 Sep;29(9):2137-9.

Guilherme,  Adilson, Virbasius, Joseph V., Puri, Vishwajeet and Czech, Michael P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes, Nature Reviews - Molecular Cell Biology, 2008, 9, 367-377.

Khan, Haseeb Ahmad. Clinical significance of HbA1c as a marker of circulating lipids in male and female type 2 diabetic patients, Acta Diabetologica, 2007, 44(4), 193-200.

Laustsen, P. G. et al. Lipoatrophic diabetes in Irs1-/-/Irs3-/- double knockout mice. Genes Dev. 16, 3213–3222 (2002).

Moitra, J. et al. Life without white fat: a transgenic mouse. Genes Dev. 12, 3168-3181 (1998).

Parks, E.J. 2002. Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations" British Journal of Nutrition, 87: S247-253.doi:10.1079/BJN/2002544. PMID 12088525.

Shimomura, I. et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12, 3182-3194 (1998).

Sovik, O., Vestergaard, H., Trygstad, O. & Pedersen, O. Studies of insulin resistance in c
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Related medicine technology :

1. Spherix Reports Second Quarter Earnings
2. Growth Achieved in Spherixs Health Sciences Consulting Business
3. Spherix D-tagatose to be Supplied by Inalco SpA
4. Spherix Expands Phase 3 Naturlose Diabetes Trial Outside of the U.S.
5. Spherix Postpones 2009 Annual Shareholders Meeting to Share Interim Diabetes Clinical Trial Data
6. Spherix Elects New Independent Director, and Elects Chairman of the Board
7. Spherix Reports First Quarter 2009 Earnings
8. Spherix Announces Positive Phase 2 Study Results
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10. Spherix to Present at Annual OneMedPlace Finance Forum and at EBD Biotech Showcase in San Francisco
11. Spherix Reports Third Quarter 2009 Earnings
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