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Silence Therapeutics Signs Collaboration with miRagen Therapeutics to Evaluate Delivery of Novel microRNA-based Therapeutics
Date:1/9/2012

ce/seniormanagementteam.htm">Thomas Christély, Chief Executive Officer of Silence Therapeutics, said: "We are delighted to be collaborating with miRagen. This is the third collaboration that we have recently signed to explore the use of Silence's delivery technologies for microRNAs, and the second that utilizes our novel DBTC delivery system that specifically delivers RNAi therapeutics to the liver. Whilst we remain internally focused on the delivery of our siRNA therapies, we continue to broaden the potential value of our proprietary delivery systems by collaborating with partners. Functional delivery to target cells is widely recognized as one of the greatest challenges facing most nucleic acid therapies. Our three proprietary RNAi delivery systems, AtuPLEX™, DACC and DBTC deliver effective doses of RNAi to key intracellular targets in vascular endothelium, lung and liver respectively, and provide our partners with a growing range of solutions to overcome their delivery challenges."

William S. Marshall, President and Chief Executive Officer of miRagen Therapeutics, said: "We are very pleased to have entered into this agreement with Silence Therapeutics, which gives us the opportunity to evaluate the efficacy of a promising delivery system in the context of microRNA manipulation.  This is another example of miRagen's commitment to explore the potential of cutting-edge technologies with the ultimate goal of better serving patients in need."

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About Silence Therapeutics plc (http://www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading biotechnology company dedicated to the discovery, development and del
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