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Sequenom Reports Fourth Quarter and Full Year 2010 Financial Results
Date:3/8/2011

trics and Gynecology. The performance of a massively parallel shotgun sequencing based assay for noninvasive detection of fetal aneuploidy was evaluated. The data set consisted of 480 plasma samples from pregnant women with high risk indicators for fetal aneuploidy collected under an Institutional Review Board approved protocol. Utilizing 449 analyzable samples, all 39 trisomy 21 (T21) samples were correctly identified, while one of the 410 euploid samples was misclassified as T21. The overall classification in this study demonstrated 100% sensitivity (95% CI: 89% to 100%) and 99.7% specificity (95% CI: 98.5% to 99%).

Age-related Macular Degeneration Program Update – Sequenom CMM has completed the development of its SensiGene AMD laboratory developed test. In December 2010, Sequenom CMM completed an in-house verification study and an in silico validation study. A manuscript describing this study has been submitted for publication. The company anticipates that Sequenom CMM will launch the AMD LDT as a testing service to physicians by mid-2011.

Commercial Leadership Update – As part of the preparation for expanded commercial activities, William Welch joined the company in January 2011 as senior vice president of diagnostics. Mr. Welch will be responsible for all commercial aspects of the company's diagnostics business.

Note to Investors: As previously announced, Sequenom will hold a conference call to discuss fourth quarter and 2010 full-year financial results today, March 8, 2011, beginning at 2:00 p.m. Pacific Time. You can listen to this call by dialing 1-866-713-8562 for domestic callers or +1-617-597-5310 for international callers, and entering passcode 42809027. Those interested in listening to the conference call live via the internet may do so be visiting http://ir.sequenom.com.

About Sequenom Center for Molecular MedicineSequenom Center for Molecular
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