Roche Announces Positive Results in Solid Tumors Using Human Monoclonal Antibody Against IGF-...(arcoma as well as other cancers said La...),Health

Date:10/23/2007

arcoma as well as other cancers," said Laurence Baker, DO, professor of Medicine and Pharmacology at the University of Michigan and the Executive Director, SARC. "With Roche's considerable expertise in oncology and SARC's vast network of physicians and institutions, we look forward to determining the potential of R1507 in this important disease area."

About Ewing's Sarcoma

The Ewing's family of tumors (EFT) includes primary tumors of bone (classic Ewing's sarcoma, primitive neuroectodermal tumor, and Askin tumor) and extraosseous primary tumors {National Cancer Institute}. Studies using immunohistochemical markers, cytogenetics, molecular genetics, and tissue culture indicate that these tumors are all derived from the same primordial stem cell. EFTs account for 4 percent of childhood and adolescent malignancies. The estimated incidence (US) is approximately 300 new cases per year. The median age for patients with EFT is 15 years and more than 50 percent of patients are adolescents. There is a slight male predominance and the lower limbs are affected in 40 percent of the patients.

Approximately 20 to 30 percent of the patients with ETB have overt metastases at the time of diagnosis. However, outcomes for patients with metastatic disease have improved little during the last 20 years. Approximately 25-30 percent survival could be achieved with current therapies for patients who present with metastatic disease at initial diagnosis.

About Roche

Hoffmann-La Roche Inc. (Roche), based in Nutley, N.J., is the U.S. pharmaceuticals headquarters of the Roche Group, one of the world's leading research-oriented healthcare groups with core businesses in pharmaceuticals and diagnostics. For more than 100 years in the U.S., Roche has been committed to developing innovative products and services that address prevention, diagnosis and treatment of diseases, thus enhancing people's health and quality of life. An employer of choice, in 2007 Roche was named
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SOURCE Hoffmann-La Roche Inc. Copyright©2007 PR Newswire. All rights reserved

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