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Results From Two Phase II Trials Add to Understanding of Ticagrelor (BRILINTA(TM)) and How it Works in the Body
Date:11/18/2009

romes, a rapid and sustained antiplatelet effect is desirable since patients are at highest risk for events soon after they present with symptoms," commented Dr. Paul A. Gurbel, Director of the Sinai Center for Thrombosis Research, Baltimore, MD, and Principal Investigator of both the ONSET/OFFSET and RESPOND studies. "Today's data add to the growing body of evidence to understand how ticagrelor works, and how it affects platelets in the body."

About the ONSET/OFFSET Study(1)

The ONSET/OFFSET trial was a randomized multicenter, double-blind, parallel-group study of patients with stable CAD on aspirin therapy. This trial was designed to assess the onset and rate of offset of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable CAD. 123 patients with stable CAD on aspirin therapy received ticagrelor (180 mg load, then 90 mg twice daily [n=57]), clopidogrel (600 mg load, then 75 mg once daily [n=54] or placebo (n=12) for 6 weeks. The total duration of the study for each patient was approximately 10 weeks.

About the RESPOND Study(2)

The RESPOND study was a phase II, randomized, multicenter, international trial designed to assess the effect of ticagrelor in stable CAD patients (n=98) responsive and non-responsive to clopidogrel. In a 2-way crossover design, non-responders (n=41) and responders (n=57) randomly received either clopidogrel (600 mg load, then 75 mg once daily) or ticagrelor (180 mg load, then 90 mg twice daily) for 14 days during period one. In Period 2, all non-responders switched treatment and half of the responders continued with the same therapy while the remaining switched. The study set out to investigate the antiplatelet effect of ticagrelor in patients non-responsive to clopidogrel and examined the effect after switching between agents.

About Coronary Artery Disease (CAD)

Coronary artery disease, also called coronary heart disease, is
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SOURCE AstraZeneca
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