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Research: Popular Diabetes Medications Associated with Increase in Bone Fractures
Date:6/8/2009

o been associated with cardiovascular issues. Troglitazone, the third of three major drugs in the TZD class, was withdrawn from the market due to increased risk of drug-induced liver failure.

New Findings Contradict Pancreatitis Risk from Incretin Mimetics

New research suggests that the medications known as incretin mimetics -- which include exenatide and sitagliptin -- do not increase the risk of pancreatitis in patients with diabetes, contradicting previous case reports concerning the drug class that led to strong FDA warnings.

Researchers from Medco reviewed the pharmacy and medical claims of 123,621 patients with diabetes between the ages of 18 and 63 who were non-insulin users. Among the 9,260 patients taking exenatide, less than one-half of 1 percent (0.44 percent) experienced an episode of acute pancreatitis. Among the 2,143 patients taking sitagliptin, a drug with a mechanism of action related to that of exenatide, acute pancreatitis was identify in only 6 patients (0.28 percent). The rates of pancreatitis were comparable in the study's control group, which saw a 0.39 percent incidence.

While the study was descriptive, authors state it suggests that there was no increased risk of pancreatitis among patients taking either of the two drugs over patients not taking the drugs.

Diabetes Patients on Clopidogrel and Proton Pump Inhibitors at Greater Risk for Cardiovascular Events

New research from the Clopidogrel Medco Outcomes Study (CMOS) has revealed an increased risk for major cardiovascular events in patients with diabetes who take clopidogrel (the active ingredient in Plavix(R)) and proton pump inhibitors (PPIs) together. A growing body of evidence highlights the risk of taking the two drugs together; however, this latest study is particularly important due to the increased risk of cardiovascular disease in people with diabetes.

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SOURCE Medco Health Solutions, Inc.
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