Navigation Links
New Data on Patient-Reported Improvements in Quality of Life Measures and Other Clinical Responses in Moderate to Severe Rheumatoid Arthritis Patients Taking Cimzia® (certolizumab pegol) Highlighted at American College of Rheumatology Meeting
Date:11/7/2011

coses are endemic.

Malignancies

During controlled and open-labeled portions of CIMZIA studies of Crohn's disease and other diseases, malignancies (excluding non-melanoma skin cancer) were observed at a rate of 0.5 per 100 patient-years among 4,650 CIMZIA-treated patients versus a rate of 0.6 per 100 patient-years among 1,319 placebo-treated patients. In studies of CIMZIA for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 CIMZIA-treated patients and one case of Hodgkin lymphoma among 1,319 placebo-treated patients.  In CIMZIA RA clinical trials (placebo-controlled and open label) a total of three cases of lymphoma were observed among 2,367 patients.  This is approximately 2-fold higher than expected in the general population.  Patients with RA, particularly those with highly active disease, are at a higher risk for the development of lymphoma. The potential role of TNF blocker therapy in the development of malignancies is not known.

Malignancies, some fatal, have been reported among children, adolescents, and young adults who received treatment with TNF-blocking agents (initiation of therapy less than or equal to 18 years of age), of which CIMZIA is a member.  Approximately half of the cases were lymphoma (including Hodgkin's and non-Hodgkin's lymphoma, while the other cases represented a variety of different malignancies and included rare malignancies associated with immunosuppression and malignancies not usually observed in children and adolescents.  Most of the patients were receiving concomitant immunosuppressants.  

Cases of acute and chronic leukemia have been reported with TNF-blocker use.  Even in the absence of TNF-blocker therapy, patients with RA may be at a higher risk (approximately 2-fold) than the general population for developing leukemia.

Heart Failure

Cases of worsening congestive heart failure (CHF) a
'/>"/>

SOURCE UCB
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Amylin to Present Data Showing Investigational Metreleptin Treatment Led to Long-Term Improvements in Diabetes and Lipid Control in Patients with Lipodystrophy
2. QNEXA® Phase 3 Data in The Lancet Show Significant Weight Loss and Broad Improvements in Co-Morbidities
3. NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development
4. Reportlinker Adds Nanotechnology in Drug Delivery - Technological Improvements and Novel Approaches to Fulfill High Potential
5. Terumo Cardiovascular Systems Reaches Agreement on Terms of Consent Decree With FDA Regarding Quality System Improvements
6. Photocure Announces Positive Allumera™ Trial Results for Delivering Significant Skin Appearance Improvements
7. Improvements in Recurrence-Free Survival in Early Stages of Colorectal Cancer Will Limit Growth of Drug Treatment Opportunities for Advanced Disease
8. Neupro® (Rotigotine) Provided Clinically Relevant Improvements in Health-Related Quality of Life for People with Parkinsons Disease
9. Ekahau RTLS Enables Improvements in Staff Safety in Austrian Psychiatric Hospital
10. Data Presented at the European Working Group on Gaucher Disease Demonstrate Continuous Improvements in Bone Mineral Density for VPRIV(R) (Velaglucerase Alfa) Through 69 Months
11. Phase 2 Trial of LX4211 Demonstrates Significant and Rapid Improvements in Multiple Parameters in Type 2 Diabetic Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... Research explores data on treatments for ... to   be presented Shire plc ... specialty biopharmaceutical company, announces that it will present scientific ... Association (APA) 166th Annual Meeting in San ... represent Shire,s ongoing commitment to the clinical research of ...
(Date:5/17/2013)... , Puerto Rico , May 17, ... central and western Puerto Rico , Caribbean ... PR) Center has improved its radiation therapy capabilities with the ... Puerto Rico . Versa HD offers clinicians ... range of tumors throughout the body, while also enabling treatment ...
(Date:5/17/2013)... Inc. (NASDAQ: ATOS ), The Breast Health Company™, ... Financial Officer & General Counsel, will present at the Second ... in New York City at the ... scheduled to begin at 3:30 p.m. EDT and will be ... to www.atossagenetics.com . For more information and ...
Breaking Medicine Technology:Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 2Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 3Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 4Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 5Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 6Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 7Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 8Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 9Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 10Puerto Rico's Caribbean Imaging and Radiation Therapy Center Orders Elekta's New Versa HD System for Treatment of Cancer Patients 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 3
(Date:5/20/2013)... (PRWEB) May 20, 2013 The ... Confectionery, Snacks, Breakfast Cereals, Baking Mixes & Flour, ... Conventional) & Geography — Global Trends & Forecasts ... product market with analysis and forecasting of the ... also identifies the driving and restraining factors for ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 B. ... dedicated exclusively to healthcare providers, has been retained ... search for Oswego Hospital in Oswego, N.Y. ... industry, B. E. Smith has recently placed more ... Oswego Hospital is a 164-bed, Joint Commission-accredited, acute ...
(Date:5/20/2013)... 2013 Irritable Bowel Syndrome, or IBS, ... alteration of bowel habits, and is a difficult condition ... should. The muscles of the colon may overreact to ... to occur subsequent to an infection or a stressful ... flare-ups is gluten, a protein composite found in foods ...
(Date:5/20/2013)... The main objective for the present report ... a single comprehensive report. The objective was to capture ... industry. Thus, it is timely to examine the key ... urgent need in the life science industry for technologies and ... a high-throughput, multiplex and low-cost way. Proteomic technologies are ...
(Date:5/20/2013)... Hampshire (PRWEB) May 20, 2013 ... innovative pain relief products is excited to release ... gemstones for arthritis pain relief. These magnetic health ... beads combined with gemstones. Customers often report pain ... a brief demonstration at shows. , "Having made ...
Breaking Medicine News(10 mins):Health News:Gluten-Free Products Market to Reach $6,206.2 Million by 2018 at a CAGR of 10.2% - New Report by MarketsandMarkets 2Health News:Gluten-Free Products Market to Reach $6,206.2 Million by 2018 at a CAGR of 10.2% - New Report by MarketsandMarkets 3Health News:Oswego Hospital Retains B. E. Smith to Recruit New COO 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Offers improved hCG Diets With More Beneficial Nutritional Content, Possibly Offering Relief for Painful Symptoms of IBS 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Offers improved hCG Diets With More Beneficial Nutritional Content, Possibly Offering Relief for Painful Symptoms of IBS 3Health News:Proteomics Market - Mass Spectrometry & Biochips 2017 Forecast & Analysis in New Research Report at ReportsnReports.com 2Health News:Proteomics Market - Mass Spectrometry & Biochips 2017 Forecast & Analysis in New Research Report at ReportsnReports.com 3Health News:Handmade Magnetic Bracelets with Gemstones Announced by Pain Free Living 2
... treatment of kidney tumors – cryoablation – is as ... research was presented at the Society of Interventional Radiology’s ... trial shows that percutaneous cryoablation results in a slightly ... stay, no major complications, and a 59.5 percent lower ...
... should undergo a month of preventive drug treatment if they ... ,Still, the reviewers say that there’s been little research into ... should be done when health-care workers are exposed to patients ... appears in the current issue of The Cochrane Library, a ...
... largest maker of generic drugs and 19 other companies ... approval. ,The Food and Drug Administration said ... to halt the marketing of unapproved and potentially dangerous ... off the market, agency officials said. The manufacturers could ...
... nitroglycerin in protecting the heart from damage before and ... report today. ,During a heart attack, the ... significant damage to heart muscle and tissue. After the ... the damage and improve their chances of survival. With ...
... of virus transmission from HIV-positive mothers to their children, according ... ,A study in Zambia showed that exclusive breastfeeding ¯ where ... a set time period of four months did not increase ... between US universities and University Teaching Hospital in Lusaka, Zambia. ...
... direct electrical link between nerve cells and photovoltaic ... applying the unique properties of nanoparticles to the ... ,Nanoparticles are artificially created bits of ... same forces that shape molecules control their behavior; ...
Cached Medicine News:Health News:Freezing Kidney Tumors Effective and Less Expensive Than Laparoscopy 2Health News:Health-Care Workers Exposed to HIV on Job Need Preventive Treatment 2Health News:Health-Care Workers Exposed to HIV on Job Need Preventive Treatment 3Health News:FDA Warns Migraine Medicine Makers 2Health News:Erectile Dysfunction Drugs may Trump Nitroglycerin for Heart Protection 2Health News:Breastfeeding Benefits may Outweigh HIV Risk 2Health News:Nanoparticle Research Offers Hope of Artificial Retinas, Prostheses 2
... is designed to remove thrombus in ... jets travel backwards at half the ... low pressure zone causing a vacuum ... catheter where it is fragmented by ...
Redel Connector 10 Pin...
... pulse generators are meeting the clinical ... electrophysiologists and anesthesiologists. And, they are ... expect from Medtronic.,Effective pacing with the ... polarity for quick battery changes. ...
... pacemaker is designed to be used with ... or ventricular or A-V sequential pacing. The ... modes are indicated for therapeutic, prophylactic, or ... be used to measure atrial or ventricular ...
Medicine Products: