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n-3 PUFAs Reduce Mortality and Hospital Admissions in Patients With Symptomatic Heart Failure
Date:9/2/2008

al (GISSI-P) published in The Lancet in 19993, of 11,323 post-myocardial infarction (<3 months previous) patients who received n-3 PUFAs (1 g daily), vitamin E, both, or no treatment (control group), in addition to standard pharmacological treatment and lifestyle advice (approximately 70% of patients were already consuming fish at least once per week). The total mortality was reduced by 20%, with a 45% reduction in sudden death in the n-3 PUFAs group. The GISSI-P trial had shown that 1 g n-3 PUFAs could save 5.7 lives per 1,000 treated patients per year. Interestingly, a sub-analysis from GISSI-P showed that the clinical benefits observed were independent of whether or not patients were also receiving a statin.

Further information about the GISSI-group can be found at http://www.gissi.org/.

*The Protocol is sponsored by Gruppo di Ricerca GISSI and partially supported by: AstraZeneca, Societa Prodotti Antibiotici, Sigma Tau, Pfizer

About heart failure

Heart failure is not a single disease, but instead is the end result of several cardiac disease processes, and is the principle complication of virtually all forms of heart disease. In Europe and the United States altogether, around 10 million people have been diagnosed with chronic heart failure. It places a huge burden on society and despite major advances in drug therapy for symptomatic heart failure, during the past two decades, hospitalisations continue to increase. Therefore, novel and effective treatment is necessary to fulfil unmet needs in the management of heart failure.

About Omacor(R)

This highly purified n-3 polyunsaturated fatty acid (n-3 PUFA) ethyl esters 90, marketed by Solvay under the trade name Omacor(R), is already indicated-as an adjuvant to standard therapies (statins, antiplatelet drugs, beta-blockers and ACE inhibitors)- in Europe and some Middle East countries for secondary prevention of myocardial infar
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SOURCE Solvay Pharmaceuticals
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