Navigation Links
n-3 PUFAs Reduce Mortality and Hospital Admissions in Patients With Symptomatic Heart Failure

MUNICH - ESC Congress 2008, September 2 /PRNewswire-FirstCall/ --

- Presented at the Annual ESC Congress 2008, Munich, Germany, 31 August 2008

For the first time, results from a new landmark trial of purified n-3 polyunsaturated fatty acids (n-3 PUFAs) were presented at one of the worlds' largest cardiology meetings by Professor Luigi Tavazzi (GISSI-HF): n-3 PUFAs reduced mortality and hospital admissions for cardiovascular reasons in patients with symptomatic heart failure(1).

GISSI-HF was a 3.9 year prospective, multicentre, double-blind, placebo-controlled study in 6,975 patients. At a dose of 1 g daily, n-3 PUFAs reduced all-cause mortality by 9% (p=0.041) and the combination of all-cause mortality and admissions to hospital for cardiovascular reasons by 8% (p=0.009), as compared with placebo against a background of optimal recommended therapy (ORT (ACE-inhibitors, beta-blockers, diuretics, digitalis, spironolactone)).


Primary endpoint n-3 PUFAs vs placebo (ORT)

All-cause mortality 9% (p=0.041) *

All-cause mortality or admission to 8% (p=0.009) *

hospital for cardiovascular reasons

Secondary endpoint n-3 PUFAs vs placebo (ORT)

Cardiovascular mortality 10% (p=0.045) *

Cardiovascular mortality or admission to 6% (p=0.043) *

hospital for heart failure or for any


Admission to hospital for cardiovascular 7% (p=0.026) *


Sudden cardiac death 7% (p=0.333)

Admission to hospital for any reason 6% (p=0.049)

Admission to hospital for congestive 6% (p=0.147)

heart failure

Myocardial infarction 18% (p=0.121)

Stroke -16% (0.27

SOURCE Solvay Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Prasugrel Head-to-Head Study Showed Reduced Cardiovascular Events in Diabetes Patients by 30 Percent Compared with Clopidogrel
2. National Study Shows Magnesium Sulfate Reduces Risk of Cerebral Palsy in Premature Births
3. Bad News to Bad Bugs: Northern Antibiotics Develops Novel Polymyxins With Reduced Toxicity
4. DaVita Strives to Improve Quality of Life and Reduce Overall Costs of Kidney Care Through Community-Based Education
5. New Study: Pine Bark Significantly Reduces Menstrual Pain
6. ACTEMRA(R) (tocilizumab) Significantly Reduces Rheumatoid Arthritis Signs and Symptoms Regardless of Previous Therapy in Two New Global Studies
7. Patients Taking Cymbalta(R) Reported Reduced Pain Severity of Osteoarthritis of the Knee in New Study
8. Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
9. The Largest Ever Study of Diabetes Shows Intensive Glucose Control Reduces Serious Complications
10. CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI
11. Data Show Rufinamide, an Investigational Adjunctive Treatment for Lennox- Gastaut Syndrome, Reduced Drop Attacks by More Than 40%
Post Your Comments:
(Date:10/30/2014)... , Oct. 30, 2014  CytRx Corporation (NASDAQ: ... development company specializing in oncology, today announced an ... lead drug candidate, aldoxorubicin.  The presentation, titled, "Drug ... will be given by Sant P. Chawla ... Center and principal investigator of the Company,s ongoing ...
(Date:10/30/2014)... -- , La fórmula de leche ... tolerancia a la proteína de leche de vaca  ... leche de la vaca (APLV) es la principal alergia alimentaria ... APLV se trataba eliminando las proteínas lácteas de ... posible adquirir tolerancia oral en un número significativo ...
(Date:10/30/2014)... Oct. 30, 2014  TWi Pharmaceuticals, Inc. today announced ... States Food and Drug Administration (FDA) on its Abbreviated ... 23 mg, the generic equivalent to Eisai Inc.,s Aricept® ... patients. TWi Pharmaceuticals is preparing to launch ... subsidiary, TWi Pharmaceuticals USA , at ...
Breaking Medicine Technology:CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 2CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 3CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 4Según expertos reunidos en el Simposio Allergy Day 2Según expertos reunidos en el Simposio Allergy Day 3
... 28, 2011 Nile Therapeutics, Inc. (Nasdaq: ... novel therapeutics for heart failure patients, today announced plans ... ) on the clinical development of Nile,s proprietary natriuretic ... disease applications. "We are very pleased to ...
... Feb. 28, 2011 PAREXEL International Corporation (Nasdaq: ... presenting at the Raymond James Investors Conference in Orlando, FL. ... be making a presentation on PAREXEL at 2:50 p.m.  ET ... of this presentation will be available through the "Investors" ...
Cached Medicine Technology:Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 2Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 3PAREXEL International to Present at Raymond James Investors Conference 2
(Date:10/28/2014)... "Epithelial cell layers line all of the inner and ... for example in the lung, intestine, pancreas and in ... hair-like, microtubule-based structures – project from BBs and are ... through this exact positioning can cilia movements be coordinated ... from the lung or sound can be perceived from ...
(Date:10/28/2014)... hormonal therapy is known to substantially reduce breast ... about one-half of patients fail to take their ... Medical Center (CUMC) researchers has found that the ... type of hormone therapy), which are considerably less ... by 50 percent. , The study was published ...
(Date:10/28/2014)... study, researchers from Uppsala University demonstrate that elderly ... risk of developing Alzheimer,s disease than men without ... the scientific journal Alzheimer,s & Dementia . ... who were initially 50 year old, between the ... study show that self-reported sleep disturbances were linked ...
(Date:10/27/2014)... price tag for informal caregiving of elderly people by ... $522 billion a year, according to a new RAND ... care at minimum wage would cost $221 billion, while ... $642 billion annually. , The study, published online ... estimates about the value of informal caregiving by making ...
(Date:10/27/2014)... Do blood vessels that feed tumors differ from other blood ... led to the discovery of several genes that are more ... New research now reveals the normal function of one of ... for anticancer drug therapy. , A summary of the research ... 27. , The mystery of the gene, TEM5, began in ...
Breaking Medicine News(10 mins):Health News:New insights into the development of ciliopathies 2Health News:Generic medications boost adherence to breast cancer therapy 2Health News:Generic medications boost adherence to breast cancer therapy 3Health News:Cost of informal caregiving for US elderly is $522 billion annually, study finds 2Health News:Blood vessel growth in the brain relies on a protein found in tumor blood vessels 2
... life hangs between life and death, suffering an extremely rare ... transplant, which will give him a new lease of life. ... will be donating a kidney each. , ,Mrs ... felt so helpless, especially as you're used to doing everything ...
... confirmed that the bird flu virus found in poultry in ... to humans as well //. ,As chief veterinarian ... laboratory that it was the highly pathogenic H5N1 strain of ... ,This is the first report of the H5N1 virus in ...
... Hospital's two pediatricians, Jo McCubbin and Peter Goss have ... months notice //. However a full time replacement ... ,This has led to concerns among obstetricians at ... obstetricians would not be able to deliver premature babies ...
... of laws was initiated by Quebec Health Minister Philippe Couillard ... health-care insurance //. ,The Supreme Court of Canada ... on June 9, 2005,ruling that Quebec had failed to prove ... medicare, was justified. However with the development of Bill ...
... Ramadoss Friday warned of "strong action" against "indiscipline" he ... of Medical Sciences// (AIIMS), saying a coterie had turned ... people have converted the AIIMS into a political hub ... return to New Delhi June 19," Ramadoss told reporters ...
... the Karolinska Institutet they have found ways to control the ... intestinal stem cell. The result of the study was published ... help in the development of new drugs for diseases such ... body, old cells are continually being replaced by new. If ...
Cached Medicine News:Health News:Quebecers To Choose Private Health-Care Insurance 2Health News:Mechanism of Stem Cell Regulation Identified 2
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
... II Hybrid External Fixation System incorporating ... in hybrid fixation. It incorporates features ... is designed to offer speed of ... Hoffmann® snap-fit technology. , ,Using the ...
Versatility of the DFS Standard Fixator provides unsurpassed below-the-ring correction of angular, rotational and translational deformities. Length discrepancy can be precisely corrected in 1/4mm inc...
Medicine Products: