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Metabolic Solutions Development Company Receives $1.1 Million NIH Grant to Further Investigate MSDC-0602 for the Treatment of Fatty Liver Disease
Date:10/6/2011

KALAMAZOO, Mich., Oct. 6, 2011 /PRNewswire/ -- Metabolic Solutions Development Company, LLC (MSDC) announced today it has received a $1.1 million multi-year Small Business Technology Transfer Program (STTR) grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) of the National Institutes of Health (NIH). MSDC will use this new funding to further evaluate MSDC-0602 in animal models of fatty liver disease (FLD). FLD occurs worldwide and refers to a group of conditions which lead to an accumulation of excess fat in the liver of people who consume excessive alcohol or who are obese(1).

MSDC-0602 is a novel insulin sensitizer that is selective for a molecular target, mTOT, which functions as a "switch" connecting mitochondrial metabolism to important cell functions. In a recently completed Phase 2a study in patients diagnosed with type 2 diabetes, MSDC-0602 was shown to achieve significant glucose control and increase insulin sensitivity in a PPAR-independent manner.

"Our unique understanding of the mTOT biochemical pathway will enable MSDC's researchers, working in collaboration with our colleagues at the Washington University School of Medicine, to select compounds that treat the root cause of some of the most pressing health issues facing Americans today," said Stephen Benoit, chief executive officer, MSDC. "Importantly for patients diagnosed with fatty liver disease, these new therapeutics won't have the unwanted side effects associated with currently available insulin sensitizers."

Studies conducted under this grant will be led by principal investigators, Rolf Kletzien, PhD, senior vice president of research at MSDC, and Brian Finck, PhD, assistant professor in medicine, Washington University School of Medicine, Division of Geriatrics and Nutritional Science.

In previous preclinical studies funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the PPAR-independent pharmacology of MSD
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SOURCE Metabolic Solutions Development Company, LLC
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