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Initial Trial of Sanaria's Malaria Vaccine Yields Positive Results
Date:9/8/2011

rozoite vaccine administered by needle and syringe," says Stephen L. Hoffman, MD, Sanaria's Chief Executive and Scientific Officer.  

Sanaria has developed a unique manufacturing process that meets FDA standards to produce the Sanaria® PfSPZ Vaccine. The vaccine is composed of attenuated (weakened) malaria sporozoites that are the stage transmitted to humans by mosquitoes.

The vaccine was tested by a team of biomedical scientists from the U.S. Military Malaria Vaccine Program (Naval Medical Research Center and Walter Reed Army Institute of Research); University of Maryland Center for Vaccine Development; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Sanaria Inc.; PATH Malaria Vaccine Initiative; and Protein Potential, LLC. The principal findings and conclusions reported in Science are:

  1. Sanaria® PfSPZ Vaccine was safe and well tolerated in this Phase 1 clinical trial in humans.
  2. Sanaria® PfSPZ Vaccine administered in the skin by needle and syringe to humans was immunogenic and protective, but not nearly to the levels found after mosquito bite immunization.
  3. Sanaria® PfSPZ Vaccine administered by intravenous injection to animals, triggered unprecedented high levels of malaria parasite-specific CD8+ T cells in the liver, the hallmark of protective immunity.
  4. Sanaria® PfSPZ Vaccine is highly potent.

Based on these results, the PfSPZ Vaccine administered by intravenous injection will soon be assessed in a clinical trial at the Vaccine Research Center, NIAID, NIH in the United States. A trial in Tanzania is also being planned.  

Professor Marcel Tanner, Director Swiss Tropical and Public Health Institute, comments, "Sanaria has ushered in a whole new era of malaria vaccine development and testing. We are heartened that a path toward a vaccine that can be used
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SOURCE Sanaria Inc.
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