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iBio And Caliber Biotherapeutics Establish License And Collaboration Relationship
Date:2/19/2013

s otherwise derived from blood plasma; and replacement enzymes used to treat a variety of orphan diseases.  The technology has demonstrated capabilities to express proteins that were not commercially feasible to produce using other systems, and unlike technologies dependent on transgenic cells and organisms, utilizes advanced informatics and new synthetic biology techniques for superior clinical product design and delivery.  Human clinical trials of product candidates produced with iBio's technology have been funded by the U.S. Department of Defense and the Bill & Melinda Gates Foundation.

Caliber's current facility capacity for therapeutic protein at typical yields is over 300 kilograms of active pharmaceutical ingredient per year (which would yield around one billion doses of a typical subunit vaccine product or 300,000 doses of a typical antibody product), which can be quickly expanded based on demand.  The facility design enables concurrent development and production of multiple products and rapid changeover.  The Caliber facility together with the iBioLaunch™ technology also enables extraordinary surge capacity for vaccines and biotherapeutics against pandemic disease and bioterrorism. 

Under the terms of the agreement, iBio will receive license and milestone fees for development of product targets selected by Caliber.  Caliber will be responsible for funding clinical development and commercialization of such collaboration products, and iBio will receive royalties on product sales and other revenues.  Detailed financial terms of the agreement have not been disclosed.

"This combination is a major advance for recombinant biopharmaceuticals," said Robert B. Kay , Executive Chairman and CEO of iBio.  "By bringing together our intellectual property, facilities, and know-how, we not only will accelerate and improve development of our own product pipelines, but also e
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SOURCE iBio, Inc.
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