Navigation Links
iBio And Caliber Biotherapeutics Establish License And Collaboration Relationship
Date:2/19/2013

NEWARK, Del. and BRYAN, Texas, Feb. 19, 2013 /PRNewswire/ -- iBio, Inc. (NYSE MKT: IBIO), and Caliber Biotherapeutics LLC (Caliber) today announced execution of a License and Collaboration Agreement for development and production of recombinant plant-based biopharmaceuticals using iBio's proprietary iBioLaunch™ technology and Caliber's unique and proprietary plant-based manufacturing capabilities.

(Logo: http://photos.prnewswire.com/prnh/20120419/NY91086LOGO)
(Logo: http://photos.prnewswire.com/prnh/20130219/NY61582LOGO)

The new relationship establishes a turn-key plant-based biopharmaceutical development capability, from the earliest stage of product selection and optimization through large-scale production.  iBio and Caliber will use their combined capabilities for their own product portfolios, starting with an undisclosed monoclonal antibody for oncology indications, where Caliber and its affiliates have demonstrated expertise.  The Companies also will make their combined capabilities available to third parties through licensing and partnering arrangements for other recombinant plant-based biotherapeutics and vaccines.

iBio's patented iBioLaunch™ technology, developed over nine years at a cost of more than US$100 million, causes common green plants to produce commercial quantities of targeted human proteins in proper form for use as the active pharmaceutical ingredients for the development and production of biopharmaceuticals.  Caliber owns and operates the world's largest-capacity cGMP commercial manufacturing facility for plant-made biopharmaceutical products.

iBio's technology platform is broadly applicable to recombinant vaccines and biotherapeutic products, including:  monoclonal antibodies; proteins otherwise derived from blood plasma; and replacement enzymes used to treat a variety of orphan diseases.  The technology has demonstrated capabilities to express proteins that were not commercially feasible to produce using other systems, and unlike technologies dependent on transgenic cells and organisms, utilizes advanced informatics and new synthetic biology techniques for superior clinical product design and delivery.  Human clinical trials of product candidates produced with iBio's technology have been funded by the U.S. Department of Defense and the Bill & Melinda Gates Foundation.

Caliber's current facility capacity for therapeutic protein at typical yields is over 300 kilograms of active pharmaceutical ingredient per year (which would yield around one billion doses of a typical subunit vaccine product or 300,000 doses of a typical antibody product), which can be quickly expanded based on demand.  The facility design enables concurrent development and production of multiple products and rapid changeover.  The Caliber facility together with the iBioLaunch™ technology also enables extraordinary surge capacity for vaccines and biotherapeutics against pandemic disease and bioterrorism. 

Under the terms of the agreement, iBio will receive license and milestone fees for development of product targets selected by Caliber.  Caliber will be responsible for funding clinical development and commercialization of such collaboration products, and iBio will receive royalties on product sales and other revenues.  Detailed financial terms of the agreement have not been disclosed.

"This combination is a major advance for recombinant biopharmaceuticals," said Robert B. Kay , Executive Chairman and CEO of iBio.  "By bringing together our intellectual property, facilities, and know-how, we not only will accelerate and improve development of our own product pipelines, but also enable third-party developers and sponsors to access turn-key solutions for their product candidates through licenses and partnerships with us."

Dr. Rahul Singhvi , Managing Director of Caliber Biotherapeutics, stated:  "This new collaboration with iBio enables us to develop products addressing important unmet medical needs that uniquely benefit from Nicotiana benthamiana plant-based expression technology.  The combination of iBio's state-of-the-art expression technology and Caliber's innovative manufacturing infrastructure makes the promise of plant-based pharmaceuticals very real.  We are excited about combining our joint capabilities to create valuable products that would otherwise be commercially impossible to produce or develop."

About iBio, Inc.

iBio develops and offers product applications of its iBioLaunch™ and iBioModulator™ platforms, providing collaborators full support for turn-key implementation of its technology for both proprietary and biosimilar products. The iBioLaunch platform is a proprietary, transformative technology for development and production of biologics using transient gene expression in unmodified green plants. Advantages over other systems include: success with proteins difficult or impossible to produce with other methods; broadly applicable to biologics, including therapeutic proteins and vaccines; production time measured in weeks instead of months or more. Additional benefits include a practically unlimited surge capacity for remedial action against bioterrorism and pandemic disease; product entry that is unconstrained by traditional process patents, and significantly lower capital and operating costs for comparable production. The iBioModulator platform is complementary to the iBioLaunch platform and enables significantly improved vaccine products with higher potency and greater duration of effect. The iBioModulator platform can be used with any recombinant expression technology for vaccine development and production. Further information is available at: www.ibioinc.com.

About Caliber Biotherapeutics, LLC

Caliber Biotherapeutics, LLC is a biotechnology company based in Bryan, Texas with a mission to develop and commercialize protein-based therapeutics that improve outcomes for patients with cancer and other diseases.  The Company utilizes technological innovations in biological research, product development and manufacturing to create treatments with increased safety and effectiveness--while reducing both costs and development time.  Caliber has created a rich pipeline of monoclonal antibody-based products, including biobetter product candidates applying its expertise in the Nicotiana benthamiana plant-based expression and manufacturing of recombinant proteins.  Caliber operates the world's largest N. benthamiana expression based protein manufacturing facility, in Bryan, Texas.  For more information, please visit www.caliberbio.com.

Forward-Looking Statements 

Statements included in this news release related to iBio, Inc. may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements involve a number of risks and uncertainties such as competitive factors, technological development, market demand, and the Company's ability to obtain new contracts and accurately estimate net revenues due to variability in size, scope and duration of projects. Further information on potential risk factors that could affect the Company's financial results can be found in the company's reports filed with the Securities and Exchange Commission.

Caliber Safe Harbor:

This release contains forward-looking statements that are not based on historical fact.  These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements.  Readers are cautioned not to place undue reliance on such forward-looking statements. 

Contacts

iBio, Inc.
Corporate:
Robert Erwin , President
302-355-2335
rerwin@ibioinc.com

Caliber Biotherapeutics, LLC
Rahul Singhvi , Managing Director
240-308-0225
rsinghvi@caliberbio.com


'/>"/>
SOURCE iBio, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Lucid, Inc. Reflects New Vision with Name Change to Caliber Imaging & Diagnostics, Inc.
2. Caliber Imaging & Diagnostics Releases New Products for Noninvasive, Rapid Imaging of Living Cells
3. Caliber IDs VivaScope technology found to be 100% sensitive for basal cell carcinoma diagnosis
4. Caliber and ImmunGene Launch Valor Biotherapeutics, a Joint Venture to Develop Antibody-Interferon Fusion Therapeutics to Treat Cancers
5. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
6. Actinium Pharmaceuticals Inc. Pays Regulatory Milestone to Abbott Biotherapeutics Corp.
7. Healthpoint Biotherapeutics Initiates Phase III Study of Unique Investigational Cell-Based Therapy for Venous Leg Ulcers
8. Northwest Biotherapeutics Announces Public Offering of Common Stock and Warrants, and Listing on NASDAQ
9. Northwest Biotherapeutics, Inc. Announces Full Exercise of Over- Allotment Option
10. Quest Diagnostics Establishes Unique Healthcare Identifier to Improve Access to Vital Patient Health Information; 80 Million Patient IDs Created to Date
11. BIOCRATES Life Sciences to Launch Waters Xevo® TQ MS Editions for Two of its Well-established Research Kit Products, AbsoluteIDQ® p180 and p150
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... , March 24, 2017  GenomeDx Biosciences today announced ... Database) and Decipher® Prostate Cancer Classifier tests will be ... of Urology (EAU) Congress held March 24 to 28, ... Annual EAU Congress is Europe,s ... research in the urological field. The abstract ...
(Date:3/24/2017)... GENEVA , March 24, 2017 /PRNewswire/ ... Day revitalizes efforts to develop sutezolid as effective response ... Tuberculosis Day, TB Alliance and the Medicines Patent Pool ... of sutezolid, an antibiotic drug candidate which demonstrated encouraging ... development of sutezolid in combination with other TB drugs ...
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Procedure By Technique, Repair Procedure By Technique, By Region, By Country ... ... to grow at a CAGR of 13.35% during 2016-2021 ... aging population, growth in population with heart disease and rising advances ...
Breaking Medicine Technology:
(Date:3/25/2017)... ... ... Getting earned media coverage meaningful for Garden Media Group's clients is the ... Garden Media aims to provide material helpful to clients’ goals and bottom lines. By ... messages to gain coveted media placements, Garden Media wows clients year-round. , Here ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... countries to hospitals in the United States, it’s a threat that is constantly ... obstacles facing infection prevention and offers strategies for the healthcare community to help ...
(Date:3/24/2017)... ... March 24, 2017 , ... The iaedp Foundation, the premier provider of ... for those suffering from the full spectrum of disordered eating, announced today that the ... from nearly all 50 states and several countries converged on the Green Valley Resort ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... announce that they are now offering treatments for sleep apnea and TMJ at ... offices. Sleep apnea , specifically the obstructive type, is increasingly being treated ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... the year of enhancements, upgrading their training and leads programs. , In February, ... Reserved for elite sales agents, Performance Partners is designed to teach how to ...
Breaking Medicine News(10 mins):