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GPCRs in Drug Discovery - Efforts to De-Orphanize Novel GPCR Targets are Increasing
Date:10/25/2011

Compugen, Ltd. 123

8.1.14 Tranzyme Pharma, Inc. 124

8.1.15 Oxagen Limited 125

8.1.16 Prosarix Ltd. 125

8.1.17 Acadia Pharmaceuticals Inc. 126

8.1.18 Actelion Ltd. 127

8.1.19 AcurePharma AB 127

8.1.20 DiscoveRx 127

8.2 GPCRs in Drug Discovery – Top 5 Companies as per Number of Molecules in NDA Filed and in Phase III 128

8.2.1 Merck & Co., Inc. 128

8.2.2 Novartis AG 130

8.2.3 Pfizer Inc. 131

8.2.4 Eli Lilly and Company 132

8.2.5 Johnson and Johnson 133

9 GPCRs in Drug Discovery – Strategic Consolidations 134

9.1 AstraZeneca Enters Into Co-Development Agreement With Heptares 134

9.2 Heptares Therapeutics Enters Into Option Licensing Agreement With Shire For Adenosine A2A 134

9.3 Dimerix Bioscience Enters Into Research Agreement With Takeda Cambridge 135

9.4 Heptares Therapeutics Enters Into Drug Discovery Collaboration With Takeda Pharmaceutical Company Ltd. 135

9.5 ACADIA Pharmaceuticals Extends Drug Discovery Collaboration With Allergan 136

9.6 Omeros Expands Licensing Agreement With Daiichi Sankyo 136

9.7 Domain Therapeutics Enters Into Licensing Agreement With Merck Serono 137

9.8 Receptos Enters Into Collaboration with Eli Lilly 137

9.9 Receptos Enters Into Licensing Agreement With Ortho-McNeil-Janssen Pharmaceuticals 138

9.10 Anchor Therapeutics Enters Into Licensing Agreement with Ortho-McNeil-Janssen 138

10 GPCRs in Drug Discovery – Appendix 139

10.1 Market Definitions 139

10.2 Abbreviations 139

10.3 Research Methodology 139

10.3.1 Coverage 139

10.3.2 Secondary Research 140

10.3.3 Primary Research 140

10.3.4 Expert Panel Validation 140

10.3.5 Section-wise Methodology 141

10.4 Contact Us 143

10.5 Disclaimer 143

10.6 Sources 143

1.1 List of Tables

Table 1: GPCRs in Drug Dis
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