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diaDexus, Inc. Highlights Findings from Two Outcomes Studies for its PLAC Lp-PLA(2) Activity Assay
Date:3/19/2012

inflammatory marker. The individuals enrolled in these studies had markedly different cholesterol levels. LIPID patients had high LDL cholesterol levels between 155 to 217 mg/dL while the JUPITER patients had lower LDL cholesterol levels of 130 mg/dL or less at time of enrollment.

…LIPID Trial – Conclusions*

  • Reduction in Lp-PLA(2) is a significant predictor of coronary heart disease events.
  • Change in Lp-PLA(2) may account for a substantial proportion of pravastatin (Pravachol®) effect in reducing coronary heart events.
  • Higher baseline levels of Lp-PLA(2) activity significantly predict an increased risk of cardiovascular events including coronary heart disease death and myocardial infarction, similar total cardiovascular events and all-cause mortality – but not in multivariate analysis, except for coronary heart disease death.
  • Similar relative effects of pravastatin were observed within each subgroup defined by baseline Lp-PLA(2) quartiles (and with greater absolute benefit among those with higher baseline levels).

* DH White et.al., Circulation 124:A14857 (2011)

…JUPITER Trial – Conclusions**

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