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Decision Resources' Forecast of Global Tanezumab Sales Slashed Following FDA Halt of Phase III Studies
Date:10/26/2010

BURLINGTON, Mass., Oct. 26 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that because Phase III trials of Pfizer's tanezumab for the treatment of osteoarthritis pain were halted over U.S. Food & Drug Administration safety concerns, Decision Resources' Pharmaview 2016 global sales forecast for tanezumab has been reduced by $1.2 billion to $200 million. The decision to end the trial was made after a subset of patients in the trial required joint replacement surgery due to worsened conditions.

The discontinuation of the trial is a setback for the drug and a concern for the entire drug class, as tanezumab was the most clinically advanced agent of a family of anti-nerve growth factor (NGF) monoclonal antibodies (MAbs). Anti-NGF MAbs have garnered considerable attention from large pharmaceutical companies for the novel mechanism of action; Sanofi-Aventis (SAR164877), Johnson & Johnson (AMG-403) and Abbott (PG-110) are each in an early-stage program.

"With Lipitor, Celebrex and Viagra all facing patent expiries over the next several years, Pfizer greatly needs new agents to fill the revenue gap," said Pharmaview Analyst Michael Latwis, M.B.A. "Unfortunately, given that approval for osteoarthritis pain—the largest potential market for tanezumab—is highly unlikely, our Pharmaview model does not expect sales to reach anywhere near blockbuster status."

New Pharmaview Platform ReleasedDecision Resources has released a new delivery platform for its Pharmaview product. Pharmaview provides continually updated analysis on more than 2,100 drugs from more than 250 companies, covering 150 product classes and 14 therapy areas—complete with more than 1,200 product-level forecasts.

The new platform includes not only expanded coverage of the biopharmaceutical industry, but enhanced functionality including improved search capabilities an
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SOURCE Decision Resources
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