Navigation Links
deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia
Date:7/30/2008

agnosis and intervention. These discoveries also demonstrate one way in which we can use SNP-chips to find rarer genetic factors conferring risk of disease. In many disease areas we have had great success of late in identifying what these chips are best suited to find: common variants conferring relatively modest increases in risk. But we know that individuals with certain mental disorders such as schizophrenia tend to have few children, and thus that we may have to identify a larger number of rare but high risk variants to understand the genetic contribution to susceptibility. It is encouraging that our efforts to use SNP chips to detect rarer variations such as spontaneous deletions and duplications is now bearing fruit," said Kari Stefansson, CEO of deCODE.

In the recent wave of discoveries of risk variants for common diseases, those associated with mental disorders such as schizophrenia, autism and others have been conspicuously absent. This phenomenon, and the fact that people with these disorders tend to have few children, suggest that rarer and perhaps spontaneously generated variants may account for a greater proportion of the disease burden in these conditions than in others. SNP-chips are not well suited to finding rare SNPs but can, with sufficiently large sample sizes, be used to identify deletions and duplications -- known as copy number variations, or CNVs -- which can also be carried by healthy individuals in one generation and contribute to risk of disease in the next.

In order to identify novel CNVs, deCODE first analyzed the genomes of a total of approximately 15,000 parents and offspring taking part in deCODE gene discovery programs and who had been genotyped with the more than 300,000 SNPs on the HumanHap300 chip. The deCODE team discovered 66 de novo CNVs, that is, CNVs present in the genomic DNA of the offspring but not in that of their parents. deCODE then tested these variants for association with schizophrenia in more than 1,40
'/>"/>

SOURCE deCODE genetics
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. deCODE Launches Phase II Clinical Testing of DG051 for the Prevention of Heart Attack
2. deCODE Launches deCODE MI(TM) -- A Test for a Major Genetic Risk Factor for Early-onset Heart Attack
3. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
4. deCODE Obesity Study Sheds Light on How Genetics Affects Risk and Onset of Common Diseases
5. deCODE Discovers Novel Genetic Links Between Pigmentation Traits and Risk of Skin Cancer
6. Marketing of Diagnostics and deCODEme(TM), Recent Progress in Drug Development to be Highlighted at deCODE R&D Event
7. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
8. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
9. Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
10. Childrens Brain Tumor Foundations Tissue Bank Consortium May Solve Dire Problem in Pediatric Cancer Research
11. National Stem Cell Holding, Inc. Discovers Non-Embryonic Biomaterials that Promote Tissue Repair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... Dec. 16 Siemens Healthcare ... solutions to help ... meet deadlines defined within the HITECH provision ... (ARRA). Featuring zero-percent interest terms ... to defer up-front payments associated with their ...
(Date:12/16/2009)... -- Biovista Inc.,today announced that it was awarded ... the 2009 New England Venture Summit, held on ... cutting edge private companies,driving the future of innovation, ... other privately held companies that play a leading ... Clean-tech sectors. , "We ...
(Date:12/16/2009)... Today, Avantium announced the,appointment of Gunnar Staaf ... Gunnar Staaf previously worked at Serentis Ltd, ... in a range of commercial and executive,positions. ... Avantium,s plan to,spin-out its pharmaceutical business. The ... based on its offering of proprietary,crystallization services ...
Breaking Medicine Technology:Siemens Unveils Flexible Financing Solutions to Help Providers Achieve Meaningful Use 2Siemens Unveils Flexible Financing Solutions to Help Providers Achieve Meaningful Use 3Siemens Unveils Flexible Financing Solutions to Help Providers Achieve Meaningful Use 4Biovista Inc. Named Top Innovator in Life Sciences 2Avantium Appoints Gunnar Staaf as CEO Pharma 2Jeremy M Stipkala to Lead Symposium Entitled Patent Law Developments at SERMACS 2009 14458 1Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 1Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 2Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 3Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 4Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 5Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 6Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 7Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 8Escalon 28R 29 Reports Fourth Quarter and Fiscal 2009 Results 5450 9Statement of Robert Greenstein Executive Director Center on Budget and Policy Priorities on The Senate Finance Committees Health Reform Plan 59410 1Statement of Robert Greenstein Executive Director Center on Budget and Policy Priorities on The Senate Finance Committees Health Reform Plan 59410 2Statement of Robert Greenstein Executive Director Center on Budget and Policy Priorities on The Senate Finance Committees Health Reform Plan 59410 3
(Date:12/16/2009)... acids commonly found in fatty fish and algae ... published by the American Psychological Association. The finding ... in people with schizophrenia; bipolar, obsessive-compulsive, and attention-deficit ... the nervous system. , The study, reported ... more evidence that fish is brain food. The ...
(Date:12/16/2009)... time in half, but use in humans is still far ... improve on nature, researchers have built and tested synthetic versions ... trauma or other cases where blood just won,t stop flowing. ... is used in degradable stitches, which dissolve in the body," ... Case Western Reserve University, and lead author of a report ...
(Date:12/16/2009)... Therapy or NSRTSM is found very effective in the alleviation ... asthma, migraines, chronic fatigue and a wide array of skin ... using this holistic therapy including over 50 branded BioVeda Health ... ... MN (Vocus) December 14, 2009 -- BioVeda Health and Wellness ...
(Date:12/16/2009)... percent of children are uninsured, government report finds , , ... six months of this year, 45.4 million Americans of ... -- had no health insurance, according to new National ... 58.4 million (19.4 percent) people of all ages had ... prior to the interview, and 31.9 million (10.6 percent) ...
(Date:12/16/2009)... -- OrthoAccel Technologies, Inc., developers of the ... to enhance orthodontics, announced Alison Davies as its ... Ms. Davies has spent the last fourteen years ... most recently for nine years as a senior ... Invisalign . ,, (Logo: ...
Breaking Medicine News(10 mins):Health News:New study links DHA type of omega-3 to better nervous-system function 2Health News:Synthetic Platelets Put the Brakes on Blood Loss 2Health News:Synthetic Platelets Put the Brakes on Blood Loss 3Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 2Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 3Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 4Health News:BioVeda Health and Wellness Center of Chanhassen, MN Announces Its Grand Opening 5Health News:Over 45 Million Americans Now Lack Health Insurance 2Health News:Top-performing Sales Manager Joins OrthoAccel Technologies, Inc. in the United Kingdom 2Health News:Top-performing Sales Manager Joins OrthoAccel Technologies, Inc. in the United Kingdom 3Health News:Top-performing Sales Manager Joins OrthoAccel Technologies, Inc. in the United Kingdom 4
... ReBuilder,Medical Technologies, Inc. (Pink Sheets: RBRM), an ... device inventor David B.,Phillips, Ph.D., today announced ... facilitation. (Logo: http://www.newscom.com/cgi-bin/prnh/20061128/REBUILDERLOGO ) ... are outsourcing customer service to,overseas facilities, the ...
... a common,problem, yet the antibiotics physicians prescribe to ... this condition work in only a fraction of,cases. ... a form called,chronic nonbacterial prostatitis, which is particularly ... Harvard Medical School,s Perspectives on Prostate,Disease describes, urologists ...
... Device is the World,s First Accurate Non-Contact Clinical ... Kidz-Med, Inc., a division of,American Scientific Resources, (ASFX-OTC) ... thermometer, the first non-contact clinical,thermometer in the world, ... revolutionary Thermofocus 5-in-1, made in Italy and long,recommended ...
... at the Hebrew University of Jerusalem have developed a ... holds out promise of providing improved movements of natural ... or paralyzed. , Neuroscientists have long been working ... brain activity and behavior, and especially between neural activity ...
... Davis School of Gerontology found that caregivers of different ... as a result of tending to a family member ... in the September 2007 journal Aging & Mental Health, ... and white caregivers. , A population-based sample of ...
... Under 5 in Madagascar to Sleep Under Bed Nets, ... and,Sumitomo Chemical have teamed up to contribute to the ... between October 22-29. Led by the Malagasy government, ... months to five years old receives a bed net. ...
Other Medicine News:Health News:ReBuilder Medical Technologies, Inc. Hires Nurses Exclusively to Provide Customer Support 2Health News:ReBuilder Medical Technologies, Inc. Hires Nurses Exclusively to Provide Customer Support 3Health News:Antibiotics May Not Help Men's Chronic Pelvic Pain: Harvard Doctors Discuss Alternatives 2Health News:Kidz-Med to Launch the Thermofocus(R) 5-in-1 Exclusively at Walgreens Stores Nationwide 2Health News:Kidz-Med to Launch the Thermofocus(R) 5-in-1 Exclusively at Walgreens Stores Nationwide 3Health News:Brain measurements could lead to better devices to move injured or artificial limbs 2Health News:Brain measurements could lead to better devices to move injured or artificial limbs 3Health News:USC study examines effects of caregiving 2Health News:Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria 2Health News:Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria 3
Functional trainer...
... Pore Gradient Lipoprotein Electrophoresis System (PGGE) ... such as low density lipoproteins (LDL) ... on particle size using nondenaturing pore ... standard PAGE and short DNA sequencing ...
... System separates HDL into large, intermediate and ... each subfraction. The test procedure is simple ... three hours. A color coded profile is ... seen., ,The Lipoprint HDL Kit contains all ...
... a high resolution diagnostic test for cholesterol components ... The test procedure is simple and can be ... value is clearly flagged. A color coded profile ... LDL in red and the good HDL in ...
Medicine Products: